2021
Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome
Radhakrishna U, Vishweswaraiah S, Uppala LV, Szymanska M, Macknis J, Kumar S, Saleem-Rasheed F, Aydas B, Forray A, Muvvala SB, Mishra NK, Guda C, Carey DJ, Metpally RP, Crist RC, Berrettini WH, Bahado-Singh RO. Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome. Genomics 2021, 113: 1127-1135. PMID: 33711455, DOI: 10.1016/j.ygeno.2021.03.006.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeIngenuity Pathway AnalysisWithdrawal syndromeOpioid-exposed pregnanciesPlacental tissue samplesOpioid abusePlacental tissueTissue samplesPregnancyMethylation dysregulationGenome-wide methylation analysisSyndromeInfantsPathway analysisAUCDNA methylation profilesMethylation profilesGroupPathophysiologyTherapyStrong evidence
2016
Substance use during pregnancy
Forray A. Substance use during pregnancy. F1000Research 2016, 5: f1000 faculty rev-887. PMID: 27239283, PMCID: PMC4870985, DOI: 10.12688/f1000research.7645.1.Peer-Reviewed Original ResearchPrenatal substance useSubstance useCurrent therapeutic optionsPublic health concernCritical public health concernFetal outcomesFetal consequencesPsychiatric comorbidityTherapeutic optionsPrenatal useFetal healthPsychosocial interventionsPolysubstance usePregnancyExisting treatmentsHealth concernIllicit substancesContingency managementCannabisComorbiditiesOpioidsTobaccoRecent literatureCare
2015
Substance Use in the Perinatal Period
Forray A, Foster D. Substance Use in the Perinatal Period. Current Psychiatry Reports 2015, 17: 91. PMID: 26386836, PMCID: PMC4671272, DOI: 10.1007/s11920-015-0626-5.Peer-Reviewed Original ResearchConceptsPerinatal substance usePerinatal periodSubstance useMajor public health problemPublic health problemUse of tobaccoFetal outcomesFetal effectsFetal healthCurrent treatmentPsychosocial interventionsPolysubstance useHealth problemsNovel interventionsMost efficacyCocaine useIllicit substancesContingency managementPregnancyInterventionTreatmentOpioidsTobaccoProgesteroneRecent literaturePerinatal substance use: A prospective evaluation of abstinence and relapse
Forray A, Merry B, Lin H, Ruger JP, Yonkers KA. Perinatal substance use: A prospective evaluation of abstinence and relapse. Drug And Alcohol Dependence 2015, 150: 147-155. PMID: 25772437, PMCID: PMC4387084, DOI: 10.1016/j.drugalcdep.2015.02.027.Peer-Reviewed Original ResearchConceptsRates of abstinenceMean daysSubstance useMultivariate Cox modelLittle prospective dataPostpartum relapseRelapse postpartumAbstinence ratesProspective evaluationNicotine cigarettesProspective dataCox modelPregnancyRelapseCigarettesAbstinenceToxicology testingCocaineWomenPsychological treatmentLast monthPostpartumMarijuanaSpecific substancesDays
2013
Perinatal smoking and depression in women with concurrent substance use
Forray A, Gotman N, Kershaw T, Yonkers KA. Perinatal smoking and depression in women with concurrent substance use. Addictive Behaviors 2013, 39: 749-756. PMID: 24447885, PMCID: PMC3944019, DOI: 10.1016/j.addbeh.2013.12.008.Peer-Reviewed Original ResearchConceptsPregnant womenConcurrent substance useSubstance usePre-pregnancy smokersSignificant depressive symptomsWeeks of pregnancyMini Neuropsychiatric InterviewDiagnosis of depressionImpact of depressionCourse of smokingNon-depressed groupLinear mixed effects regressionSubstance abuse treatmentPerinatal smokingSmoking postpartumBaseline cohortNeuropsychiatric InterviewMixed effects regressionDepressive symptomsSmokingSmoking behaviorDepressive symptomatologyAbuse treatmentPregnancyPostpartumAntidepressant Use in Pregnant and Postpartum Women
Yonkers KA, Blackwell KA, Glover J, Forray A. Antidepressant Use in Pregnant and Postpartum Women. Annual Review Of Clinical Psychology 2013, 10: 369-392. PMID: 24313569, PMCID: PMC4138492, DOI: 10.1146/annurev-clinpsy-032813-153626.Peer-Reviewed Original ResearchConceptsAntidepressant usePersistent pulmonary hypertensionAdverse birth outcomesNeonatal complicationsShortened gestationPulmonary hypertensionAntidepressant exposureBirth outcomesPregnant womenPostpartum womenFetal growthMajor teratogensReproductive yearsLate pregnancyNeonatal signsCardiac malformationsAntidepressantsPregnancyAnxiety disordersAdverse effectsInconclusive evidenceWomenInconsistent literatureMalformationsRisk
2010
Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period.
Forray A, Focseneanu M, Pittman B, McDougle CJ, Epperson CN. Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period. The Journal Of Clinical Psychiatry 2010, 71: 1061-8. PMID: 20492843, PMCID: PMC4204467, DOI: 10.4088/jcp.09m05381blu.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultAge of OnsetAgedComorbidityDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMenarcheMiddle AgedObsessive-Compulsive DisorderParturitionPregnancyPregnancy ComplicationsPremenstrual SyndromePsychiatric Status Rating ScalesPuerperal DisordersReproductive HistoryRetrospective StudiesSeverity of Illness IndexConceptsOnset of OCDObsessive-compulsive disorderOCD onsetPregnant groupPerinatal periodOCD symptomsWorsening of symptomsExacerbation of symptomsImpact of pregnancyDSM-IV disordersStructured Clinical InterviewDSM-IV criteriaStudent's t-testPremenstrual worseningTotal pregnanciesSymptom exacerbationPostpartum periodExacerbationPregnancyClinical InterviewOCD clinicReproductive life cycleSymptom severitySymptomsCategorical variables