T cell dysfunction in glioblastoma: a barrier and an opportunity for the development of successful immunotherapies
Jansen JA, Omuro A, Lucca LE. T cell dysfunction in glioblastoma: a barrier and an opportunity for the development of successful immunotherapies. Current Opinion In Neurology 2021, 34: 827-833. PMID: 34569985, PMCID: PMC8595795, DOI: 10.1097/wco.0000000000000988.Peer-Reviewed Original ResearchConceptsT cell dysfunctionTumor-infiltrating T cellsT cellsCell dysfunctionFuture immunotherapy strategiesCervical lymph nodesTumor-derived antigensImmune checkpoint blockadeCentral nervous systemHomeostatic brainSuccessful immunotherapyCheckpoint blockadeImmunotherapy strategiesLymph nodesTumor rejectionImmune surveillanceImmune responseMouse modelBrain tumorsLymphatic drainageNervous systemSolid tumorsDysfunctionSingle-cell RNA sequencingNatural history