1995
The RNA polymerase II holoenzyme and its implications for gene regulation
Koleske A, Young R. The RNA polymerase II holoenzyme and its implications for gene regulation. Trends In Biochemical Sciences 1995, 20: 113-116. PMID: 7709429, DOI: 10.1016/s0968-0004(00)88977-x.Peer-Reviewed Original ResearchConceptsRNA polymerase II holoenzymeTranscription initiation apparatusGeneral transcription factorsRNA polymerase holoenzymeGene regulationPol IIPolymerase holoenzymeTranscriptional regulatorsTranscription factorsB proteinGene expressionLarge complexesSRB componentsHoloenzymeRegulationRecent evidenceComplexesSuppressorRegulatorProteinExpression
1992
A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID
Koleske A, Buratowski S, Nonet M, Young R. A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID. Cell 1992, 69: 883-894. PMID: 1591782, DOI: 10.1016/0092-8674(92)90298-q.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceBlotting, WesternChromatography, AffinityFungal ProteinsGenes, SuppressorMediator ComplexMolecular Sequence DataMutationRecombinant Fusion ProteinsRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription Factor TFIIDTranscription FactorsTranscription, GeneticConceptsCarboxy-terminal domainRNA polymerase II carboxy-terminal domainNovel transcription factorTranscription initiation complexInitiation complexTranscription factorsFunctional linkConditional growth phenotypesTranscription initiation apparatusRNA polymerase IITATA-binding factorDominant suppressorsPolymerase IIGrowth phenotypeTranscription initiationGene expressionAllele specificitySRB2Truncation mutationsSame functionSimilar defectsTFIIDSuppressorEfficient establishmentMechanism of action
1989
Phenobarbital-inducible Aldehyde Dehydrogenase in the Rat cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats
Dunn TJ, Koleske AJ, Lindahl R, Pitot HC. Phenobarbital-inducible Aldehyde Dehydrogenase in the Rat cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats. Journal Of Biological Chemistry 1989, 264: 13057-13065. PMID: 2753900, DOI: 10.1016/s0021-9258(18)51595-7.Peer-Reviewed Original ResearchConceptsComplete nucleotide sequenceSpecific gene expressionAldehyde dehydrogenaseAmino acid sequenceGlutathione S-transferase YaRat cDNA sequenceStrong conservationCDNA sequenceNucleotide sequenceMRNA speciesAcid sequenceGene expressionCytosolic isozymeMolecular massAmino acidsCytochrome P-450eMultiple pathwaysMRNAResponsive allelesMRNA levelsSequenceRegulationCytochrome P-450bDehydrogenaseP-450e