2021
Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool
Shaw JE, Kilander MBC, Lin YC, Koleske AJ. Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool. Journal Of Neuroscience 2021, 41: 3068-3081. PMID: 33622779, PMCID: PMC8026353, DOI: 10.1523/jneurosci.2472-20.2021.Peer-Reviewed Original ResearchConceptsDendritic spine stabilityDendritic spinesSpine stabilityTonic increaseSubset of spinesSexes of miceMost excitatory synapsesCortactin interactionsGluN2B levelsSpine densitySpine lossArg nonreceptor tyrosine kinaseKinetically distinct poolsExcitatory synapsesHippocampal neuronsSynaptic activitySpine enlargementSpineSpine sizeSpine actinActivity-dependent spine enlargementSpine shapeStructural plasticityDistinct poolsTyrosine kinase
2020
ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice
Wang F, Hou W, Chitsike L, Xu Y, Bettler C, Perera A, Bank T, Cotler SJ, Dhanarajan A, Denning MF, Ding X, Breslin P, Qiang W, Li J, Koleske AJ, Qiu W. ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. Gastroenterology 2020, 159: 289-305.e16. PMID: 32171747, PMCID: PMC7387191, DOI: 10.1053/j.gastro.2020.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularCell Line, TumorDatasets as TopicDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansKaplan-Meier EstimateLiverLiver NeoplasmsMaleMicePhosphorylationPrognosisProto-Oncogene MasProto-Oncogene Proteins c-ablProto-Oncogene Proteins c-mycPyrimidinesReceptor, Notch1Xenograft Model Antitumor AssaysConceptsShorter survival timeLiver tumorsExpression of Notch1Hepatocellular carcinomaHuman HCC cellsHCC cellsXenograft tumorsSurvival timeExpression of MYCLiver tissueTreatment of HCCAlbumin-Cre miceNon-tumor liver tissuesABL proto-oncogene 1Nontumor liver tissuesHuman HCC specimensHuh7 HCC cellsHepatocyte-specific disruptionHCC tissue microarrayProto-oncogene 1HCC cell linesShort hairpin RNACancer Genome AtlasKnockdown of Notch1Tumor levels
2019
Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits
Katrancha SM, Shaw JE, Zhao AY, Myers SA, Cocco AR, Jeng AT, Zhu M, Pittenger C, Greer CA, Carr SA, Xiao X, Koleske AJ. Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits. Cell Reports 2019, 26: 2805-2817.e9. PMID: 30840899, PMCID: PMC6436967, DOI: 10.1016/j.celrep.2019.02.022.Peer-Reviewed Original ResearchConceptsHeterozygous coding mutationsDendritic spine densityHippocampus of miceNeurodevelopmental disordersLong-term potentiationDendritic spine defectsPostsynaptic deficitsSpine densityCortical synapsesDendritic arborizationExcitatory neuronsMotor coordinationHaploinsufficient miceKnockout miceTherapeutic interventionsBipolar disorderProtein kinase A (PKA) signalingNeuronal structuresSpine defectsIncreases anxietyMiceDisordersDeficitsCoding mutationsA Signaling
2017
The vascular endothelial specific IL-4 receptor alpha–ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions
Yamani A, Wu D, Waggoner L, Noah T, Koleske AJ, Finkelman F, Hogan SP. The vascular endothelial specific IL-4 receptor alpha–ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions. Journal Of Allergy And Clinical Immunology 2017, 142: 1159-1172.e5. PMID: 29157947, PMCID: PMC5957775, DOI: 10.1016/j.jaci.2017.08.046.Peer-Reviewed Original ResearchConceptsIgE-mediated anaphylactic reactionsAnaphylactic reactionsFluid extravasationIL-4RαBarrier dysfunctionIL-4Food-induced anaphylactic reactionsIgE-induced anaphylaxisFood-induced anaphylaxisIgE-mediated anaphylaxisIL-4 receptor α chainIgE-mediated reactionsTreatment of miceSevere anaphylactic reactionsSeverity of anaphylaxisABL kinase inhibitor imatinibKinase inhibitor imatinibReceptor α chainVe cell linesVenous vasodilatationOral antigenHypovolemic shockInhibitor imatinibAnaphylaxisVe cellsBrain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity
Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE. Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity. ACS Chemical Neuroscience 2017, 8: 1554-1569. PMID: 28418645, PMCID: PMC5517348, DOI: 10.1021/acschemneuro.7b00076.Peer-Reviewed Original ResearchConceptsLong-term potentiationCalpain sensitivityEffects of cocaineRat nucleus accumbensAdult rat nucleus accumbensRho GDP/GTP exchange factorRegion-specific effectsChronic cocaineNucleus accumbensSynaptic functionBrain regionsKALRN geneSpine morphologyPrefrontal cortexKal7CocainePotentiationFunctional significanceCalpainPhosphorylation
