2014
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors
DePoy LM, Perszyk RE, Zimmermann KS, Koleske AJ, Gourley SL. Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors. Frontiers In Pharmacology 2014, 5: 228. PMID: 25452728, PMCID: PMC4233985, DOI: 10.3389/fphar.2014.00228.Peer-Reviewed Original ResearchDendritic arborsCocaine exposureDendritic spinesPre-existing structural abnormalitiesAdolescent cocaine exposurePostnatal day 31Prior cocaine exposureCocaine-induced modificationsDrugs of abuseDosing protocolDrug-naïveDrug exposureLocomotor activationExcitatory neuronsLong-term effectsAnimal modelsDay 31Structural abnormalitiesOrbitofrontal cortexBehavioral effectsBrain structuresMiceNeurobehavioral phenotypesCocaine vulnerabilityCell populations
2012
Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity
Gourley SL, Olevska A, Warren MS, Taylor JR, Koleske AJ. Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity. Journal Of Neuroscience 2012, 32: 2314-2323. PMID: 22396406, PMCID: PMC3386297, DOI: 10.1523/jneurosci.2730-11.2012.Peer-Reviewed Original ResearchConceptsSpine densityAdolescent wild-type mouseHippocampal CA1 pyramidal neuronsDendritic spine densityCA1 pyramidal neuronsPostnatal day 60Wild-type miceDendritic spine developmentCocaine-Induced PlasticityAddictive-like behaviorsPyramidal neuronsCocaine sensitizationDendritic spinesPsychomotor sensitizationProtective consequencesSpine headsNeuropsychiatric disordersOrbitofrontal cortexDay 60Local applicationArg inhibitionPsychomotor sensitivityIntracellular mechanismsPsychostimulant sensitivitySpine development