Featured Publications
Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension
Phillips RA, Xu J, Peterson LE, Arnold RM, Diamond JA, Schussheim AE. Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension. Journal Of The American College Of Cardiology 2018, 71: 1601-1610. PMID: 29525494, DOI: 10.1016/j.jacc.2018.01.074.Peer-Reviewed Original ResearchConceptsSignificant serious adverse eventsPrimary outcome eventIntensive treatment groupCVD riskOutcome eventsHarm ratioIntensive treatmentTreatment groupsTreatment guidelinesAmerican CollegeCardiology/American Heart AssociationFuture cardiovascular disease riskCox proportional hazards modelBaseline CVD riskQuartiles of baselineSerious adverse eventsBlood pressure treatmentCardiovascular disease riskAmerican Heart AssociationProportional hazards modelLower ratesSPRINT populationAdverse eventsCardiovascular riskPrimary outcomePatient management after noninvasive cardiac imaging results from SPARC (Study of myocardial perfusion and coronary anatomy imaging roles in coronary artery disease).
Hachamovitch R, Nutter B, Hlatky MA, Shaw LJ, Ridner ML, Dorbala S, Beanlands RS, Chow BJ, Branscomb E, Chareonthaitawee P, Weigold WG, Voros S, Abbara S, Yasuda T, Jacobs JE, Lesser J, Berman DS, Thomson LE, Raman S, Heller GV, Schussheim A, Brunken R, Williams KA, Farkas S, Delbeke D, Schoepf UJ, Reichek N, Rabinowitz S, Sigman SR, Patterson R, Corn CR, White R, Kazerooni E, Corbett J, Bokhari S, Machac J, Guarneri E, Borges-Neto S, Millstine JW, Caldwell J, Arrighi J, Hoffmann U, Budoff M, Lima J, Johnson JR, Johnson B, Gaber M, Williams JA, Foster C, Hainer J, Di Carli MF. Patient management after noninvasive cardiac imaging results from SPARC (Study of myocardial perfusion and coronary anatomy imaging roles in coronary artery disease). Journal Of The American College Of Cardiology 2012, 59: 462-74. PMID: 22281249, DOI: 10.1016/j.jacc.2011.09.066.Peer-Reviewed Original Research
2024
CARDIAC MASS IN RIGHT ATRIUM: IMPORTANCE OF EVALUATION WITH CARDIAC MAGNETIC RESONANCE IMAGING
Jeyashanmugaraja G, Marrinan G, Schussheim A. CARDIAC MASS IN RIGHT ATRIUM: IMPORTANCE OF EVALUATION WITH CARDIAC MAGNETIC RESONANCE IMAGING. Journal Of The American College Of Cardiology 2024, 83: 1545. DOI: 10.1016/s0735-1097(24)03535-6.Peer-Reviewed Original ResearchKiosk 3Q-TA-04 Cardiac Mass in Right Atrium: Importance of Evaluation with Cardiac Magnetic Resonance Imaging
Jeyashanmugaraja G, Marrinan G, Huber S, Schussheim A. Kiosk 3Q-TA-04 Cardiac Mass in Right Atrium: Importance of Evaluation with Cardiac Magnetic Resonance Imaging. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100494. DOI: 10.1016/j.jocmr.2024.100494.Peer-Reviewed Original Research
2022
Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination
Pareek M, Steele J, Asnes J, Baldassarre L, Casale L, Desai N, Elder R, Faherty E, Ferguson I, Fishman R, Ghazizadeh Z, Glick L, Hall E, Khera R, Kokkinidis D, Kwan J, O'Marr J, Schussheim A, Tuohy E, Wang Y, Spatz E, Jacoby D, Miller E. Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination. JACC Cardiovascular Imaging 2022, 15: 2002-2005. PMID: 36357140, PMCID: PMC9094612, DOI: 10.1016/j.jcmg.2022.03.026.Peer-Reviewed Case Reports and Technical Notes
2021
Another Nudge to Overcome the Treatment-Risk Paradox in Blood Pressure Management ∗
Diamond J, Schussheim A, Phillips R. Another Nudge to Overcome the Treatment-Risk Paradox in Blood Pressure Management ∗. Journal Of The American College Of Cardiology 2021, 77: 1991-1993. DOI: 10.1016/j.jacc.2021.03.230.Peer-Reviewed Original Research
2019
FLOATING LEFT ATRIAL MASS IN A PATIENT WITH PROSTHETIC MITRAL VALVE: MANAGEMENT DILEMMA
Jeyashanmugaraja G, Mahmut A, Clarke J, Roy T, Schussheim A. FLOATING LEFT ATRIAL MASS IN A PATIENT WITH PROSTHETIC MITRAL VALVE: MANAGEMENT DILEMMA. Journal Of The American College Of Cardiology 2019, 73: 2356. DOI: 10.1016/s0735-1097(19)32962-6.Peer-Reviewed Original Research
2017
Dabigatran-Induced Spontaneous Hemopericardium and Cardiac Tamponade.