2016
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development
Shapiro LP, Parsons RG, Koleske AJ, Gourley SL. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. Journal Of Neuroscience Research 2016, 95: 1123-1143. PMID: 27735056, PMCID: PMC5352542, DOI: 10.1002/jnr.23960.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnalysis of VarianceAnimalsBrain-Derived Neurotrophic FactorCytoskeletonDendritic SpinesFemaleGene Expression Regulation, DevelopmentalHumansIntegrin beta1MaleMembrane GlycoproteinsMiceMice, TransgenicNeural PathwaysNeuronsPrefrontal CortexReceptor, trkBSignal TransductionSynapsesSynaptophysinConceptsPrefrontal cortexDendritic spinesTropomyosin-related kinase receptor BDifferent adolescent agesKinase receptor BPrevalence of depressionMental health disordersDeep-layer excitatory neuronsRho kinase 2TrkB levelsVentral hippocampusOrbital prefrontal cortexAge-related differencesPsychiatric illnessReceptor BExcitatory neuronsPostnatal brainHealth disordersAnatomical connectionsNeuronal structuresWestern blottingAdolescent ageEarly adulthoodDramatic structural reorganizationPFC subregionsDisruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice
Xiao X, Levy AD, Rosenberg BJ, Higley MJ, Koleske AJ. Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice. Journal Of Neuroscience 2016, 36: 6778-6791. PMID: 27335408, PMCID: PMC4916252, DOI: 10.1523/jneurosci.4092-15.2016.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornDendritic SpinesExcitatory Amino Acid AgentsFemaleGene Expression Regulation, DevelopmentalGlutamic AcidHippocampusHSP70 Heat-Shock ProteinsIn Vitro TechniquesMaleMiceMice, Inbred C57BLMice, KnockoutNeuronal PlasticityNeurotransmitter AgentsProtein-Tyrosine KinasesReceptors, GlutamateReceptors, N-Methyl-D-AspartateSubcellular FractionsSynapsesSynaptic PotentialsConceptsNMDA receptorsHippocampal synapsesEarly adulthoodFocal glutamate uncagingImmature glutamatergic synapsesDendritic spine numberNormal synaptic plasticityPostnatal day 21NMDA receptor currentsLate postnatal developmentHigh release probabilityArg kinaseForms of plasticityGlutamate uncagingSynapse lossPresynaptic sitesGlutamatergic synapsesSynapse stabilityPostsynaptic sitesSynaptic stabilityCultured neuronsMice ageReceptor currentsDay 21Synaptic plasticity
2013
Integrin α3 Is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior
Kerrisk ME, Greer CA, Koleske AJ. Integrin α3 Is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior. Journal Of Neuroscience 2013, 33: 6742-6752. PMID: 23595732, PMCID: PMC3711182, DOI: 10.1523/jneurosci.0528-13.2013.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlpha-FetoproteinsAnalysis of VarianceAnimalsAnimals, NewbornBasic Helix-Loop-Helix Transcription FactorsCell MembraneDendritesDendritic SpinesDisks Large Homolog 4 ProteinFemaleGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsGuanylate KinasesHippocampusImmunoprecipitationIntegrin alpha3LysineMaleMembrane ProteinsMemory DisordersMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalNerve Tissue ProteinsNeuronsPhosphopyruvate HydrataseRecognition, PsychologyRhoA GTP-Binding ProteinSynapsesConceptsDendritic spinesIntegrin α3Adult rodent forebrainHippocampal-dependent behaviorsPostnatal day 21Excitatory forebrain neuronsMouse behaviorProper hippocampal functionLong-term potentiationArbor stabilityArg nonreceptor tyrosine kinaseRodent forebrainForebrain neuronsSynapse densitySynapse stabilityDendrite arborsDay 21Arbor sizeHippocampal dendritesHippocampal functionMutant miceSynapse maintenanceBrain functionNeurodegenerative diseasesKey mediatorDelayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice
