2017
Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase
Shapiro LP, Omar MH, Koleske AJ, Gourley SL. Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Molecular And Cellular Neuroscience 2017, 85: 226-234. PMID: 29107098, PMCID: PMC5767942, DOI: 10.1016/j.mcn.2017.10.007.Peer-Reviewed Original ResearchConceptsCorticosterone exposureHippocampal CA1 pyramidal neuronsStressor exposureArbor structureCA1 pyramidal neuronsAnhedonic-like behaviorClassical neurotransmitter systemsSpecific brain regionsMental health concernsDendrite lossPyramidal neuronsStress-related illnessesArg nonreceptor tyrosine kinaseNeuronal remodelingNeurotransmitter systemsNeural degenerationBehavioral abnormalitiesTrigger pointsCognitive declineBrain regionsKey next stepHealth concernKey mediatorMental healthPharmacological compounds
2015
Direct Interactions with the Integrin β1 Cytoplasmic Tail Activate the Abl2/Arg Kinase*
Simpson MA, Bradley WD, Harburger D, Parsons M, Calderwood DA, Koleske AJ. Direct Interactions with the Integrin β1 Cytoplasmic Tail Activate the Abl2/Arg Kinase*. Journal Of Biological Chemistry 2015, 290: 8360-8372. PMID: 25694433, PMCID: PMC4375489, DOI: 10.1074/jbc.m115.638874.Peer-Reviewed Original ResearchConceptsIntegrin β1 cytoplasmic tailExtracellular matrix adhesion receptorsSrc homology domainFibroblast cell motilityIntegrin β1Β1 cytoplasmic tailMembrane-proximal segmentAdhesion complex formationMatrix adhesion receptorsNonreceptor tyrosine kinaseArg kinase activityArg nonreceptor tyrosine kinaseCancer cell invasivenessHomology domainActin cytoskeletonCytoplasmic tailCytoskeletal remodelingDendrite morphogenesisTyr-783Kinase domainPhosphorylated regionAbl familyΒ1 tailArg kinaseCell motility
2011
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
Chung C, Mader CC, Schmitz J, Atladottir J, Fitchev P, Cornwell M, Koleske AJ, Crawford SE, Gorelick F. The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer. Laboratory Investigation 2011, 91: 732-743. PMID: 21339745, PMCID: PMC3084324, DOI: 10.1038/labinvest.2011.8.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaMMP-9 activityHuman pancreatic cancerPancreatic cancerPanIN lesionsHigh-grade PanIN lesionsHuman pancreatic ductal adenocarcinomaPancreatic intraepithelial neoplasmsCancer cellsLow-grade PanIN lesionsMatrix metalloproteinase activationMMP-2 activityPancreatic cancer cellsHuman cancer tissuesShort hairpin RNAPancreatic histologyIntraepithelial neoplasmDuctal adenocarcinomaNormal ductsMMP releaseCancer tissuesMMP-2Metalloproteinase activationInvasive propertiesSpecific MMPs
2004
Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor
Plattner R, Koleske AJ, Kazlauskas A, Pendergast AM. Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor. Molecular And Cellular Biology 2004, 24: 2573-2583. PMID: 14993293, PMCID: PMC355852, DOI: 10.1128/mcb.24.6.2573-2583.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineChemotaxisEnzyme ActivationIn Vitro TechniquesMacromolecular SubstancesMiceNIH 3T3 CellsPhospholipase C gammaPhosphorylationProtein-Tyrosine KinasesProto-Oncogene Proteins c-ablReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor betaRecombinant ProteinsSignal TransductionType C PhospholipasesConceptsPDGF beta receptorPlatelet-derived growth factorC-AblPLC-gamma1C-Abl nonreceptor tyrosine kinaseTyrosine kinaseGrowth factor signalsSrc family kinasesC-Abl functionNonreceptor tyrosine kinaseTyrosine kinase activityPlatelet-derived growth factor receptorAbundant phosphoinositideMembrane rufflingInducible complexNonredundant functionsFamily kinasesMembrane proteinsC-gamma1Factor signalsGrowth factor receptorAbelson kinaseKinase activityBiological processesChemotaxis defect
2003
Two Distinct Phosphorylation Pathways Have Additive Effects on Abl Family Kinase Activation
Tanis KQ, Veach D, Duewel HS, Bornmann WG, Koleske AJ. Two Distinct Phosphorylation Pathways Have Additive Effects on Abl Family Kinase Activation. Molecular And Cellular Biology 2003, 23: 3884-3896. PMID: 12748290, PMCID: PMC155218, DOI: 10.1128/mcb.23.11.3884-3896.2003.Peer-Reviewed Original ResearchConceptsSrc nonreceptor tyrosine kinaseAdditive effectTyrosine kinaseArg nonreceptor tyrosine kinaseKinase activationNonreceptor tyrosine kinaseKinase activityCell surface receptorsSurface receptorsStimuli resultsStimulationFivefold stimulationActivationTwofold stimulationABLPhosphorylationPhosphorylation pathwayPathwaySrc family kinase HckSrc family
1994
An RNA polymerase II holoenzyme responsive to activators
Koleske A, Young R. An RNA polymerase II holoenzyme responsive to activators. Nature 1994, 368: 466-469. PMID: 8133894, DOI: 10.1038/368466a0.Peer-Reviewed Original ResearchConceptsRNA polymerase IIGeneral transcription factorsRNA polymerase II holoenzymePolymerase IITranscription factorsPromoter DNAMulti-component complexesGAL4-VP16Initiation factorsRegulatory proteinsHoloenzymeProteinDNAOrdered fashionCerevisiaeTranscriptionVivoPromoterActivatorAssemblyEquimolar amountsComplexes