2022
Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data
Mullin S, Vander Wyk B, Asher JL, Compton SR, Allore HG, Zeiss CJ. Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data. PNAS Nexus 2022, 1: pgac096. PMID: 35799833, PMCID: PMC9254158, DOI: 10.1093/pnasnexus/pgac096.Peer-Reviewed Original ResearchSARS-CoV-2 transmissionNatural infectionDuration of immunitySARS-CoV-2 pandemicAnimal model dataEndemic stateHeterologous vaccinationMedian timeCoronaviral diseaseDeterministic compartmental modelNatural immunityLow prevalenceCoronaviral infectionVaccinationViral transmissionInfectionTransmissible variantsImmunityEndemic patternReinfection dataNatural exposureReinfectionEndemic stabilityVariable durationAnimals
2014
Improving the predictive value of interventional animal models data
Zeiss CJ. Improving the predictive value of interventional animal models data. Drug Discovery Today 2014, 20: 475-482. PMID: 25448761, PMCID: PMC4417064, DOI: 10.1016/j.drudis.2014.10.015.Peer-Reviewed Original ResearchConceptsAnimal studiesSignificant potential confoundersAnimal model dataPercent of interventionsMore animal modelsPotential confoundersChronic diseasesImproved outcomesAmyloid hypothesisAnimal modelsPredictive valueAlzheimer's diseasePositive outcomesDiseaseTranslational successOutcomesPositive-outcome biasInterventionAdditional mechanismAnimalsMemantineConfoundersDonepezil