Evaluation of Next-Generation Anti-CD20 Antibodies Labeled with 89Zr in Human Lymphoma Xenografts
Yoon JT, Longtine MS, Marquez-Nostra BV, Wahl RL. Evaluation of Next-Generation Anti-CD20 Antibodies Labeled with 89Zr in Human Lymphoma Xenografts. Journal Of Nuclear Medicine 2018, 59: 1219-1224. PMID: 29348316, PMCID: PMC6071500, DOI: 10.2967/jnumed.117.203299.Peer-Reviewed Original ResearchConceptsTumor uptakeCD20 antibodyLymphoma xenograftsMonoclonal antibodiesDrug AdministrationBurkitt's lymphoma xenograftsHigher splenic uptakeAnti-CD20 antibodyCD20 monoclonal antibodyPET/CT imagingHuman lymphoma xenograftsSmall-animal PET/CT imagesPreclinical mouse modelsB-cell lymphomaPET/CTPET/CT imagesHigh tumor uptakeNext-Generation AntiClear tumor uptakePalpable tumorsSplenic uptakeImmunodeficient miceEffective treatmentMouse modelObinutuzumab