1998
Management of the Adverse Effects of Clozapine
Young CR, Bowers MB, Mazure CM. Management of the Adverse Effects of Clozapine. Schizophrenia Bulletin 1998, 24: 381-390. PMID: 9718630, DOI: 10.1093/oxfordjournals.schbul.a033333.Peer-Reviewed Original ResearchConceptsAdverse effectsElevated liver enzymesPercent of patientsSuccessful pharmacological managementPositive therapeutic outcomesHypothesized pathophysiologyPharmacological managementRefractory schizophreniaNeuromuscular effectsTraditional neurolepticsLiver enzymesPharmacological interventionsClozapineAffective disordersTherapeutic outcomesNeurological disordersMental disordersMaximum doseObsessive-compulsive symptomsWeight gainDisordersPatientsPathophysiologyNew hopeTreatment
1989
Depression in late life: age of onset as marker of a subtype
Conwell Y, Nelson J, Kim K, Mazure C. Depression in late life: age of onset as marker of a subtype. Journal Of Affective Disorders 1989, 17: 189-195. PMID: 2527894, DOI: 10.1016/0165-0327(89)90042-6.Peer-Reviewed Original ResearchConceptsAge of onsetLate-onset depressionElderly depressivesEarly-onset illnessLonger hospital stayRecurrent affective disordersDistinct pathological processesMore residual symptomsUnipolar major depressivesPresence of psychosisHospital stayClinical featuresMedical illnessResidual symptomsAffective illnessFamily historyLower incidenceMajor depressiveAffective disordersSymptom severityIllnessPathological processesDepressiveLater lifeAge