Couch BA, Kerrisk ME, Kaufman AC, Nygaard HB, Strittmatter SM, Koleske AJ. Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice. The Journal Of Comparative Neurology 2013, 521: 1395-1408. PMID: 23047754, PMCID: PMC3562562, DOI: 10.1002/cne.23239.Peer-Reviewed Original ResearchConceptsAβPP/PS1 micePS1 micePlaque burdenPlaque depositionBehavioral deficitsRadial arm water maze performanceBehavioral impairmentsAlzheimer's diseaseAβPP processingPresenilin 1Amyloid-β precursor proteinLower plaque burdenProgressive neurodegenerative dementiaAmyloid plaque depositionAmyloid plaque accumulationAmyloid plaque burdenAD-like featuresNovel object recognitionWater maze performanceMonths of ageDendrite lossAD progressionNeurodegenerative dementiaPlaque accumulationMixed genetic backgroundCorticosteroid-Induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience
Gourley SL, Swanson AM, Koleske AJ. Corticosteroid-Induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience. Journal Of Neuroscience 2013, 33: 3107-3112. PMID: 23407965, PMCID: PMC3711631, DOI: 10.1523/jneurosci.2138-12.2013.Peer-Reviewed Original ResearchConceptsStressor exposureDendritic spinesDendritic spine densityRecovery periodCA1 pyramidal neuronsHippocampal CA1 neuronsCertain neuron populationsStress hormone exposureStress-related modificationsDistinct brain regionsBehavioral vulnerabilityDendritic retractionPyramidal neuronsCA1 neuronsNeural remodelingSpine densityStress-related diseasesHippocampal CA1Orbital cortexBasal amygdalaDendritic arborsHormone exposureNeuron populationsBrain regionsBrain circuitsAbl2/Arg Controls Dendritic Spine and Dendrite Arbor Stability via Distinct Cytoskeletal Control Pathways
Lin YC, Yeckel MF, Koleske AJ. Abl2/Arg Controls Dendritic Spine and Dendrite Arbor Stability via Distinct Cytoskeletal Control Pathways. Journal Of Neuroscience 2013, 33: 1846-1857. PMID: 23365224, PMCID: PMC3711664, DOI: 10.1523/jneurosci.4284-12.2013.Peer-Reviewed Original Research
2012
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, DiLeone RJ, Koleske AJ, Taylor JR. Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 20714-20719. PMID: 23185000, PMCID: PMC3528547, DOI: 10.1073/pnas.1208342109.Peer-Reviewed Original ResearchMeSH KeywordsAffectAmitriptylineAnimalsAntidepressive Agents, TricyclicBehavior, AnimalBrain-Derived Neurotrophic FactorConditioning, PsychologicalCorticosteroneDendritic SpinesGene Knockdown TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMifepristoneMotivationPrefrontal CortexRatsRats, Sprague-DawleyReceptors, GlucocorticoidStress, PhysiologicalConceptsGlucocorticoid receptorStress-related mood disordersStressor exposureAdrenal axis feedbackRole of BDNFGlucocorticoid receptor bindingChronic stressor exposureProgressive ratio taskGR blockadeBDNF expressionBDNF knockdownNeurotrophin systemSpine remodelingMood disordersChronic exposureBDNFGR bindingReceptor bindingResponse-outcome learningFood reinforcementAxis feedbackRU38486CorticosteroneStimulus-response associationsMotivational deficitsIntegrin β1 Signals through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior
Warren MS, Bradley WD, Gourley SL, Lin YC, Simpson MA, Reichardt LF, Greer CA, Taylor JR, Koleske AJ. Integrin β1 Signals through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior. Journal Of Neuroscience 2012, 32: 2824-2834. PMID: 22357865, PMCID: PMC3313657, DOI: 10.1523/jneurosci.3942-11.2012.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-FetoproteinsAnalysis of VarianceAnimalsAnimals, NewbornAvoidance LearningBasic Helix-Loop-Helix Transcription FactorsCells, CulturedCocaineDendritesEnzyme-Linked Immunosorbent AssayExploratory BehaviorGreen Fluorescent ProteinsGTPase-Activating ProteinsHippocampusImmunoprecipitationIntegrin beta1MaleMiceMice, KnockoutMutationNerve Tissue ProteinsNeuronsOrgan Culture TechniquesPost-Synaptic DensityProtein BindingRecognition, PsychologyRepressor ProteinsSignal TransductionSrc Homology DomainsSynapsesConceptsIntegrin β1Vertebrate nervous systemExtracellular matrix receptorsGenetic experimentsIntracellular tailGenetic manipulationRhoA GTPaseArg kinaseMatrix receptorsProper hippocampal functionProper developmentSynapse maintenanceDose-sensitive mannerImpaired hippocampus-dependent learningHippocampal dendritic arborsHippocampal synapse lossDendritic arbor sizeHippocampus-dependent learningΒ1ArgSelective lossGTPaseP190RhoGAPPsychomotor sensitivityKinaseArg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity
