2019
Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes
Franca A, Filho A, Guerra MT, Weerachayaphorn J, dos Santos M, Njei B, Robert M, Lima C, Vidigal P, Banales JM, Ananthanarayanan M, Leite MF, Nathanson MH. Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes. Hepatology 2019, 69: 817-830. PMID: 30141207, PMCID: PMC6351171, DOI: 10.1002/hep.30228.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Alcoholic hepatitisEffect of endotoxinBile duct cellsNF-κBInhibition of TLR4Human cholangiocytesStimulation of TLR4Duct cellsSevere alcoholic hepatitisCholestasis of sepsisForms of cholestasisNF-κB subunitsP65/p50Trisphosphate receptorReceptor 4Clinical conditionsBicarbonate secretionHepatocellular changesITPR3 expressionCholestasisType 3 inositolLPS receptorAgonist stimulusSepsis
2016
Corticosteroids Versus Pentoxifylline for Severe Alcoholic Hepatitis
Njei B, Do A, McCarty TR, Fortune BE. Corticosteroids Versus Pentoxifylline for Severe Alcoholic Hepatitis. Journal Of Clinical Gastroenterology 2016, 50: 871-881. PMID: 27404293, PMCID: PMC5065367, DOI: 10.1097/mcg.0000000000000585.Peer-Reviewed Original ResearchConceptsSevere alcoholic hepatitisAlcoholic hepatitisTrial sequential analysisShort-term mortalityHepatorenal syndromeStudies satisfied inclusion criteriaEffect of corticosteroidsSatisfied inclusion criteriaMortality benefitSignificant morbidityCochrane CollaborationEpidemiologic evidenceCochrane LibraryInclusion criteriaCorticosteroidsHepatitisIndependent reviewersTherapeutic strategiesThird investigatorPentoxifyllinePublication statusPlaceboComprehensive searchMortalityInitial reviewers