2023
Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2023, 18: 55. PMID: 37726823, PMCID: PMC10510167, DOI: 10.1186/s13722-023-00407-9.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAlcoholismCrisis InterventionEthanolHospitalizationHumansPatient DischargeRandomized Controlled Trials as TopicConceptsPost-hospital dischargeCognitive behavioral therapySelf-reported alcohol useBrief Negotiation InterviewUse disordersAlcohol use outcomesComputer-based trainingDays post-hospital dischargeAlcohol use disorderBehavioral therapyInitiation of medicationHealth care utilizationHealth promotion advocatesTreatment engagementUse outcomesAlcohol useSecondary outcomesHospitalized patientsPrimary outcomeCare utilizationClinical trialsAcademic hospitalExploratory outcomesAUDProcess evaluation
2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchChange in employment status and cocaine use treatment outcomes: A secondary analysis across six clinical trials
Miguel AQC, Kiluk BD, Roos CR, Babuscio TA, Nich C, Mari JJ, Carroll KM. Change in employment status and cocaine use treatment outcomes: A secondary analysis across six clinical trials. Journal Of Substance Use And Addiction Treatment 2019, 106: 89-96. PMID: 31540616, PMCID: PMC6785033, DOI: 10.1016/j.jsat.2019.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultCocaine-Related DisordersEmploymentFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicTreatment OutcomeUnemploymentConceptsTreatment outcomesSociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race
Miguel AQC, Jordan A, Kiluk BD, Nich C, Babuscio TA, Mari JJ, Carroll KM. Sociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race. Journal Of Substance Use And Addiction Treatment 2019, 106: 65-72. PMID: 31540613, PMCID: PMC6756185, DOI: 10.1016/j.jsat.2019.08.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack PeopleCocaine-Related DisordersFemaleHumansMaleMiddle AgedPatient Acceptance of Health CareRandomized Controlled Trials as TopicSex FactorsWhite PeopleConceptsCocaine use disorderTreatment trialsTreatment outcomesUse disordersWhite womenTreatment outcome indicatorsPoor overall outcomeClinical outcome differencesRandomized clinical trialsFocused treatment approachMore effective treatmentsDifferent psychosocial issuesSubstance use problemsSubgroup of individualsBaseline characteristicsPoor outcomePsychiatric comorbidityClinical trialsHigh prevalenceSociodemographic statusEffective treatmentOutcome differencesTreatment approachesPsychosocial issuesCocaine usePatterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning.
Roos CR, Nich C, Mun CJ, Mendonca J, Babuscio TA, Witkiewitz K, Carroll KM, Kiluk BD. Patterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning. Journal Of Studies On Alcohol And Drugs 2019, 80: 431-440. PMID: 31495380, PMCID: PMC6739643, DOI: 10.15288/jsad.2019.80.431.Peer-Reviewed Original ResearchAdultCocaineCocaine-Related DisordersFemaleFollow-Up StudiesHumansMaleRandomized Controlled Trials as TopicSelf MedicationTreatment OutcomeYoung Adult
2016
Just Showing Up Is Not Enough: Homework Adherence and Outcome in Cognitive–Behavioral Therapy for Cocaine Dependence
Decker SE, Kiluk BD, Frankforter T, Babuscio T, Nich C, Carroll KM. Just Showing Up Is Not Enough: Homework Adherence and Outcome in Cognitive–Behavioral Therapy for Cocaine Dependence. Journal Of Consulting And Clinical Psychology 2016, 84: 907-912. PMID: 27454780, PMCID: PMC5341374, DOI: 10.1037/ccp0000126.Peer-Reviewed Original ResearchMeSH KeywordsAdultCocaine-Related DisordersCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedOutcome Assessment, Health CarePatient CompliancePractice, PsychologicalRandomized Controlled Trials as TopicSubstance Abuse DetectionConceptsUrine toxicology screenCognitive behavioral therapyCocaine use outcomesHomework adherenceTreatment attendanceToxicology screenCocaine useUse outcomesMultiple logistic regressionBaseline cocaine useVariety of disordersCocaine use severityTreatment endClinical trialsCocaine use frequencyImproved outcomesCocaine dependenceLogistic regressionCBT sessionsAdherenceUse severityPrior studiesGreater reductionOutcomesTreatment
2014
What Happens in Treatment Doesn’t Stay in Treatment: Cocaine Abstinence During Treatment Is Associated With Fewer Problems at Follow-Up
Kiluk BD, Nich C, Witkiewitz K, Babuscio TA, Carroll KM. What Happens in Treatment Doesn’t Stay in Treatment: Cocaine Abstinence During Treatment Is Associated With Fewer Problems at Follow-Up. Journal Of Consulting And Clinical Psychology 2014, 82: 619-627. PMID: 24635550, PMCID: PMC4115028, DOI: 10.1037/a0036245.Peer-Reviewed Original ResearchCocaineCocaine-Related DisordersDopamine Uptake InhibitorsFemaleFollow-Up StudiesHumansMaleRandomized Controlled Trials as TopicSeverity of Illness IndexAssessment concordance and predictive validity of self‐report and biological assay of cocaine use in treatment trials
