2021
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes
Mandal P, Bhattacharjee B, Sen S, Bhattacharya A, Saha S, Chowdhury R, Mondal N, Chakrabarty B, Chatterjee T, Roy S, Sengupta S. Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes. Translational Oncology 2021, 15: 101256. PMID: 34717279, PMCID: PMC8564679, DOI: 10.1016/j.tranon.2021.101256.Peer-Reviewed Original ResearchSquamous cell carcinomaSquamous cell carcinoma casesLineage ACell carcinomaCervical squamous cell carcinomaE7 mRNA expressionHuman papillomavirus type 16Lineage A virusNon-malignant specimensAssociation of variantsDNA copy numberD lineageCytological outcomeHPV16 genomeEpisomal HPV16Sub-lineagesCopy numberIndian patientsA virusType 16Oncogenic phenotypeHPV16LineagesA1 virusesRisk alleles
2016
Complete Genome Sequences of Eight Human Papillomavirus Type 16 Asian American and European Variant Isolates from Cervical Biopsies and Lesions in Indian Women
Mandal P, Bhattacharjee B, Sen S, Bhattacharya A, Chowdhury R, Mondal N, Sengupta S. Complete Genome Sequences of Eight Human Papillomavirus Type 16 Asian American and European Variant Isolates from Cervical Biopsies and Lesions in Indian Women. Microbiology Resource Announcements 2016, 4: e00243-16. PMID: 27198009, PMCID: PMC4878291, DOI: 10.1128/genomea.00243-16.Peer-Reviewed Original ResearchComplete genome sequenceGenome sequenceHuman papillomavirus type 16Asian-American variantsVariant isolatesPapillomaviridae familyPrimary etiological agentEtiological agent of cervical cancerAgent of cervical cancerType 16Papillomavirus typePrimary etiological agent of cervical cancerEuropean variantsSequenceAmerican variantHuman papillomavirus typeVariantsPapillomaviridaeIsolatesHPV16Cervical biopsy
2012
Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions
Ghosh D, Bhattacharjee B, Sen S, Premi L, Mukhopadhyay I, Chowdhury R, Roy S, Sengupta S. Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions. PLOS ONE 2012, 7: e44678. PMID: 22970286, PMCID: PMC3435323, DOI: 10.1371/journal.pone.0044678.Peer-Reviewed Original ResearchConceptsLong control regionViral loadViral genomeReplication originsCaCx casesEpisomal HPV16 genomesLack of methylationE7 mRNA expressionHuman papillomavirus 16Binding site IGene copy numberCervical cancer pathogenesisRepressor proteinBisulphite sequencingControl regionHPV16 genomeCervical carcinogenesisHost genesGenomeCervical cancerCopy numberViral transcriptionHPV16Cancer pathogenesisOncogene E7
2010
Association of viral load with HPV16 positive cervical cancer pathogenesis: Causal relevance in isolates harboring intact viral E2 gene
Das D, Bhattacharjee B, Sen S, Mukhopadhyay I, Sengupta S. Association of viral load with HPV16 positive cervical cancer pathogenesis: Causal relevance in isolates harboring intact viral E2 gene. Virology 2010, 402: 197-202. PMID: 20394955, DOI: 10.1016/j.virol.2010.03.030.Peer-Reviewed Original ResearchConceptsViral loadE2 statusAssociation of viral loadMedian viral loadViral loads compared to controlsAge of subjectsCervical cancer pathogenesisViral E2 geneCompared to controlsCervical cancerLogistic regression modelsCancer pathogenesisTaqMan assayLower ageCaCxHPV16E2 genePathogenesisAgeIntact E2Regression modelsStatusGenomic DNAAssociationCancer
2005
HPV16 E2 gene disruption and polymorphisms of E2 and LCR: Some significant associations with cervical cancer in Indian women
Bhattacharjee B, Sengupta S. HPV16 E2 gene disruption and polymorphisms of E2 and LCR: Some significant associations with cervical cancer in Indian women. Gynecologic Oncology 2005, 100: 372-378. PMID: 16246404, DOI: 10.1016/j.ygyno.2005.09.016.Peer-Reviewed Original ResearchConceptsE2 disruptionE2 geneE2 gene disruptionIntact E2 geneIndian womenBi-directional sequencingAsian-American variantsNucleotide sequence alterationsDNA-binding regionHPV16 E2 geneCaCx developmentHPV16 isolatesCompared to controlsChi-square testCaCx casesFisher's exactCervical cancerViral factorsHPV16Nucleotide variationsE subgroupGene disruptionSequence alterationsPCR amplificationNucleotide