1995
Desipramine Treatment of Major Depression in Patients Over 75 Years of Age
Nelson J, Mazure C, Jatlow P. Desipramine Treatment of Major Depression in Patients Over 75 Years of Age. Journal Of Clinical Psychopharmacology 1995, 15: 99-105.. PMID: 7782495, DOI: 10.1097/00004714-199504000-00004.Peer-Reviewed Original ResearchConceptsYounger patientsYears of ageElderly patientsMajor depressionDesipramine concentrationsDrug treatmentPatient trialsAdverse reaction rateMore effective drug treatmentsEffective drug treatmentUnipolar major depressionDesipramine treatmentDepressed patientsComparable dosesPatientsSide effectsResponse rateSimilar durationTrialsSecond trialTreatmentLower ratesBloodDepressionAge
1984
Drug-Responsive Symptoms in Melancholia
Nelson J, Mazure C, Quinlan D, Jatlow P. Drug-Responsive Symptoms in Melancholia. JAMA Psychiatry 1984, 41: 663-668. PMID: 6732425, DOI: 10.1001/archpsyc.1984.01790180033004.Peer-Reviewed Original ResearchConceptsPlasma desipramine concentrationsTricyclic antidepressant treatmentHamilton Depression ScalePretreatment symptom severityAntidepressant treatmentDesipramine treatmentDesipramine concentrationsDepression ScaleDepressive symptomsSymptomsSymptom severityDesipramine hydrochlorideDrug responseMultiple regression analysisPatientsRegression analysisTreatmentMelancholia