2004
Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study
Nelson JC, Mazure CM, Jatlow PI, Bowers MB, Price LH. Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study. Biological Psychiatry 2004, 55: 296-300. PMID: 14744472, DOI: 10.1016/j.biopsych.2003.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAdultAntidepressive Agents, Second-GenerationAntidepressive Agents, TricyclicChromatography, High Pressure LiquidDepressive DisorderDesipramineDouble-Blind MethodDrug Therapy, CombinationFemaleFluoxetineHumansMaleMiddle AgedNorepinephrinePsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsSerotoninTreatment OutcomeConceptsMontgomery-Asberg Depression Rating ScaleHamilton Depression Rating Scale scoresDepression Rating Scale scoresNonpsychotic unipolar major depressionPatient withdrew consentTreatment-resistant patientsWeeks of hospitalizationWeeks of treatmentCombination of fluoxetineOnset of actionAdequate plasma levelsDouble-blind conditionsDepression Rating ScaleTreatment of depressionRating Scale scoresUnipolar major depressionDrug plasma concentrationsDMI doseWithdrew consentAntidepressant medicationRandomized studyReuptake inhibitionSerotonergic agentsPlasma levelsMajor depression
1997
Chronic neuroleptic exposure in bipolar outpatients.
Sernyak MJ, Godleski LS, Griffin RA, Mazure CM, Woods SW. Chronic neuroleptic exposure in bipolar outpatients. The Journal Of Clinical Psychiatry 1997, 58: 193-5. PMID: 9184612, DOI: 10.4088/jcp.v58n0503.Peer-Reviewed Original ResearchConceptsChronic neuroleptic exposureNeuroleptic exposureBipolar outpatientsBipolar disorderConnecticut Mental Health CenterChronic neuroleptic administrationMental health centersComputerized administrative databasesNeuroleptic medicationChlorpromazine equivalentsNeuroleptic administrationChronic useMedical recordsAdministrative databasesNeuroleptic dosageHealth centersBipolar patientsPatientsOutpatientsReview criteriaDisordersExposurePast yearMedicationsDiagnosis
1992
Lithium in combination with perphenazine: effect on plasma monoamine metabolites
Bowers M, Mazure C, Nelson J, Jatlow P. Lithium in combination with perphenazine: effect on plasma monoamine metabolites. Biological Psychiatry 1992, 32: 1102-1107. PMID: 1477190, DOI: 10.1016/0006-3223(92)90190-b.Peer-Reviewed Original ResearchValproate Treatment of Older Psychotic Patients with Organic Mental Syndromes and Behavioral Dyscontrol
Mazure CM, Druss BG, Cellar JS. Valproate Treatment of Older Psychotic Patients with Organic Mental Syndromes and Behavioral Dyscontrol. Journal Of The American Geriatrics Society 1992, 40: 914-916. PMID: 1512389, DOI: 10.1111/j.1532-5415.1992.tb01990.x.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAggressionComorbidityDrug Therapy, CombinationFemaleHumansNeurocognitive DisordersPsychotic DisordersSeverity of Illness IndexValproic AcidDrug-responsive symptoms during early neuroleptic treatment
Mazure C, Nelson J, Jatlow P, Bowers M. Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Research 1992, 41: 147-154. PMID: 1574541, DOI: 10.1016/0165-1781(92)90106-d.Peer-Reviewed Original ResearchConceptsDrug responseEarly drug responseDays of treatmentIdentification of symptomsNeuroleptic treatmentSerum concentrationsNeuroleptic drugsNeurochemical mechanismsPositive symptomsSymptomsProgressive phaseDrug actionConceptual disorganizationMultiple regression analysisRegression analysisTreatmentPsychosisSeverityHallucinationsResponse
1991
A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression
Nelson JC, Mazure CM, Bowers MB, Jatlow PI. A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression. JAMA Psychiatry 1991, 48: 303-307. PMID: 2009031, DOI: 10.1001/archpsyc.1991.01810280019002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDepressive DisorderDesipramineDrug Administration ScheduleDrug Therapy, CombinationFemaleFluoxetineHospitalizationHumansMaleMiddle AgedPsychiatric Status Rating ScalesConceptsMajor depressionMean changeHamilton Depression Rating Scale scoresDepression Rating Scale scoresCombination of fluoxetineDesipramine plasma levelsRating Scale scoresBeta-adrenergic receptorsOpen studyDesipramine levelsPlasma levelsStandardized doseScale scoreDesipramineDesipramine hydrochlorideRapid treatmentPatientsFluoxetineDrugsWeeksDepressionInpatientsTreatmentRecent studiesSame setting