2023
Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2023, 18: 55. PMID: 37726823, PMCID: PMC10510167, DOI: 10.1186/s13722-023-00407-9.Peer-Reviewed Original ResearchConceptsPost-hospital dischargeCognitive behavioral therapySelf-reported alcohol useBrief Negotiation InterviewUse disordersAlcohol use outcomesComputer-based trainingDays post-hospital dischargeAlcohol use disorderBehavioral therapyInitiation of medicationHealth care utilizationHealth promotion advocatesTreatment engagementUse outcomesAlcohol useSecondary outcomesHospitalized patientsPrimary outcomeCare utilizationClinical trialsAcademic hospitalExploratory outcomesAUDProcess evaluation
2018
Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.
Paris M, Silva M, Añez-Nava L, Jaramillo Y, Kiluk BD, Gordon MA, Nich C, Frankforter T, Devore K, Ball SA, Carroll KM. Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. American Journal Of Public Health 2018, 108: 1535-1542. PMID: 30252519, PMCID: PMC6187780, DOI: 10.2105/ajph.2018.304571.Peer-Reviewed Original ResearchConceptsSubstance use disordersCognitive-behavioral treatmentUse disordersSubstance use outcomesClinical trialsWeb-based cognitive behavioral therapyCurrent substance use disorderUse outcomesRandomized clinical trialsStandard outpatient treatmentEvidence-based treatmentsCognitive behavioral therapyPrimary outcomeStandard treatmentOutpatient treatmentStandard outpatientTreatment completionHealth disparitiesBehavioral therapyBehavioral treatmentAddiction treatmentTreatment-seeking individualsGreater reductionTreatmentDisorders
2016
A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence
Carroll KM, Nich C, Petry NM, Eagan DA, Shi JM, Ball SA. A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence. Drug And Alcohol Dependence 2016, 160: 135-142. PMID: 26817621, PMCID: PMC4767616, DOI: 10.1016/j.drugalcdep.2015.12.036.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCocaine outcomesCocaine dependenceCombination of CMDouble-blind clinical trialBehavioral therapyCommunity-based outpatient clinicsUrine sample testingBlind clinical trialSustained treatment effectContingency managementDSM-IV criteriaRandomized factorial trialCurrent cocaine dependenceWeekly individual sessionsCocaine use disorderSecondary outcomesPrimary outcomeYear followOutpatient clinicAddition of disulfiramClinical trialsUse disordersCBT treatmentFactorial trial
2013
An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence–contingent incentives and cognitive behavioral therapy
Krishnan-Sarin S, Cavallo DA, Cooney JL, Schepis TS, Kong G, Liss TB, Liss AK, McMahon TJ, Nich C, Babuscio T, Rounsaville BJ, Carroll KM. An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence–contingent incentives and cognitive behavioral therapy. Drug And Alcohol Dependence 2013, 132: 346-351. PMID: 23523130, PMCID: PMC3748248, DOI: 10.1016/j.drugalcdep.2013.03.002.Peer-Reviewed Original ResearchConceptsSmoking cessation interventionCognitive behavioral therapyAbstinence-contingent incentivesAdolescent smokersCessation interventionsBehavioral therapyCigarette useEffective smoking cessation interventionsUrine cotinine levelsPoint prevalence abstinenceShort-term abstinenceSecondary outcomesCotinine levelsPrimary outcomeCessation treatmentCessation barriersCessation skillsFirst cigaretteFollow-upSmokersHigher abstinenceSurvival analysisNovel interventionsFour weeksHigh school
2011
Utilizing Peer Mentorship to Engage High Recidivism Substance-Abusing Patients in Treatment
Tracy K, Burton M, Nich C, Rounsaville B. Utilizing Peer Mentorship to Engage High Recidivism Substance-Abusing Patients in Treatment. The American Journal Of Drug And Alcohol Abuse 2011, 37: 525-531. PMID: 21851202, DOI: 10.3109/00952990.2011.600385.Peer-Reviewed Original ResearchConceptsSubstance-using patientsSubstance abuse patientsSubstance use disordersPrimary outcomeOutpatient treatmentOutpatient appointmentsLack of attendanceTreatment appointmentsHospital settingPast diagnosisUse disordersTreatment attendanceSubstance abusePatientsTreatmentHigh recidivismPeer mentorshipTauAddiction problemsAppointmentsAttendanceMindfulness training for smoking cessation: Results from a randomized controlled trial
Brewer JA, Mallik S, Babuscio TA, Nich C, Johnson HE, Deleone CM, Minnix-Cotton CA, Byrne SA, Kober H, Weinstein AJ, Carroll KM, Rounsaville BJ. Mindfulness training for smoking cessation: Results from a randomized controlled trial. Drug And Alcohol Dependence 2011, 119: 72-80. PMID: 21723049, PMCID: PMC3191261, DOI: 10.1016/j.drugalcdep.2011.05.027.Peer-Reviewed Original ResearchConceptsAbstinence ratesPoint prevalence abstinence ratesLong-term abstinence ratesCigarettes/dayCurrent standard treatmentEnd of treatmentPoint prevalence abstinenceAmerican Lung Association's FreedomMindfulness trainingPrimary outcomeCigarette smokingSmoking cessationStandard treatmentClinical trialsWeek 17Preventable deathsPsychiatric disordersSmoking treatmentCigarette useNicotine-dependent adultsTrialsCessationGroup formatTreatmentInitial trialPrimary outcomes in two randomized controlled trials of treatments for cannabis use disorders
