2011
DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma
Liu H, Dong H, Robertson K, Liu C. DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma. American Journal Of Pathology 2011, 178: 652-661. PMID: 21281797, PMCID: PMC3069978, DOI: 10.1016/j.ajpath.2010.10.023.Peer-Reviewed Original ResearchMeSH KeywordsCarbamoyl-Phosphate Synthase (Ammonia)Carcinoma, HepatocellularCell Line, TumorCpG IslandsDNA MethylationGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 3-betaHepatocytesHumansLiver NeoplasmsPromoter Regions, GeneticQuaternary Ammonium CompoundsRNA, MessengerUreaConceptsHCC cellsNoncancerous tissuesTumor tissueHepatocyte paraffin 1 antibodySurgical pathology practiceLiver cancer tissuesHuman HCC cellsCPS1 expressionHCC tumor tissuesLiver tumor tissuesHuman hepatocellular carcinomaHuman hepatocellular carcinoma cellsCultured human primary hepatocytesHuman primary hepatocytesHepatocellular carcinoma cellsHepatocellular carcinomaCPS1 geneRate-limiting enzymeLiver carcinogenesisCancer tissuesSynthetase 1Potential biomarkersCarbamoyl phosphate synthetase 1Pathology practiceCarcinoma cells
2009
Loss of Carbamoyl Phosphate Synthetase I in Small-Intestinal Adenocarcinoma
Cardona D, Zhang X, Liu C. Loss of Carbamoyl Phosphate Synthetase I in Small-Intestinal Adenocarcinoma. American Journal Of Clinical Pathology 2009, 132: 877-882. PMID: 19926579, DOI: 10.1309/ajcp74xgrfwtflju.Peer-Reviewed Original ResearchConceptsCases of duodenitisWestern blot analysisHep Par 1 antibodyHep Par 1 expressionHep Par 1Low-grade dysplasiaPAR-1 expressionBlot analysisExpression of CPS1CPS1 expressionIntestinal adenocarcinomaImmunohistochemical findingsInvasive adenocarcinomaInvasive tumorsMalignant tumorsAntigen expressionNormal mucosaControl groupAdenocarcinomaPAR-1AdenomasSmall intestine enterocytes
2007
The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1
Butler S, Dong H, Cardona D, Jia M, Zheng R, Zhu H, Crawford J, Liu C. The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1. Laboratory Investigation 2007, 88: 78-88. PMID: 18026163, DOI: 10.1038/labinvest.3700699.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigensBase SequenceBlotting, WesternCarbamoyl-Phosphate Synthase (Ammonia)Chromatography, LiquidDNA PrimersFemaleHumansImmunoprecipitationLiver NeoplasmsMaleReverse Transcriptase Polymerase Chain ReactionSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryConceptsHep Par 1 antibodyHep Par 1Carbamoyl phosphate synthetase 1Carcinoma cell linesHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePAR-1Cell linesHepatocyte paraffin 1Small intestinal tissueSurgical pathology practiceCPS1 expressionMurine monoclonal antibodiesHepatoid tumorsHuman liver tissueHepatocellular originIntestinal tissueRate-limiting enzymeLiver carcinogenesisSynthetase 1Liver tissuePathology practiceAntigenLiver pathobiologyMonoclonal antibodies