Gourley SL, Olevska A, Warren MS, Taylor JR, Koleske AJ. Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity. Journal Of Neuroscience 2012, 32: 2314-2323. PMID: 22396406, PMCID: PMC3386297, DOI: 10.1523/jneurosci.2730-11.2012.Peer-Reviewed Original ResearchConceptsSpine densityAdolescent wild-type mouseHippocampal CA1 pyramidal neuronsDendritic spine densityCA1 pyramidal neuronsPostnatal day 60Wild-type miceDendritic spine developmentCocaine-Induced PlasticityAddictive-like behaviorsPyramidal neuronsCocaine sensitizationDendritic spinesPsychomotor sensitizationProtective consequencesSpine headsNeuropsychiatric disordersOrbitofrontal cortexDay 60Local applicationArg inhibitionPsychomotor sensitivityIntracellular mechanismsPsychostimulant sensitivitySpine development
2011
ErbB4 Localization to Interneurons: Clearer Insights into Schizophrenia Pathology
Cooper MA, Koleske AJ. ErbB4 Localization to Interneurons: Clearer Insights into Schizophrenia Pathology. Biological Psychiatry 2011, 70: 602-603. PMID: 21924131, PMCID: PMC3376398, DOI: 10.1016/j.biopsych.2011.08.002.Peer-Reviewed Original Research
2010
Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation
de Arce K, Varela-Nallar L, Farias O, Cifuentes A, Bull P, Couch BA, Koleske AJ, Inestrosa NC, Alvarez AR. Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation. Journal Of Neuroscience 2010, 30: 3728-3738. PMID: 20220006, PMCID: PMC2872795, DOI: 10.1523/jneurosci.2024-09.2010.Peer-Reviewed Original ResearchConceptsPSD-95Protein postsynaptic density protein 95Postsynaptic density protein 95PSD-95 clusteringHippocampal neuron culturesFirst postnatal weekC-AblC-Abl levelsPresynaptic markersTyrosine phosphorylationRat hippocampusPostnatal weekPostsynaptic sitesSynaptic clusteringNeuron culturesSynaptic functionC-Abl kinase activityReduced synapsesSynapse formationPostsynaptic compartmentsBrain synapsesGenetic inhibitionSynapsesTyrosine kinaseC-Abl tyrosine kinase
2007
Inhibition of Rho via Arg and p190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior
Sfakianos MK, Eisman A, Gourley SL, Bradley WD, Scheetz AJ, Settleman J, Taylor JR, Greer CA, Williamson A, Koleske AJ. Inhibition of Rho via Arg and p190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior. Journal Of Neuroscience 2007, 27: 10982-10992. PMID: 17928439, PMCID: PMC6672862, DOI: 10.1523/jneurosci.0793-07.2007.Peer-Reviewed Original ResearchConceptsDendritic spine maturationDendritic regressionSpine maturationDendritic spinesNormal morphological maturationDendritic spine lossPostnatal day 21Late postnatal developmentPostnatal mouse hippocampusDendrite stabilityPyramidal dendritesSpine lossSynaptic refinementProgressive deficitsHippocampal synapsesMature neuronsArbor developmentInhibitory pathwaysMouse hippocampusDendrite arborsDay 21Postnatal developmentMorphological maturationDendritic branchesDendrite morphogenesis
1998
Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation
Koleske A, Gifford A, Scott M, Nee M, Bronson R, Miczek K, Baltimore D. Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation. Neuron 1998, 21: 1259-1272. PMID: 9883720, DOI: 10.1016/s0896-6273(00)80646-7.Peer-Reviewed Original Research
1993
Quantitative Comparison of Initiation and Mutation Phenotypes in Hepatocytes of the Analbuminemic Rat
Dragan Y, Laufer C, Koleske A, Drinkwater N, Pilot H. Quantitative Comparison of Initiation and Mutation Phenotypes in Hepatocytes of the Analbuminemic Rat. Cancer Science 1993, 84: 175-183. PMID: 8463134, PMCID: PMC5919122, DOI: 10.1111/j.1349-7006.1993.tb02852.x.Peer-Reviewed Original Research
1989
Phenobarbital-inducible Aldehyde Dehydrogenase in the Rat cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats
Dunn TJ, Koleske AJ, Lindahl R, Pitot HC. Phenobarbital-inducible Aldehyde Dehydrogenase in the Rat cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats. Journal Of Biological Chemistry 1989, 264: 13057-13065. PMID: 2753900, DOI: 10.1016/s0021-9258(18)51595-7.Peer-Reviewed Original ResearchConceptsComplete nucleotide sequenceSpecific gene expressionAldehyde dehydrogenaseAmino acid sequenceGlutathione S-transferase YaRat cDNA sequenceStrong conservationCDNA sequenceNucleotide sequenceMRNA speciesAcid sequenceGene expressionCytosolic isozymeMolecular massAmino acidsCytochrome P-450eMultiple pathwaysMRNAResponsive allelesMRNA levelsSequenceRegulationCytochrome P-450bDehydrogenaseP-450e