1991
Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies
Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E. Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. Blood 1991, 78: 2139-2149. DOI: 10.1182/blood.v78.8.2139.bloodjournal7882139.Peer-Reviewed Original ResearchAnti-CD5 MoAbHigh-risk patientsGraft failureHost diseaseHematologic malignanciesT cellsEpstein-Barr virus-associated lymphoproliferative disorderBone marrowActuarial event-free survivalBone marrow T lymphocytesAnti-CD5 monoclonal antibodyDiagnosis of myelodysplasiaMarrow T lymphocytesEvent-free survivalLow-risk patientsLate graft failureTotal body irradiationSignificant risk factorsRisk of relapseMajor histocompatibility complexActuarial survivalAcute graftAcute GVHDChronic GVHDEvaluable patientsSelective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies
Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E, Reichert T, Blythman H, Bouloux C, Rappeport J, Burakoff S, Weinstein H. Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies. Blood 1991, 78: 2139-2149. PMID: 1717080, DOI: 10.1182/blood.v78.8.2139.2139.Peer-Reviewed Original ResearchConceptsAnti-CD5 MoAbHigh-risk patientsGraft failureHost diseaseHematologic malignanciesT cellsEpstein-Barr virus-associated lymphoproliferative disorderBone marrowActuarial event-free survivalBone marrow T lymphocytesAnti-CD5 monoclonal antibodyDiagnosis of myelodysplasiaMarrow T lymphocytesEvent-free survivalLow-risk patientsLate graft failureTotal body irradiationSignificant risk factorsRisk of relapseMajor histocompatibility complexActuarial survivalAcute graftAcute GVHDChronic GVHDEvaluable patients
1985
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
First LR, Smith BR, Lipton J, Nathan DG, Parkman R, Rappeport JM. Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes. Blood 1985, 65: 368-74. PMID: 3881142, DOI: 10.1182/blood.v65.2.368.bloodjournal652368.Peer-Reviewed Original ResearchConceptsBone marrow transplantationMarrow transplantationThrombocytopenic syndromesChronic GVHDIsolated thrombocytopeniaPlatelet countThrombocytopenic patientsTransient thrombocytopeniaAllogeneic bone marrow transplantationSevere acute graftTrimethoprim-sulfamethoxazole administrationPeripheral platelet destructionTotal body irradiationBone marrow biopsyNormal platelet countAdverse patient prognosisNumber of megakaryocytesAcute graftIneffective thrombopoiesisPretransplant preparationHost diseasePreparatory regimensBody irradiationPlatelet destructionPlatelet precursorsIsolated Thrombocytopenia After Allogeneic Bone Marrow Transplantation: Existence of Transient and Chronic Thrombocytopenic Syndromes
First L, Smith B, Lipton J, Nathan D, Parkman R, Rappeport J. Isolated Thrombocytopenia After Allogeneic Bone Marrow Transplantation: Existence of Transient and Chronic Thrombocytopenic Syndromes. Blood 1985, 65: 368-374. DOI: 10.1182/blood.v65.2.368.368.Peer-Reviewed Original ResearchBone marrow transplantationMarrow transplantationThrombocytopenic syndromesChronic GVHDIsolated thrombocytopeniaPlatelet countThrombocytopenic patientsTransient thrombocytopeniaAllogeneic bone marrow transplantationSevere acute graftTrimethoprim-sulfamethoxazole administrationPeripheral platelet destructionTotal body irradiationBone marrow biopsyNormal platelet countAdverse patient prognosisNumber of megakaryocytesAcute graftIneffective thrombopoiesisPretransplant preparationHost diseasePreparatory regimensBody irradiationPlatelet destructionPlatelet precursors
1984
ISOLATED THROMBOCYTOPENIA FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION
First L, Smith B, Lipton J, Nathan D, Parkman R, Rappeport J. ISOLATED THROMBOCYTOPENIA FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION. Pediatric Research 1984, 18: 240-240. DOI: 10.1203/00006450-198404001-00880.Peer-Reviewed Original ResearchBone marrow transplantationMarrow transplantationManifestations of GVHDSevere acute graftTrimethoprim-sulfamethoxazole therapyDays post transplantAllogeneic bone marrowTotal body irradiationNormal platelet countAcute graftChronic GVHDHost diseasePost transplantPreparatory regimensBody irradiationIsolated thrombocytopeniaTransient syndromePlatelet countPost-TxSignificant complicationsChronic syndromeChronic thrombocytopeniaDrug therapyPatient prognosisTransient thrombocytopenia