2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchPatterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning.
Roos CR, Nich C, Mun CJ, Mendonca J, Babuscio TA, Witkiewitz K, Carroll KM, Kiluk BD. Patterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning. Journal Of Studies On Alcohol And Drugs 2019, 80: 431-440. PMID: 31495380, PMCID: PMC6739643, DOI: 10.15288/jsad.2019.80.431.Peer-Reviewed Original ResearchDouble‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2018
Randomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes
Kiluk BD, Nich C, Buck MB, Devore KA, Frankforter TL, LaPaglia DM, Muvvala SB, Carroll KM. Randomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes. American Journal Of Psychiatry 2018, 175: 853-863. PMID: 29792052, PMCID: PMC6120780, DOI: 10.1176/appi.ajp.2018.17090978.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapySubstance use disordersComputer-based cognitive behavioral therapyUse disordersMinimal clinical monitoringTreatment-seeking populationTreatment-seeking outpatientsDSM-IV-TR criteriaCBT groupFrequency of substanceStandard outpatient careCBT4CBTStand-alone treatmentDiverse sampleStandard outpatient treatmentCurrent substance use disorderBehavioral conceptsBetter learningSubstance abuseHeterogeneous sampleUp OutcomesHigh dropout ratePrevious trialsSix-month followClinical trials
2016
Just Showing Up Is Not Enough: Homework Adherence and Outcome in Cognitive–Behavioral Therapy for Cocaine Dependence
Decker SE, Kiluk BD, Frankforter T, Babuscio T, Nich C, Carroll KM. Just Showing Up Is Not Enough: Homework Adherence and Outcome in Cognitive–Behavioral Therapy for Cocaine Dependence. Journal Of Consulting And Clinical Psychology 2016, 84: 907-912. PMID: 27454780, PMCID: PMC5341374, DOI: 10.1037/ccp0000126.Peer-Reviewed Original ResearchConceptsUrine toxicology screenCognitive behavioral therapyCocaine use outcomesHomework adherenceTreatment attendanceToxicology screenCocaine useUse outcomesMultiple logistic regressionBaseline cocaine useVariety of disordersCocaine use severityTreatment endClinical trialsCocaine use frequencyImproved outcomesCocaine dependenceLogistic regressionCBT sessionsAdherenceUse severityPrior studiesGreater reductionOutcomesTreatmentThe effectiveness and cost of clinical supervision for motivational interviewing: A randomized controlled trial
Martino S, Paris M, Añez L, Nich C, Canning-Ball M, Hunkele K, Olmstead TA, Carroll KM. The effectiveness and cost of clinical supervision for motivational interviewing: A randomized controlled trial. Journal Of Substance Use And Addiction Treatment 2016, 68: 11-23. PMID: 27431042, PMCID: PMC4955716, DOI: 10.1016/j.jsat.2016.04.005.Peer-Reviewed Original ResearchConceptsOutpatient substance abuse programsSubstance abuse programsEvidence-based practiceHybrid type 2Substance abstinenceSubstance use differencesType 2CliniciansAbuse programsMotivational interviewingGreater increaseMI strategiesTrialsClinical supervisionMI performanceMIAClient retentionAbstinence
2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMenWhat Happens in Treatment Doesn’t Stay in Treatment: Cocaine Abstinence During Treatment Is Associated With Fewer Problems at Follow-Up
Kiluk BD, Nich C, Witkiewitz K, Babuscio TA, Carroll KM. What Happens in Treatment Doesn’t Stay in Treatment: Cocaine Abstinence During Treatment Is Associated With Fewer Problems at Follow-Up. Journal Of Consulting And Clinical Psychology 2014, 82: 619-627. PMID: 24635550, PMCID: PMC4115028, DOI: 10.1037/a0036245.Peer-Reviewed Original ResearchToward empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes
Carroll KM, Kiluk BD, Nich C, DeVito EE, Decker S, LaPaglia D, Duffey D, Babuscio TA, Ball SA. Toward empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes. Drug And Alcohol Dependence 2014, 137: 3-19. PMID: 24556275, PMCID: PMC4042667, DOI: 10.1016/j.drugalcdep.2014.01.012.Peer-Reviewed Original Research
2013
An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence–contingent incentives and cognitive behavioral therapy
Krishnan-Sarin S, Cavallo DA, Cooney JL, Schepis TS, Kong G, Liss TB, Liss AK, McMahon TJ, Nich C, Babuscio T, Rounsaville BJ, Carroll KM. An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence–contingent incentives and cognitive behavioral therapy. Drug And Alcohol Dependence 2013, 132: 346-351. PMID: 23523130, PMCID: PMC3748248, DOI: 10.1016/j.drugalcdep.2013.03.002.Peer-Reviewed Original ResearchConceptsSmoking cessation interventionCognitive behavioral therapyAbstinence-contingent incentivesAdolescent smokersCessation interventionsBehavioral therapyCigarette useEffective smoking cessation interventionsUrine cotinine levelsPoint prevalence abstinenceShort-term abstinenceSecondary outcomesCotinine levelsPrimary outcomeCessation treatmentCessation barriersCessation skillsFirst cigaretteFollow-upSmokersHigher abstinenceSurvival analysisNovel interventionsFour weeksHigh schoolDevelopment of the Therapist Empathy Scale
