2011
Poliomyelitis in MuLV-infected ICR-SCID mice after injection of basement membrane matrix contaminated with lactate dehydrogenase-elevating virus.
Carlson Scholz JA, Garg R, Compton SR, Allore HG, Zeiss CJ, Uchio EM. Poliomyelitis in MuLV-infected ICR-SCID mice after injection of basement membrane matrix contaminated with lactate dehydrogenase-elevating virus. Comparative Medicine 2011, 61: 404-11. PMID: 22330347, PMCID: PMC3193062.Peer-Reviewed Original ResearchConceptsAge-dependent poliomyelitisClinical signsDehydrogenase-elevating virusICR-SCID miceSpinal cordRT-PCRMurine leukemia virusLife-long viremiaLactate dehydrogenase-elevating virusLeukemia virusVentral spinal cordEndogenous murine leukemia virusPCR-positive animalsLDV infectionClinical presentationAxonal degenerationICR miceVentral rootsTypical neuropathologyTransplantable tumorsInadvertent exposurePoliomyelitisBasement membrane matrixHindlimb musculaturePremonitory signs
2009
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS
Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR, Perrin S, Feany MB, Horwich AL. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 1392-1397. PMID: 19171884, PMCID: PMC2631083, DOI: 10.1073/pnas.0813045106.Peer-Reviewed Original ResearchConceptsNucleotide exchange factorsIntermediate filament proteinsAbundant cytosolic enzymeChaperone interactionsExchange factorMutant formsAmyotrophic lateral sclerosis resultsChaperone associationMotor neuronsRNA hybridizationTransgenic animalsPunctate aggregatesSuperoxide dismutase 1Filament proteinsCytosolic enzymeMisfolded monomersHuman SOD1Predominant expressionSoluble stateBiochemical analysisInsoluble inclusionsDismutase 1Immunoaffinity captureProteinTransgenic mice