2022
Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder
Colic L, Clark A, Sankar A, Rathi DJ, Goldman DA, Kim JA, Villa LM, Edmiston EK, Lippard ETC, Pittman B, Constable RT, Mazure CM, Blumberg HP. Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder. European Neuropsychopharmacology 2022, 63: 35-46. PMID: 36037590, PMCID: PMC9593266, DOI: 10.1016/j.euroneuro.2022.07.186.Peer-Reviewed Original ResearchConceptsClinical featuresBipolar disorderCM severityChildhood maltreatmentLeft hippocampusPost-traumatic stress disorder (PTSD) comorbidityBrain structuresStructural magnetic resonance imagingGender-related associationMagnetic resonance imagingGray matter structuresChildhood Trauma QuestionnaireGender-related differencesCM exposureHealthy controlsClinical assessmentDisorder comorbidityMood symptomsPathophysiological modelGender-related effectsResonance imagingHippocampusFrontal poleTrauma QuestionnaireSeverity
2016
Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents
Lippard ET, Mazure CM, Johnston JA, Spencer L, Weathers J, Pittman B, Wang F, Blumberg HP. Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents. Journal Of Neuroscience Research 2016, 95: 777-791. PMID: 27870392, PMCID: PMC5123602, DOI: 10.1002/jnr.23901.Peer-Reviewed Original ResearchConceptsGray matter volumePrefrontal gray matter volumeBipolar disorderSubstance use problemsFuture substance useSubstance useLower gray matter volumeUse problemsFuture substance use problemsRegional gray matter volumeStructural magnetic resonanceAdverse outcomesTemporopolar cortexInsula gray matter volumeSubstance exposureMood disordersHigh riskLower riskSubsequent alcoholMatter volumeNeurodevelopmental basisSubstance problemsDisordersAdolescentsMales