2024
Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies
Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, Hwa J, Bona R. Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies. Blood Cells Molecules And Diseases 2024, 110: 102893. PMID: 39260211, DOI: 10.1016/j.bcmd.2024.102893.Peer-Reviewed Original ResearchInherited platelet disordersClinically significant bleedingCases of patientsHeterogeneous group of conditionsGroup of conditionsSignificant bleedingDiagnostic yieldDiagnostic dilemmaPlatelet disordersBleeding disordersEvaluating patientsPatient cohortMolecular pathogenesisMass cytometryHeterogeneous groupPatientsMultimodal approachBleedingImprove patient careDiagnosisDisordersPatient careGenetic sequencesLaboratory testing approachPotential utilityCost-effectiveness of rapid vs in-house vs send-out ADAMTS13 testing for immune thrombotic thrombocytopenic purpura
Allen C, Ito S, Butt A, Purcell A, Richmond R, Tormey C, Krumholz H, Cuker A, Goshua G. Cost-effectiveness of rapid vs in-house vs send-out ADAMTS13 testing for immune thrombotic thrombocytopenic purpura. Blood Advances 2024, 8: 2279-2289. PMID: 38502197, PMCID: PMC11116991, DOI: 10.1182/bloodadvances.2024012608.Peer-Reviewed Original ResearchImmune thrombotic thrombocytopenic purpuraPLASMIC scoreThrombotic thrombocytopenic purpuraThrombocytopenic purpuraADAMTS13 testingIncremental net monetary benefitPer-patient cost savingsTherapeutic plasma exchangeBase-case analysisMarkov cohort simulationProbabilistic sensitivity analysesAmount of QALYEmpirical therapyADAMTS13 assaysPlasma exchangeEmpirical treatmentCaplacizumabFRET-based assayPrimary outcomePatientsNet monetary benefitCohort simulationCost-effectiveness evaluationPurpuraTesting strategies
2022
COVID-19 and antiphospholipid antibodies
Butt A, Erkan D, Lee A. COVID-19 and antiphospholipid antibodies. Best Practice & Research Clinical Haematology 2022, 35: 101402. PMID: 36494152, PMCID: PMC9568270, DOI: 10.1016/j.beha.2022.101402.Peer-Reviewed Original ResearchConceptsAntiphospholipid antibodiesCOVID-19 patientsAntiphospholipid syndromeCOVID-19Antiphospholipid antibody productionCOVID-19 coagulopathyCOVID-19 shareMechanism of thrombogenesisCOVID-19 vaccinationNeutrophil extracellular trapsActivation of plateletsPathophysiologic featuresClinical outcomesExtracellular trapsSuch antibodiesAntibody productionComplement pathwayPatientsSyndromeAntibodiesConflicting resultsCoagulopathyImmunothrombosisHypercoagulabilityVaccinationAssociation of iron infusion reactions with ABO blood type
Butt A, Muradashvili T, Soliman S, Li F, Burns AJ, Brooks A, Browning S, Bar N, Borgman G, Goshua G, Hwa J, Martin K, Rinder H, Tormey C, Pine AB, Bona RD, Lee AI, Neparidze N. Association of iron infusion reactions with ABO blood type. European Journal Of Haematology 2022, 109: 519-525. PMID: 35871468, DOI: 10.1111/ejh.13838.Peer-Reviewed Original ResearchConceptsGreater oddsBlood typeYale Cancer CenterInfusion-related reactionsRetrospective chart reviewLarger patient numbersABO blood typeType AB bloodChart reviewInfusion reactionsMost patientsHematology clinicIron sucroseMultivariable analysisProspective studyCancer CenterPatient numbersIron dextranRisk factorsIron infusionIron repletionPatientsPossible associationAB bloodBlood
2020
Idiopathic pulmonary hemosiderosis - A rare cause of chronic anemia
Butt A, Ahmed R, Sheikh MDA, Khan O, Iqbal N, Rahman AJ, Khan JA. Idiopathic pulmonary hemosiderosis - A rare cause of chronic anemia. Monaldi Archives For Chest Disease 2020, 90 PMID: 32512987, DOI: 10.4081/monaldi.2020.1267.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary hemosiderosisDiffuse alveolar hemorrhageChronic anemiaPulmonary hemosiderosisLung biopsyCases of IPHCauses of DAHDiagnosis of IPHReversible encephalopathy syndromeAccumulation of hemosiderinAlveolar bleedingEncephalopathy syndromeAlveolar hemorrhageRare causeSevere anemiaPatient's conditionRare diseaseAnemiaPatientsAzathioprinePrednisoloneHemosiderosisGood responseBiopsyFirst caseAnomalous origin of the left coronary artery from the pulmonary artery: A surgical certainty.
Butt A, Amanullah MM, Amanullah MA, Hasan A, Ahmad W. Anomalous origin of the left coronary artery from the pulmonary artery: A surgical certainty. Journal Of The Pakistan Medical Association 2020, 70: 561-564. PMID: 32207452, DOI: 10.5455/jpma.34200.Peer-Reviewed Original ResearchConceptsLeft coronary arteryAnomalous originPulmonary arteryCoronary arterySurgical correctionAga Khan University HospitalMain presenting featuresPre-operative medianVentricular ejection fractionALCAPA surgeryCoronary reimplantationPresenting featuresEjection fractionClinical presentationLV EFRetrospective reviewMitral regurgitationUniversity HospitalPoor feedingFavorable outcomeMortality ratePatientsArteryMild MRRegurgitation
2019
Cystic echinococcosis: a 10-year experience from a middle-income country
Butt A, Khan JA. Cystic echinococcosis: a 10-year experience from a middle-income country. Tropical Doctor 2019, 50: 117-121. PMID: 31805832, DOI: 10.1177/0049475519891338.Peer-Reviewed Original ResearchConceptsMedical therapyCystic echinococcosisAga Khan HospitalPulmonary hydatid cystsNon-specific presentationReview of chartsAbdominal painHydatid diseaseMiddle-income countriesHepatic cystsHydatid cystHigh indexPatientsTropical diseasesTherapyDiseaseCystsPresentationPainReaspirationSurgeryFeverRecurrenceHospitalEchinococcosis