2023
Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial
Morais A, Locascio J, Sansing L, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig J, Bosetti F, Lyden P, Ayata C, Bosetti F, Koenig J, Lyden P, Lamb J, Nagarkatti K, Hess D, Kamat P, Khan M, Dhandapani K, Arbab A, Siddiqui S, Smith C, Nisar M, Leira E, Chauhan A, Dhanesha N, Patel R, Kumskova M, Thedens D, Wang K, Ayata C, Morais A, Imai T, Qin T, Jin X, Erdogan T, Yu L, Mandeville J, Kimberly W, Whittier J, Lo E, Arai K, Van Leyen K, Sansing L, Hyder F, Mihailovic J, Sanganahalli B, Diaz-Perez S, Velazquez S, Beatty H, Johnson C, Herman A, Boisserand L, Immakavar E, Koehler R, Dawson T, Dawson V, Shi Y, Avery B, Lannon S, Bibic A, Akhter K, Karuppagounder S, Aronowski J, McCullough L, Obertas L, Goh A, Huang S, Chauhan A. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke 2023, 54: 620-631. PMID: 36601951, PMCID: PMC9870939, DOI: 10.1161/strokeaha.122.040638.Peer-Reviewed Original ResearchConceptsTotal anesthesia durationAnesthesia durationIndependent predictorsMultivariable analysisClinical trialsTransient focal cerebral ischemiaFocal cerebral ischemiaCerebral blood flowLaser Doppler flowCentralized randomizationModified intentionTreat populationExperimental strokeCerebral ischemiaDoppler flowRodent modelsMCAOBlood flowNetwork trialFlow dropPreclinical trialsMouse cohortsStudy designTrialsTrial onset
2020
APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease
Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiology Of Disease 2020, 139: 104834. PMID: 32173556, PMCID: PMC7486698, DOI: 10.1016/j.nbd.2020.104834.Peer-Reviewed Original ResearchConceptsCerebral blood flowAsymptomatic APOE4 carriersE4FAD miceAPOE4 carriersAlzheimer's diseaseCerebrovascular reactivityNeurotransmitter levelsE3FAD micePharmacogenetic responsePharmacogenetic differencesSomatosensory responsesBlood-brain barrier functionBrain functionStrongest genetic risk factorBrain metabolic changesFree fatty acid levelsAmyloid-beta plaquesHuman APOE4 geneDifferent APOE allelesAPOE ε3 alleleFuture clinical testingGenetic risk factorsFatty acid levelsWhite matter integrityAβ transport
2013
Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability
Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 1115-1126. PMID: 23591650, PMCID: PMC3705442, DOI: 10.1038/jcbfm.2013.61.Peer-Reviewed Original ResearchConceptsSensory-evoked cortical activityCentral nervous system metabolismCerebral blood flowCortical neuronal activityStimulus-evoked responsesCentral nervous systemBlood oxygen level dependenceNeocortical excitabilityBrain signalingHemodynamic responseBlood flowNeuronal activityNervous systemCortical activityNeocortical activityCalcium changesExtracellular electrophysiologyMCU activityMCU inhibitorVivo impactVivo mitochondriaDependent mannerMultiple subcellular compartmentsRole of mitochondriaUniporter activity
2011
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingBrain WavesCerebral CortexCerebrovascular CirculationCorpus StriatumDisease Models, AnimalElectroencephalographyElectrophysiologyEpilepsyImage Processing, Computer-AssistedLaser-Doppler FlowmetryMagnetic Resonance ImagingNicotinic AntagonistsOxygenRatsRats, WistarThalamusTubocurarineVibrissaeConceptsCerebral blood flowCerebral blood volumeLocal field potentialsNeuronal activityLaser Doppler cerebral blood flowSubcortical structuresWAG/Rij ratsNeuronal activity decreasesHuman absence epilepsySpike-wave dischargesWAG/RijMultiunit activity recordingsFMRI signalsFunctional magnetic resonance imaging (fMRI) signalsMagnetic resonance imaging signalsFMRI decreasesCBF decreaseHemodynamic changesCerebral cortexBasal gangliaSomatosensory cortexAbsence epilepsyWhisker stimulationBlood flowAnimal models
2010
Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms
Hyder F, Sanganahalli BG, Herman P, Coman D, Maandag NJ, Behar KL, Blumenfeld H, Rothman DL. Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms. Frontiers In Neuroenergetics 2010, 2: 18. PMID: 20838476, PMCID: PMC2936934, DOI: 10.3389/fnene.2010.00018.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingCerebral blood flowMulti-unit activityLocal field potentialsNeurometabolic couplingQuantitative functional magnetic resonance imagingBOLD signalCerebral metabolic rateNeural activityBlood oxygenation level-dependent (BOLD) contrastMagnetic resonance imagingMapping brain activityLevel-dependent contrastBlood flowMUA recordingsNeurophysiological parametersAnimal studiesResonance imagingBrain functionTissue poolsEvent-related paradigmField potentialsBrain activityNeural activity recordingActivity recordings
2007
Negative BOLD with Large Increases in Neuronal Activity
Schridde U, Khubchandani M, Motelow JE, Sanganahalli BG, Hyder F, Blumenfeld H. Negative BOLD with Large Increases in Neuronal Activity. Cerebral Cortex 2007, 18: 1814-1827. PMID: 18063563, PMCID: PMC2790390, DOI: 10.1093/cercor/bhm208.Peer-Reviewed Original ResearchConceptsCerebral blood flowCerebral blood volumeFunctional magnetic resonance imagingNegative BOLD signalsNeuronal activityBOLD signalLevel-dependent functional magnetic resonance imagingBlood oxygen level-dependent functional magnetic resonance imagingBOLD functional magnetic resonance imagingCerebral metabolic ratePositive BOLD signalMagnetic resonance imagingBlood flowNegative BOLDBlood volumeResonance imagingBrain regionsPathological conditionsNeuronal recordingsBrain activityFMRI signalsOxygen consumptionMetabolic rateMetabolic activitySeizures