2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMen
2012
Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial
Carroll KM, Nich C, Shi JM, Eagan D, Ball SA. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial. Drug And Alcohol Dependence 2012, 126: 224-231. PMID: 22695473, PMCID: PMC3461119, DOI: 10.1016/j.drugalcdep.2012.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcohol DrinkingCocaine-Related DisordersCounselingDemographyDiagnostic and Statistical Manual of Mental DisordersDisulfiramDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMethadoneNarcoticsOpiate Substitution TreatmentPatient ComplianceRegression AnalysisSelf-Help GroupsSocioeconomic FactorsSubstance Abuse DetectionTreatment OutcomeConceptsMethadone maintenance programEfficacy of disulfiramAlcohol use disorderCocaine useStandard counselingUse disordersCommunity-based methadone maintenance programRandomized placebo-controlled trialPlacebo-controlled trialCurrent alcohol use disorderTwelve-step facilitationCocaine-negative urinesLess cocaine useMethadone maintenanceStep FacilitationCocaine-dependent individualsPlaceboBetter outcomesDisulfiram efficacyTreatment approachesFactorial trialDisulfiramMaintenance programRelative efficacyCocaine users
2007
The Impact of Personality Disorders on Alcohol‐Use Outcomes in a Pharmacotherapy Trial for Alcohol Dependence and Comorbid Axis I Disorders
Ralevski E, Ball S, Nich C, Limoncelli D, Petrakis I. The Impact of Personality Disorders on Alcohol‐Use Outcomes in a Pharmacotherapy Trial for Alcohol Dependence and Comorbid Axis I Disorders. American Journal On Addictions 2007, 16: 443-449. PMID: 18058408, DOI: 10.1080/10550490701643336.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcoholismAntisocial Personality DisorderBehavior, AddictiveBorderline Personality DisorderComorbidityDiagnostic and Statistical Manual of Mental DisordersDisulfiramFemaleHumansMaleMental DisordersMiddle AgedNaltrexoneNarcotic AntagonistsPatient CompliancePersonality DisordersPlacebosPsychiatric Status Rating ScalesTreatment OutcomeConceptsBorderline personality disorderAxis I DisordersAlcohol dependenceAlcohol use outcomesPersonality disorderI disordersAxis IComorbid Axis I disordersContext of pharmacotherapyAxis II disordersMajor Axis IMedication trialsPharmacotherapy trialsPoor responseOutcome measuresPatientsNaltrexoneAlcohol useDiagnosisUse outcomesDiagnosis of antisocialDisordersDisulfiramOutcomesASPD
2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential responseCost effectiveness of disulfiram Treating cocaine use in methadone-maintained patients
Jofre-Bonet M, Sindelar JL, Petrakis IL, Nich C, Frankforter T, Rounsaville BJ, Carroll KM. Cost effectiveness of disulfiram Treating cocaine use in methadone-maintained patients. Journal Of Substance Use And Addiction Treatment 2004, 26: 225-232. PMID: 15063917, PMCID: PMC3662046, DOI: 10.1016/s0740-5472(04)00004-2.Peer-Reviewed Original ResearchConceptsMethadone treatmentClinical trialsCocaine useDouble-blind clinical trialCocaine dependenceStandard methadone treatmentBlind clinical trialMethadone-maintained patientsRandomized clinical trialsOpioid-dependent subjectsMethadone-maintained opiate addictsStandard treatmentOutcome measuresOpioid addictsPromising treatmentOpiate addictsIncremental costDisulfiramAdditional treatmentNumber of daysTrialsTreatmentCost effectivenessEconomic evaluationAddicts