2023
Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection
Choi J, Jung S, Choi I, Kang Y, Lee D, Lee S, Park S, Song C, Choi I, Lee J, Oh C. Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection. Veterinary Sciences 2023, 10: 380. PMID: 37368766, PMCID: PMC10302841, DOI: 10.3390/vetsci10060380.Peer-Reviewed Original ResearchFeline infectious peritonitisFeline coronavirus infectionSystemic granulomatous inflammationDose-dependent mannerFCoV replicationGranulomatous inflammationAntiviral effectInfectious peritonitisPotential treatmentFatal diseaseHigh mortalityCoronavirus infectionFeline coronavirusAntiviral propertiesWorth further investigationFurther investigationCellular levelFCoV.Inhibition efficacyPeritonitisInflammationRottlerinLater stages
2021
Inhibition of endocytosis of porcine reproductive and respiratory syndrome virus by rottlerin and its potential prophylactic administration in piglets
Kang Y, Oh C, Ahn S, Choi J, Choi H, Lee S, Choi I, Song C, Lee J, Park S. Inhibition of endocytosis of porcine reproductive and respiratory syndrome virus by rottlerin and its potential prophylactic administration in piglets. Antiviral Research 2021, 195: 105191. PMID: 34678331, DOI: 10.1016/j.antiviral.2021.105191.Peer-Reviewed Original ResearchConceptsAnti-PRRSV effectPRRSV infectionBlood viral loadRespiratory syndrome virusInterstitial pneumoniaProphylactic administrationClinical scoresViral loadProphylactic treatmentAntiviral effectAntiviral agentsPRRSV internalizationViral replicationUntreated pigsProtein kinase CTreatmentΔ phosphorylationEntry pathwayInfectionInhibition of endocytosisRottlerinKinase CLimited studiesVivoPigs