2018
Phase 1 study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreoretinal lymphoma
Tun HW, Johnston PB, DeAngelis LM, Atherton PJ, Pederson LD, Koenig PA, Reeder CB, Omuro AMP, Schiff D, O'Neill B, Pulido J, Jaeckle KA, Grommes C, Witzig TE. Phase 1 study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreoretinal lymphoma. Blood 2018, 132: 2240-2248. PMID: 30262659, PMCID: PMC6265643, DOI: 10.1182/blood-2018-02-835496.Peer-Reviewed Original ResearchConceptsPrimary central nervous system lymphomaOverall response ratePrimary vitreoretinal lymphomaProgression-free survivalRefractory primary central nervous system lymphomaComplete responsePartial responseVitreoretinal lymphomaGrade 3/4 hematologic toxicitiesGrade 3/4 nonhematologic toxicitiesMedian progression-free survivalCentral nervous system lymphomaDose escalation schedulePhase 1 studyNervous system lymphomaCombination of pomalidomideSignificant therapeutic activityMTD cohortNonhematologic toxicityHematologic toxicityRespiratory failureSystem lymphomaMTD determinationPrimary CNSSafety profile
2008
Primary CNS lymphoma with intraocular involvement
Grimm S, McCannel C, Omuro A, Ferreri A, Blay J, Neuwelt E, Siegal T, Batchelor T, Jahnke K, Shenkier T, Hall A, Graus F, Herrlinger U, Schiff D, Raizer J, Rubenstein J, Laperriere N, Thiel E, Doolittle N, Iwamoto F, Abrey L. Primary CNS lymphoma with intraocular involvement. Neurology 2008, 71: 1355-1360. PMID: 18936428, PMCID: PMC4109164, DOI: 10.1212/01.wnl.0000327672.04729.8c.Peer-Reviewed Original ResearchConceptsPrimary CNS lymphomaOverall survivalOcular therapyIntraocular involvementCNS lymphomaCSF cytologyMedian Eastern Cooperative Oncology Group performance statusEastern Cooperative Oncology Group performance statusMedian progression-free survivalClinical ophthalmic examinationLocal ocular therapyCommon presenting symptomProgression-free survivalSite of progressionDiagnosis of lymphomaEyes 12Primary CNSFree survivalIntraocular lymphomaPresenting symptomBrain lymphomaImmunocompetent patientsOcular involvementPerformance statusRetinal biopsy