1996
Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl
Lytle C, Forbush B. Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl. American Journal Of Physiology 1996, 270: c437-c448. PMID: 8779905, DOI: 10.1152/ajpcell.1996.270.2.c437.Peer-Reviewed Original ResearchConceptsNa-K-Cl cotransporterNa-K-ClCotransport activityNa-K-Cl cotransport proteinResponse to cell shrinkageIncreased cotransport activityExtracellular K concentrationBlocking activityRefractory to forskolinPhosphatase inhibitor calyculin AInhibitor calyculin AShark rectal glandCotransporter proteinCytoplasmic Cl-CotransporterCell ClSecretory stimuliCell shrinkageCalyculin APhosphorylationRate of entryRegulatory phosphorylationPhosphorylation stateSecretory tubulesRectal gland
1992
Na-K-Cl cotransport in the shark rectal gland. II. Regulation in isolated tubules
Lytle C, Forbush B. Na-K-Cl cotransport in the shark rectal gland. II. Regulation in isolated tubules. American Journal Of Physiology 1992, 262: c1009-c1017. PMID: 1314482, DOI: 10.1152/ajpcell.1992.262.4.c1009.Peer-Reviewed Original ResearchConceptsNa-K-Cl cotransporterNa-K-ClShark rectal glandInhibitor of Na-K-Cl cotransportApical Cl- channelsCell shrinkageEffects of secretagoguesOsmotically induced changesSensitivity to cAMPCl- channelsExtracellular sodiumIsolated tubulesCotransporterHormonal modulationSecretory stimuliSignal transduction pathwaysSecretagoguesRectal glandTubulesRectal gland secretionHypertonicityCell volumeTransduction pathwaysGlandCells