Peters EN, Nich C, Carroll KM. Primary outcomes in two randomized controlled trials of treatments for cannabis use disorders. Drug And Alcohol Dependence 2011, 118: 408-416. PMID: 21620591, PMCID: PMC3189305, DOI: 10.1016/j.drugalcdep.2011.04.021.Peer-Reviewed Original Research
2010
Teaching community program clinicians motivational interviewing using expert and train‐the‐trainer strategies
Martino S, Ball SA, Nich C, Canning‐Ball M, Rounsaville BJ, Carroll KM. Teaching community program clinicians motivational interviewing using expert and train‐the‐trainer strategies. Addiction 2010, 106: 428-441. PMID: 20925684, PMCID: PMC3017235, DOI: 10.1111/j.1360-0443.2010.03135.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultClinical CompetenceConnecticutEducation, Medical, ContinuingEducational MeasurementFemaleHumansInterview, PsychologicalMaleMiddle AgedMotivationProgram DevelopmentProgram EvaluationRegression AnalysisSubstance Abuse Treatment CentersSubstance-Related DisordersTeachingTeaching MaterialsTechnology TransferConceptsClinical trial standardsTreatment programPercentage of cliniciansMental health treatment programsCommunity treatment programsMI adherencePrimary outcomeClinician adherenceProgram cliniciansMI performanceTrainer strategyCliniciansAddiction treatmentTrial standardsTrainer approachAdherenceTT conditionsHigh percentageTreatmentSkill-building workshopsTTExMIEffective strategyStudy
2007
Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression
Petrakis I, Ralevski E, Nich C, Levinson C, Carroll K, Poling J, Rounsaville B. Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression. Journal Of Clinical Psychopharmacology 2007, 27: 160-165. PMID: 17414239, DOI: 10.1097/jcp.0b13e3180337fcb.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DeterrentsAlcoholismBipolar DisorderCocaine-Related DisordersComorbidityConnecticutDepressive Disorder, MajorDisulfiramDouble-Blind MethodDrug Therapy, CombinationFemaleGamma-GlutamyltransferaseGastrointestinal DiseasesHumansMaleMassachusettsMiddle AgedNaltrexoneNarcotic AntagonistsPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaStress Disorders, Post-TraumaticTreatment OutcomeVeteransConceptsPsychiatric symptomsAlcohol dependenceAlcohol use outcomesMajor depressionPsychiatric disordersVeterans Administration Outpatient ClinicHamilton Depression Rating ScaleAxis I psychiatric disordersCommon co-occurring disordersDouble-blind randomizationUse outcomesGamma-glutamyltransferase levelsDepression Rating ScaleFourth Edition criteriaDiagnosis of depressionCo-occurring disordersSpecific psychiatric symptomsTreatment of alcoholismAlcohol use disorderOpen randomizationAdverse eventsMedication groupSecondary outcomesPrimary outcomeMedication treatment
2006
A randomized controlled pilot study of motivational interviewing for patients with psychotic and drug use disorders
Martino S, Carroll KM, Nich C, Rounsaville BJ. A randomized controlled pilot study of motivational interviewing for patients with psychotic and drug use disorders. Addiction 2006, 101: 1479-1492. PMID: 16968350, DOI: 10.1111/j.1360-0443.2006.01554.x.Peer-Reviewed Original ResearchConceptsStandard psychiatric interviewDrug treatment outcomesTreatment outcomesDrug usePilot studyMeasurements Primary outcomeDays of attendancePsychotropic medication adherenceCocaine-using groupPrimary drug useDrug use disordersProportion of participantsPartial hospital programDrug-related disordersImproved treatment outcomesSecondary drug usePrimary outcomeMedication adherencePsychiatric interviewHospital programTrial designUse disordersDual diagnosisMotivational interviewPrimary marijuana
2005
Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, Group V. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders. Biological Psychiatry 2005, 57: 1128-1137. PMID: 15866552, DOI: 10.1016/j.biopsych.2005.02.016.Peer-Reviewed Original ResearchConceptsPsychiatric disordersAlcohol dependenceVeterans Administration Outpatient ClinicAxis I psychiatric disordersComorbid psychiatric disordersUse of disulfiramTreatment of alcoholismEvent Monitoring SystemAlcohol-dependent individualsActive medicationAdverse eventsSecondary outcomesPrimary outcomeMedication complianceOutpatient clinicSignificant group differencesGGT levelsMedication studiesPsychiatric symptomsAlcohol consumptionNaltrexoneAlcohol cravingDrug AdministrationConsecutive weeksPlacebo
2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential response