1991
A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression
Nelson JC, Mazure CM, Bowers MB, Jatlow PI. A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression. JAMA Psychiatry 1991, 48: 303-307. PMID: 2009031, DOI: 10.1001/archpsyc.1991.01810280019002.Peer-Reviewed Original ResearchConceptsMajor depressionMean changeHamilton Depression Rating Scale scoresDepression Rating Scale scoresCombination of fluoxetineDesipramine plasma levelsRating Scale scoresBeta-adrenergic receptorsOpen studyDesipramine levelsPlasma levelsStandardized doseScale scoreDesipramineDesipramine hydrochlorideRapid treatmentPatientsFluoxetineDrugsWeeksDepressionInpatientsTreatmentRecent studiesSame setting
1988
Antidepressant activity of 2‐hydroxydesipramine
Nelson J, Mazure C, Jatlow P. Antidepressant activity of 2‐hydroxydesipramine. Clinical Pharmacology & Therapeutics 1988, 44: 283-288. PMID: 3416551, DOI: 10.1038/clpt.1988.151.Peer-Reviewed Original ResearchConceptsPlasma levelsOH-DMIAntidepressant activityDSM-III major depressionDMI levelsSteady-state plasma levelsWeeks of hospitalizationDrug plasma levelsFixed-dose protocolTotal drug levelsMajor depressionDrug levelsParent drugMeasure of responseTrialsResponsePrior studiesHospitalizationLevelsMedicationsPatientsInpatientsNonpsychoticDoseWeeks