Decker SE, Nich C, Carroll KM, Martino S. Development of the Therapist Empathy Scale. Behavioural And Cognitive Psychotherapy 2013, 42: 339-354. PMID: 23481373, PMCID: PMC3748263, DOI: 10.1017/s1352465813000039.Peer-Reviewed Original ResearchConceptsTherapist empathyEmpathy ScaleMotivational interviewingInternal consistencyDiscriminant validityMI-inconsistent behaviorsConfirmatory factor analysisSingle-factor solutionDifferent psychotherapy approachesInter-rater reliabilityTraining trialsPsychotherapy approachesWatson's workConvergent validityEmpathyExcellent inter-rater reliabilityObserver rating scaleCompetence scoresCriterion validityTES scoresClient outcomesClient sessionsFactor analysisNonsignificant correlationRating Scale
2012
Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial
Carroll KM, Nich C, Shi JM, Eagan D, Ball SA. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial. Drug And Alcohol Dependence 2012, 126: 224-231. PMID: 22695473, PMCID: PMC3461119, DOI: 10.1016/j.drugalcdep.2012.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcohol DrinkingCocaine-Related DisordersCounselingDemographyDiagnostic and Statistical Manual of Mental DisordersDisulfiramDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMethadoneNarcoticsOpiate Substitution TreatmentPatient ComplianceRegression AnalysisSelf-Help GroupsSocioeconomic FactorsSubstance Abuse DetectionTreatment OutcomeConceptsMethadone maintenance programEfficacy of disulfiramAlcohol use disorderCocaine useStandard counselingUse disordersCommunity-based methadone maintenance programRandomized placebo-controlled trialPlacebo-controlled trialCurrent alcohol use disorderTwelve-step facilitationCocaine-negative urinesLess cocaine useMethadone maintenanceStep FacilitationCocaine-dependent individualsPlaceboBetter outcomesDisulfiram efficacyTreatment approachesFactorial trialDisulfiramMaintenance programRelative efficacyCocaine usersCombining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less
Carroll KM, Nich C, LaPaglia DM, Peters EN, Easton CJ, Petry NM. Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less. Addiction 2012, 107: 1650-1659. PMID: 22404223, PMCID: PMC3509418, DOI: 10.1111/j.1360-0443.2012.03877.x.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyContingency managementHomework completionTime-line follow-back methodTreatment-seeking young adultsCannabis dependenceAddition of CBTSession attendanceOut-patient treatment programDays of cannabisCannabis treatment outcomesCBT outcomeBehavioral therapyAbstinence conditionSkills trainingRandom effects regression analysisAlone conditionCriminal justice systemUrine specimensTreatment programYoung adultsWeekly urineEffects regression analysisJustice systemAbstinence
2011
Mentorship for Alcohol Problems (MAP): A Peer to Peer Modular Intervention for Outpatients
Tracy K, Burton M, Miescher A, Galanter M, Babuscio T, Frankforter T, Nich C, Rounsaville B. Mentorship for Alcohol Problems (MAP): A Peer to Peer Modular Intervention for Outpatients. Alcohol And Alcoholism 2011, 47: 42-47. PMID: 22045903, PMCID: PMC3243439, DOI: 10.1093/alcalc/agr136.Peer-Reviewed Original ResearchConceptsOutpatient alcohol treatment programTreatment programSubstance useAlcohol problemsCommunity treatment programsAlcohol use disorderAlcohol treatment programsDelivery of treatmentReduction of alcoholStage IModular interventionNew interventionsPatient interestBiological measuresInterventionFocus groupsMindfulness training for smoking cessation: Results from a randomized controlled trial
Brewer JA, Mallik S, Babuscio TA, Nich C, Johnson HE, Deleone CM, Minnix-Cotton CA, Byrne SA, Kober H, Weinstein AJ, Carroll KM, Rounsaville BJ. Mindfulness training for smoking cessation: Results from a randomized controlled trial. Drug And Alcohol Dependence 2011, 119: 72-80. PMID: 21723049, PMCID: PMC3191261, DOI: 10.1016/j.drugalcdep.2011.05.027.Peer-Reviewed Original ResearchConceptsAbstinence ratesPoint prevalence abstinence ratesLong-term abstinence ratesCigarettes/dayCurrent standard treatmentEnd of treatmentPoint prevalence abstinenceAmerican Lung Association's FreedomMindfulness trainingPrimary outcomeCigarette smokingSmoking cessationStandard treatmentClinical trialsWeek 17Preventable deathsPsychiatric disordersSmoking treatmentCigarette useNicotine-dependent adultsTrialsCessationGroup formatTreatmentInitial trial
2008
