2014
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors
DePoy LM, Perszyk RE, Zimmermann KS, Koleske AJ, Gourley SL. Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors. Frontiers In Pharmacology 2014, 5: 228. PMID: 25452728, PMCID: PMC4233985, DOI: 10.3389/fphar.2014.00228.Peer-Reviewed Original ResearchDendritic arborsCocaine exposureDendritic spinesPre-existing structural abnormalitiesAdolescent cocaine exposurePostnatal day 31Prior cocaine exposureCocaine-induced modificationsDrugs of abuseDosing protocolDrug-naïveDrug exposureLocomotor activationExcitatory neuronsLong-term effectsAnimal modelsDay 31Structural abnormalitiesOrbitofrontal cortexBehavioral effectsBrain structuresMiceNeurobehavioral phenotypesCocaine vulnerabilityCell populations
2011
Cell adhesion signaling pathways: First responders to cocaine exposure?
Gourley SL, Taylor JR, Koleske AJ. Cell adhesion signaling pathways: First responders to cocaine exposure? Communicative & Integrative Biology 2011, 4: 30-3. PMID: 21509173, PMCID: PMC3073265, DOI: 10.4161/cib.4.1.14083.Peer-Reviewed Original ResearchCocaine exposureDendritic spinesDendritic spine structureChronic drug exposureCertain brain regionsExpression/functionDrug exposurePsychomotor sensitizationPsychostimulant exposureBrain regionsFirst respondersNeuronal shapeSpine structureHuman brainRespondersExposureSpineTyrosine kinaseRecent findingsNonreceptor tyrosine kinaseCell adhesion receptorsAdhesion receptorsDevelopmental periodAdhesion factorsCell adhesion factorsCell adhesion signaling pathways
Gourley S, Taylor J, Koleske A. Cell adhesion signaling pathways. Communicative & Integrative Biology 2011, 4: 30-33. DOI: 10.4161/cib.14083.Peer-Reviewed Original ResearchDendritic spinesDendritic spine structureChronic drug exposureCertain brain regionsExpression/functionDrug exposureCocaine exposurePsychomotor sensitizationPsychostimulant exposureBrain regionsNeuronal shapeSpine structureHuman brainExposureSpineTyrosine kinaseRecent findingsNonreceptor tyrosine kinaseCell adhesion receptorsAdhesion receptorsDevelopmental periodAdhesion factorsCell adhesion factorsFirst respondersCytoskeletal effectors
2009
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
Gourley SL, Koleske AJ, Taylor JR. Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 16859-16864. PMID: 19805386, PMCID: PMC2742404, DOI: 10.1073/pnas.0902286106.Peer-Reviewed Original ResearchConceptsDopamine D2 receptor levelsLocomotor depressant actionsD2 receptor levelsWild-type micePsychomotor stimulant actionDendritic simplificationAntagonist haloperidolStimulant actionCocaine exposureCortical axonsDendritic arborsReceptor levelsCocaine administrationSynaptic pruningDendrite stabilizationNeuropsychiatric disordersArg inhibitionMiceNormal sensitivityDendritic refinementCytoskeletal stabilizationCocaineAdolescenceReversal taskRhoA GTPase