2021
Effects of Atrial Fibrillation on Heart Failure Outcomes and NT-proBNP Levels in the GUIDE-IT Trial
Chouairi F, Pacor J, Miller PE, Fuery MA, Caraballo C, Sen S, Leifer ES, Felker GM, Fiuzat M, O’Connor C, Januzzi JL, Friedman DJ, Desai NR, Ahmad T, Freeman JV. Effects of Atrial Fibrillation on Heart Failure Outcomes and NT-proBNP Levels in the GUIDE-IT Trial. Mayo Clinic Proceedings Innovations Quality & Outcomes 2021, 5: 447-455. PMID: 33997640, PMCID: PMC8105522, DOI: 10.1016/j.mayocpiqo.2021.02.005.Peer-Reviewed Original ResearchNT-proBNP levelsReduced ejection fractionAtrial fibrillationHF hospitalizationHeart failureEjection fractionMedical therapyN-terminal pro-B-type natriuretic peptideOptimal guideline-directed medical therapyPro-B-type natriuretic peptideGuideline-directed medical therapyHigher NT-proBNP concentrationsHigher NT-proBNP levelsGUIDE-IT trialMedical therapy useHeart failure outcomesHeart Failure TrialPrevalent atrial fibrillationNT-proBNP concentrationsType natriuretic peptideEvidence-based therapiesCardiovascular deathAF patientsTherapy useFailure Trial
2019
Clinical Implications of the New York Heart Association Classification
Caraballo C, Desai NR, Mulder H, Alhanti B, Wilson FP, Fiuzat M, Felker GM, Piña IL, O'Connor CM, Lindenfeld J, Januzzi JL, Cohen LS, Ahmad T. Clinical Implications of the New York Heart Association Classification. Journal Of The American Heart Association 2019, 8: e014240. PMID: 31771438, PMCID: PMC6912957, DOI: 10.1161/jaha.119.014240.Peer-Reviewed Original ResearchConceptsNew York Heart Association classificationHF clinical trialsNYHA class IIVentricular ejection fractionGUIDE-ITHeart failureNYHA classWalk distanceEjection fractionRisk stratificationHF-ACTIONAssociation classificationClinical trialsMinute ventilation-carbon dioxide production relationshipKansas City Cardiomyopathy Questionnaire scoreClass IIMulticenter National InstituteNYHA class IIINT-proBNP levelsKaplan-Meier curvesLog-rank testClinical trial eligibilityWilcoxon rank sum testMaximal oxygen uptakeRank sum test