Jelani QU, Gordon R, Schussheim A. Dabigatran-Induced Spontaneous Hemopericardium and Cardiac Tamponade. Texas Heart Institute Journal / From The Texas Heart Institute Of St. Luke's Episcopal Hospital, Texas Children's Hospital 2017, 44: 370-372. PMID: 29259514, PMCID: PMC5731597, DOI: 10.14503/THIJ-16-6073.Peer-Reviewed Original Research
2011
Dipyridamole-Associated Shock and Pulmonary Edema
Dioverti M, Fishman R, Moskowitz R, Arias SA, Nair S, Lall P, Schussheim AE, Zarich S, Manthous C. Dipyridamole-Associated Shock and Pulmonary Edema. Annals Of Pharmacotherapy 2011, 45: 1027-1027. PMID: 21672887, DOI: 10.1345/aph.1p734.Peer-Reviewed Original ResearchConceptsNoncardiogenic pulmonary edemaDipyridamole myocardial scintigraphyPulmonary edemaSevere pulmonary edemaCardiopulmonary collapseMyocardial scintigraphyNew left ventricular dysfunctionPositive end-expiratory pressureObjective causality assessmentLeft ventricular dysfunctionEnd-expiratory pressureMechanism of shockFulminant shockInvasive ventilationMultiple vasopressorsCardiovascular collapseHypovolemic shockShock refractoryCase seriesDipyridamole infusionEchocardiography resultsEndotracheal intubationIntravenous dipyridamoleContinuous infusionIntravenous infusionDipyridamole-Associated Refractory Shock And Pulmonary Edema
Prono M, Fishman R, Moskowitz R, arias S, Nair S, Lall P, Schussheim A, Zarich S, Manthous C. Dipyridamole-Associated Refractory Shock And Pulmonary Edema. 2011, a3879-a3879. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3879.Peer-Reviewed Original Research
2008
24.05: Impaired contractile reserve in obese subjects: A rubidium pet study
Jain H, Driesman A, Zarich S, Brag K, Mahajan A, Meizlish J, Schussheim A. 24.05: Impaired contractile reserve in obese subjects: A rubidium pet study. Journal Of Nuclear Cardiology 2008, 15: s26. DOI: 10.1016/j.nuclcard.2008.06.147.Peer-Reviewed Original Research
2003
Contribution of mitochondria to cardiac muscle water/macromolecule proton magnetization transfer
Ward K, Schussheim A, Balaban R. Contribution of mitochondria to cardiac muscle water/macromolecule proton magnetization transfer. Magnetic Resonance In Medicine 2003, 50: 1312-1316. PMID: 14648581, DOI: 10.1002/mrm.10625.Peer-Reviewed Original ResearchDetecting Acute Coronary Syndrome in the Emergency Department With Cardiac Magnetic Resonance Imaging
Kwong RY, Schussheim AE, Rekhraj S, Aletras AH, Geller N, Davis J, Christian TF, Balaban RS, Arai AE. Detecting Acute Coronary Syndrome in the Emergency Department With Cardiac Magnetic Resonance Imaging. Circulation 2003, 107: 531-537. PMID: 12566362, DOI: 10.1161/01.cir.0000047527.11221.29.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAngina, UnstableChest PainCoronary DiseaseDiagnosis, DifferentialElectrocardiographyEmergency Service, HospitalFemaleFollow-Up StudiesHumansLikelihood FunctionsLogistic ModelsMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsProspective StudiesROC CurveSensitivity and SpecificityTroponinConceptsAcute coronary syndromeStrict ECG criteriaTIMI risk scoreCoronary syndromeChest painEmergency departmentPeak troponinAbnormal ECGRisk scoreECG criteriaProbable acute coronary syndromeCardiac MRIMultivariate logistic regression analysisCardiac magnetic resonance imagingDiagnostic operating characteristicsHours of presentationTriage of patientsAcute myocardial infarctionLogistic regression analysisCurrent diagnostic strategiesMagnetic resonance imagingUnstable anginaConsecutive patientsVentricular functionClinical parameters
2001
Left ventricular midwall function improves with antihypertensive therapy and regression of left ventricular hypertrophy in patients with asymptomatic hypertension
Schussheim A, Diamond J, Phillips R. Left ventricular midwall function improves with antihypertensive therapy and regression of left ventricular hypertrophy in patients with asymptomatic hypertension. The American Journal Of Cardiology 2001, 87: 61-65. PMID: 11137835, DOI: 10.1016/s0002-9149(00)01273-x.Peer-Reviewed Original ResearchConceptsMidwall fractional shorteningLV mass regressionAntihypertensive therapyAsymptomatic hypertensionVentricular hypertrophyMidwall functionMass regressionEarly hypertensive heart diseaseConventional echocardiographic parametersHypertensive heart diseaseLeft ventricular massPotential beneficial effectsEchocardiographic parametersFractional shorteningHypertensive personsIndependent predictorsVentricular massDrug therapyMyocardial performanceHeart diseaseCardiac performanceVentricular geometryChamber functionPatientsTherapy
1999
Antibiotics for Myocardial Infarction?