Decker SE, Frankforter T, Babuscio T, Nich C, Ball SA, Carroll KM. Assessment concordance and predictive validity of self‐report and biological assay of cocaine use in treatment trials. American Journal On Addictions 2014, 23: 466-474. PMID: 24628970, PMCID: PMC4139466, DOI: 10.1111/j.1521-0391.2014.12132.x.Peer-Reviewed Original ResearchMeSH KeywordsCocaineFemaleHumansMalePredictive Value of TestsRandomized Controlled Trials as TopicSelf ReportSubstance Abuse DetectionUrine Specimen CollectionConceptsPredictive validityPsychosocial outcomesCocaine useSelf-report assessmentsSelf-report accuracyCocaine treatment trialSelf-reported dataPost-treatment pointSelf-reported cocaine useMethod variancePost-treatment outcomesTreatment trialsTreatment completionAssessment methodsUrinalysis resultsValidityRandomized clinical trials
2011
A Methodological Analysis of Randomized Clinical Trials of Computer-Assisted Therapies for Psychiatric Disorders: Toward Improved Standards for an Emerging Field
Kiluk BD, Sugarman DE, Nich C, Gibbons CJ, Martino S, Rounsaville BJ, Carroll KM. A Methodological Analysis of Randomized Clinical Trials of Computer-Assisted Therapies for Psychiatric Disorders: Toward Improved Standards for an Emerging Field. American Journal Of Psychiatry 2011, 168: 790-799. PMID: 21536689, PMCID: PMC3607199, DOI: 10.1176/appi.ajp.2011.10101443.Peer-Reviewed Original ResearchMeSH KeywordsAdultEvidence-Based MedicineHumansMental DisordersPsychotherapyRandomized Controlled Trials as TopicReference StandardsTherapy, Computer-AssistedTreatment OutcomeUnited StatesConceptsComputer-assisted therapyRandomized clinical trialsPsychiatric disordersClinical trialsMethodological qualityEvidence-based behavioral therapiesMethodological Quality IndexPotential adverse eventsEvidence-based therapiesAxis I DisordersAdult psychiatric disordersMethodological quality scoreEvidence-based interventionsAdverse eventsTreat principleRandomized trialsI disordersStudy qualityTreatment exposureTherapyBehavioral therapyCost-effective strategyDisordersTrialsCurrent standard
2008
What is usual about “treatment-as-usual”? Data from two multisite effectiveness trials
Santa Ana EJ, Martino S, Ball SA, Nich C, Frankforter TL, Carroll KM. What is usual about “treatment-as-usual”? Data from two multisite effectiveness trials. Journal Of Substance Use And Addiction Treatment 2008, 35: 369-379. PMID: 18337053, PMCID: PMC2712113, DOI: 10.1016/j.jsat.2008.01.003.Peer-Reviewed Original ResearchConceptsEffectiveness trialDrug Abuse Clinical Trials NetworkSubstance useMultisite effectiveness trialClinical Trials NetworkStandard clinical practiceParticipants' substance useCommunity-based drug abuse treatmentDrug abuse treatmentNumber of interventionsSubstance use outcomesPatient outcomesClinical practiceTrials NetworkAbuse treatmentUse outcomesNational InstituteSocial functioningTreatmentTrialsOpen-ended questionsOutcomesStandard practiceEarly stagesEarly sessionsMaking consent more informed: preliminary results from a multiple-choice test among probation-referred marijuana users entering a randomized clinical trial.
Rounsaville DB, Hunkele K, Easton CJ, Nich C, Carroll KM. Making consent more informed: preliminary results from a multiple-choice test among probation-referred marijuana users entering a randomized clinical trial. The Journal Of The American Academy Of Psychiatry And The Law 2008, 36: 354-9. PMID: 18802184, PMCID: PMC2562888.Peer-Reviewed Original ResearchMeSH KeywordsCognitive Behavioral TherapyFemaleHumansInformed ConsentMaleMarijuana AbusePsychological TestsRandomized Controlled Trials as TopicUnited StatesYoung Adult
2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultCocaine-Related DisordersDisulfiramDrug Therapy, CombinationEnzyme InhibitorsFemaleHumansMaleMethadoneNarcotic AntagonistsRandomized Controlled Trials as TopicSex FactorsTreatment OutcomeConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential response
2002
‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data
Nich C, Carroll KM. ‘Intention-to-treat’ meets ‘missing data’: implications of alternate strategies for analyzing clinical trials data. Drug And Alcohol Dependence 2002, 68: 121-130. PMID: 12234641, PMCID: PMC3651592, DOI: 10.1016/s0376-8716(02)00111-4.Peer-Reviewed Original ResearchMeSH KeywordsData Interpretation, StatisticalHumansModels, StatisticalPatient DropoutsRandomized Controlled Trials as TopicResearch DesignSubstance-Related DisordersTreatment OutcomeConceptsEffectiveness of treatmentTreat analysisClinical trialsRandomized clinical trialsClinical trial dataStudy treatmentProtocol violationsTreat strategyTreatment retentionPoint of dropoutTime-varying covariatesTrial dataCocaine dependenceIntended durationParticipant dropoutRelative efficacyTrialsTreatmentMultiple analytic strategiesRetention outcomesDurationFull durationStrategy 1Analytic strategiesSubstantial levels