2017
Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity
Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE. Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity. ACS Chemical Neuroscience 2017, 8: 1554-1569. PMID: 28418645, PMCID: PMC5517348, DOI: 10.1021/acschemneuro.7b00076.Peer-Reviewed Original ResearchConceptsLong-term potentiationCalpain sensitivityEffects of cocaineRat nucleus accumbensAdult rat nucleus accumbensRho GDP/GTP exchange factorRegion-specific effectsChronic cocaineNucleus accumbensSynaptic functionBrain regionsKALRN geneSpine morphologyPrefrontal cortexKal7CocainePotentiationFunctional significanceCalpainPhosphorylation
2016
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development
Shapiro LP, Parsons RG, Koleske AJ, Gourley SL. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. Journal Of Neuroscience Research 2016, 95: 1123-1143. PMID: 27735056, PMCID: PMC5352542, DOI: 10.1002/jnr.23960.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnalysis of VarianceAnimalsBrain-Derived Neurotrophic FactorCytoskeletonDendritic SpinesFemaleGene Expression Regulation, DevelopmentalHumansIntegrin beta1MaleMembrane GlycoproteinsMiceMice, TransgenicNeural PathwaysNeuronsPrefrontal CortexReceptor, trkBSignal TransductionSynapsesSynaptophysinConceptsPrefrontal cortexDendritic spinesTropomyosin-related kinase receptor BDifferent adolescent agesKinase receptor BPrevalence of depressionMental health disordersDeep-layer excitatory neuronsRho kinase 2TrkB levelsVentral hippocampusOrbital prefrontal cortexAge-related differencesPsychiatric illnessReceptor BExcitatory neuronsPostnatal brainHealth disordersAnatomical connectionsNeuronal structuresWestern blottingAdolescent ageEarly adulthoodDramatic structural reorganizationPFC subregions
2014
Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex
Cooper MA, Koleske AJ. Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex. The Journal Of Comparative Neurology 2014, 522: 3351-3362. PMID: 24752666, PMCID: PMC4107058, DOI: 10.1002/cne.23615.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell FractionationCells, CulturedDendritic SpinesDisks Large Homolog 4 ProteinGene Expression RegulationGreen Fluorescent ProteinsGuanylate KinasesMembrane ProteinsMiceMice, TransgenicMitogen-Activated Protein Kinase 3NestinNeuronsPrefrontal CortexReceptor, ErbB-4SynapsesTransfectionConceptsDendritic spine densitySpine densityExcitatory pyramidal cellsExcitatory neuronsPrefrontal cortexPyramidal cellsDendritic spinesErbB4 functionAblation of ErbB4Dendritic spine lossCortical neuronal culturesMouse prefrontal cortexDendritic spine developmentMonths of ageSynaptic plasma membrane preparationsSpine lossWeanling miceDorsomedial prefrontal cortexPsychiatric disordersKnockout miceMature spinesErbB4 signalingSynaptic plasticityNeuronal culturesDisease pathology