Schussheim A, Fuster V. Antibiotics for Myocardial Infarction? Drugs 1999, 57: 283-291. PMID: 10193683, DOI: 10.2165/00003495-199957030-00002.Peer-Reviewed Original ResearchConceptsInfectious organismsAtherosclerotic lesionsFuture large-scale clinical trialsLarge-scale clinical trialsRecent pilot trialRecurrent coronary eventsCoronary artery diseaseElaboration of cytokinesEvidence of infectionVascular smooth muscle cellsCoronary artery plaquesRisk of restenosisSmooth muscle cellsDirect local effectsActive atherosclerosisCoronary eventsCoronary interventionInflammatory mechanismsArtery diseaseHypercoagulable statePathological examinationAtherosclerotic processSeroepidemiological investigationCoronary endotheliumArtery plaques
1998
Midwall fractional shortening is an independent predictor of left ventricular diastolic dysfunction in asymptomatic patients with systemic hypertension
Schussheim A, Diamond J, Jhang J, Phillips R. Midwall fractional shortening is an independent predictor of left ventricular diastolic dysfunction in asymptomatic patients with systemic hypertension. The American Journal Of Cardiology 1998, 82: 1056-1059. PMID: 9817481, DOI: 10.1016/s0002-9149(98)00558-x.Peer-Reviewed Original ResearchConceptsMidwall fractional shorteningAbnormal diastolic functionMidwall shorteningHypertensive patientsSystolic functionDiastolic functionFractional shorteningDiastolic dysfunctionBlood pressureIndependent predictorsSystolic performanceEndocardial shorteningFiber shorteningLeft ventricular systolic performanceDepressed midwall shorteningHealthy hypertensive patientsLV diastolic abnormalitiesLV inflow velocityNormal midwall shorteningTarget organ damageVentricular diastolic dysfunctionIsovolumic relaxation timeLV systolic functionHigh blood pressureVentricular systolic performanceAntithrombotic therapy and venous graft disease.
Schussheim AE, Fuster V. Antithrombotic therapy and venous graft disease. Current Opinion In Cardiology 1998, 13: 459. PMID: 9822880, DOI: 10.1097/00001573-199811000-00012.Peer-Reviewed Original ResearchConceptsVenous graft diseaseGraft diseaseLow-dose oral anticoagulationAggressive cholesterol reductionEfficacy of antithromboticsCoronary artery bypassSymptom-free survivalTiming of therapyPotent antithrombotic agentOral anticoagulationAntithrombotic therapyArtery bypassGraft occlusionPreventive therapyAntiplatelet agentsHemostatic factorsAntithrombotic agentsCholesterol reductionTherapyFirst dayPatientsSurgeryDisease developmentDiseaseFirst yearIs digoxin a designer oestrogen?
Schussheim D, Schussheim A. Is digoxin a designer oestrogen? The Lancet 1998, 351: 1734. PMID: 9734913, DOI: 10.1016/s0140-6736(05)77771-0.Peer-Reviewed Original ResearchK001: Depressed midwall fractional shortening predicts diastolic dysfunction in asymptomatic hypertensive patients
Schussheim A, Diamond J, Jhang J, Phillips R. K001: Depressed midwall fractional shortening predicts diastolic dysfunction in asymptomatic hypertensive patients. American Journal Of Hypertension 1998, 11: 183a-183a. DOI: 10.1016/s0895-7061(97)91382-0.Peer-Reviewed Original ResearchRegulation of Cardiac Myocyte Contractile Function by Inducible Nitric Oxide Synthase (iNOS): Mechanisms of Contractile Depression by Nitric Oxide
Joe E, Schussheim A, Longrois D, Mäki T, Kelly R, Smith T, Balligand J. Regulation of Cardiac Myocyte Contractile Function by Inducible Nitric Oxide Synthase (iNOS): Mechanisms of Contractile Depression by Nitric Oxide. Journal Of Molecular And Cellular Cardiology 1998, 30: 303-315. PMID: 9515007, DOI: 10.1006/jmcc.1997.0593.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthineAcetylcysteineAdenylyl CyclasesAdrenergic beta-AgonistsAnimalsCulture Media, ConditionedCyclic AMPCyclic GMPEnzyme InductionGTP-Binding ProteinsIn Vitro TechniquesIsoproterenolLipopolysaccharidesMacrophages, AlveolarMyocardial ContractionNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIPhosphodiesterase InhibitorsRatsRats, Sprague-DawleyConceptsInducible nitric oxide synthaseInduction of iNOSBeta-adrenergic stimulationMacrophage-conditioned mediumNM IsoCardiac myocytesContractile responseContractile functionBeta-adrenergic receptor densityNitric oxideMyocyte contractile functionSystemic immune stimulationCardiac contractile functionNitric oxide synthaseCardiac myocyte contractile functionRat lung macrophagesAdenylyl cyclase activityCultured ventricular myocytesContractile depressionNOS inhibitionAdrenergic responsivenessInflammatory cytokinesElevation of cAMPCardiac functionNOS inhibitor