Enduring effects of a computer-assisted training program for cognitive behavioral therapy: A 6-month follow-up of CBT4CBT
Carroll KM, Ball SA, Martino S, Nich C, Babuscio TA, Rounsaville BJ. Enduring effects of a computer-assisted training program for cognitive behavioral therapy: A 6-month follow-up of CBT4CBT. Drug And Alcohol Dependence 2008, 100: 178-181. PMID: 19041197, PMCID: PMC2742309, DOI: 10.1016/j.drugalcdep.2008.09.015.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral therapyComputer-assisted training programSubstance dependenceComputer-based trainingSubstance use outcomesComputer-assisted versionDrug useEnduring effectCBT4CBTUse outcomesRandomized clinical trialsTreatment retentionDurability of effectTraining programOutpatient communityStudy treatmentStandard treatmentOutpatient treatmentClinical trialsTreatment conditionsParticipantsSignificant differencesTreatmentRegression analysis
2007
Site Matters: Multisite Randomized Trial of Motivational Enhancement Therapy in Community Drug Abuse Clinics
Ball SA, Martino S, Nich C, Frankforter TL, Van Horn D, Crits-Christoph P, Woody GE, Obert JL, Farentinos C, Carroll KM. Site Matters: Multisite Randomized Trial of Motivational Enhancement Therapy in Community Drug Abuse Clinics. Journal Of Consulting And Clinical Psychology 2007, 75: 556-567. PMID: 17663610, PMCID: PMC2148493, DOI: 10.1037/0022-006x.75.4.556.Peer-Reviewed Original ResearchConceptsMotivational enhancement therapySubstance useEnhancement therapyBrief intervention conditionsOutpatient substance abuse programsSubstance use reductionDrug abuse clinicsSubstance abuse programsSession audiotapesRandomized trialsClinical trialsMultisite Randomized TrialSustained reductionTherapy phaseDrug usersPrimary alcohol usersAlcohol usersAbuse programsIntervention conditionSignificant increaseTherapyTrialsCAUOutpatientsClinic
2006
A randomized controlled pilot study of motivational interviewing for patients with psychotic and drug use disorders
Martino S, Carroll KM, Nich C, Rounsaville BJ. A randomized controlled pilot study of motivational interviewing for patients with psychotic and drug use disorders. Addiction 2006, 101: 1479-1492. PMID: 16968350, DOI: 10.1111/j.1360-0443.2006.01554.x.Peer-Reviewed Original ResearchConceptsStandard psychiatric interviewDrug treatment outcomesTreatment outcomesDrug usePilot studyMeasurements Primary outcomeDays of attendancePsychotropic medication adherenceCocaine-using groupPrimary drug useDrug use disordersProportion of participantsPartial hospital programDrug-related disordersImproved treatment outcomesSecondary drug usePrimary outcomeMedication adherencePsychiatric interviewHospital programTrial designUse disordersDual diagnosisMotivational interviewPrimary marijuana
2005
Motivational interviewing to improve treatment engagement and outcome in individuals seeking treatment for substance abuse: A multisite effectiveness study
Carroll KM, Ball SA, Nich C, Martino S, Frankforter TL, Farentinos C, Kunkel LE, Mikulich-Gilbertson SK, Morgenstern J, Obert JL, Polcin D, Snead N, Woody GE, Network F. Motivational interviewing to improve treatment engagement and outcome in individuals seeking treatment for substance abuse: A multisite effectiveness study. Drug And Alcohol Dependence 2005, 81: 301-312. PMID: 16169159, PMCID: PMC2386852, DOI: 10.1016/j.drugalcdep.2005.08.002.Peer-Reviewed Original ResearchConceptsClinical practiceCommunity-based treatment settingsCourse of treatmentStandard clinical practiceCommunity-based cliniciansForm of treatmentMultisite effectiveness studyMI techniquesMotivational interviewing techniquesSubstance use outcomesSession audiotapesEvaluation sessionsOutpatient treatmentClinical trialsImproved outcomesStandard interventionTreatment settingsTreatment engagementBehavioral therapyEffectiveness studiesSubstance abuseSame sessionUse outcomesHigher skill ratingsSubstance users
2002
Contingency Management to Enhance Naltrexone Treatment of Opioid Dependence: A Randomized Clinical Trial of Reinforcement Magnitude
Carroll KM, Sinha R, Nich C, Babuscio T, Rounsaville BJ. Contingency Management to Enhance Naltrexone Treatment of Opioid Dependence: A Randomized Clinical Trial of Reinforcement Magnitude. Experimental And Clinical Psychopharmacology 2002, 10: 54-63. PMID: 11866252, DOI: 10.1037/1064-1297.10.1.54.Peer-Reviewed Original ResearchConceptsNaltrexone treatmentContingency managementOpioid-dependent individualsSignificant reductionReinforcement magnitudeOpioid useAvailable pharmacotherapiesNaltrexone maintenanceOpioid dependenceClinical trialsCM groupBehavioral therapyNaltrexoneTreatmentCM conditionRelative benefitsParticipantsPharmacotherapyTherapyTrialsWeeks