2015
Limits and patterns of cytomegalovirus genomic diversity in humans
Renzette N, Pokalyuk C, Gibson L, Bhattacharjee B, Schleiss M, Hamprecht K, Yamamoto A, Mussi-Pinhata M, Britt W, Jensen J, Kowalik T. Limits and patterns of cytomegalovirus genomic diversity in humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4120-e4128. PMID: 26150505, PMCID: PMC4522815, DOI: 10.1073/pnas.1501880112.Peer-Reviewed Original ResearchConceptsGenomic diversityHuman hostGenome-wide mutationsHuman cytomegalovirusRecombination rate mapsHCMV populationsViral genomic diversityGenome beingRegulatory proteinsViral populationsDiversityPolymorphismHostPatient samplesDiverse regionsGenomeNatural infectionLociCongenitally infected infantsGenesMutationsProteinInfected infantsGlycoproteinRecombination
2011
Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants
Renzette N, Bhattacharjee B, Jensen J, Gibson L, Kowalik T. Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants. PLOS Pathogens 2011, 7: e1001344. PMID: 21625576, PMCID: PMC3098220, DOI: 10.1371/journal.ppat.1001344.Peer-Reviewed Original ResearchConceptsRNA virusesReplication of RNA genomesGenome-wide variabilityPopulation genetic analysesRNA virus populationsHuman cytomegalovirusGenome wide studiesAmino acid levelsIntrahost populationsDsDNA genomeRNA genomeGenomic variabilityGenome typesPositive selectionGenetic analysisGenomeDNA virusesVirus populationsViral populationsWide studiesCongenital human cytomegalovirusImmune-mediated mechanismsCongenitally infected infantsSamples of neonatesFidelity replication