2022
Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder
Colic L, Clark A, Sankar A, Rathi DJ, Goldman DA, Kim JA, Villa LM, Edmiston EK, Lippard ETC, Pittman B, Constable RT, Mazure CM, Blumberg HP. Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder. European Neuropsychopharmacology 2022, 63: 35-46. PMID: 36037590, PMCID: PMC9593266, DOI: 10.1016/j.euroneuro.2022.07.186.Peer-Reviewed Original ResearchConceptsClinical featuresBipolar disorderCM severityChildhood maltreatmentLeft hippocampusPost-traumatic stress disorder (PTSD) comorbidityBrain structuresStructural magnetic resonance imagingGender-related associationMagnetic resonance imagingGray matter structuresChildhood Trauma QuestionnaireGender-related differencesCM exposureHealthy controlsClinical assessmentDisorder comorbidityMood symptomsPathophysiological modelGender-related effectsResonance imagingHippocampusFrontal poleTrauma QuestionnaireSeverity
1989
Depression in late life: age of onset as marker of a subtype
Conwell Y, Nelson J, Kim K, Mazure C. Depression in late life: age of onset as marker of a subtype. Journal Of Affective Disorders 1989, 17: 189-195. PMID: 2527894, DOI: 10.1016/0165-0327(89)90042-6.Peer-Reviewed Original ResearchConceptsAge of onsetLate-onset depressionElderly depressivesEarly-onset illnessLonger hospital stayRecurrent affective disordersDistinct pathological processesMore residual symptomsUnipolar major depressivesPresence of psychosisHospital stayClinical featuresMedical illnessResidual symptomsAffective illnessFamily historyLower incidenceMajor depressiveAffective disordersSymptom severityIllnessPathological processesDepressiveLater lifeAge