2020
Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy.
Young CR, Kulon ME, Boustani AM, Pucar D. Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy. Clinical Nuclear Medicine 2020, 46: e179-e180. PMID: 33086270, DOI: 10.1097/rlu.0000000000003340.Peer-Reviewed Original ResearchConceptsPET/CTAltered biodistributionMediastinal T-cell lymphoblastic lymphomaPosttreatment FDG PET/CTFDG PET/CTT-cell lymphoblastic lymphomaSubcutaneous white adipose tissueWhite adipose tissueTreatment response assessmentSubcutaneous white fatAsparaginase chemotherapyLymphoblastic lymphomaAsparaginase resistanceFDG biodistributionResponse assessmentWhite fatGlucose metabolismAdipose tissueTreatment cyclesLeukemic cellsVisceral activityCTBiodistributionChemotherapyDiffuse activityMolecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?
Savic LJ, Doemel LA, Schobert IT, Montgomery RR, Joshi N, Walsh JJ, Santana J, Pekurovsky V, Zhang X, Lin M, Adam L, Boustani A, Duncan J, Leng L, Bucala RJ, Goldberg SN, Hyder F, Coman D, Chapiro J. Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy? Radiology 2020, 296: 575-583. PMID: 32633675, PMCID: PMC7434651, DOI: 10.1148/radiol.2020200373.Peer-Reviewed Original ResearchConceptsImmuno-oncologic therapiesConventional transarterial chemoembolizationTransarterial chemoembolizationIntratumoral immune cell infiltrationMR spectroscopyRabbit liver tumor modelPrussian blue iron stainingAntigen-presenting immune cellsIntra-arterial infusionImmune cell infiltrationNew Zealand white rabbitsLiver tumor modelImmune cell exclusionLiver cancer modelContrast material administrationT2-weighted MRIZealand white rabbitsT2-weighted imagingResistance mechanismsImmunosuppressive tumorHLA-DRCell infiltrationImmune cellsImmunohistochemistry stainingRing enhancement
2018
Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis
Pucar D, Boustani AM, Bronen RA, Saperstein L. Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis. Clinical Nuclear Medicine 2018, 43: 284-286. PMID: 29401149, DOI: 10.1097/rlu.0000000000001981.Peer-Reviewed Educational MaterialsConceptsSinus diseasePituitary swellingSevere headacheVisual disturbancesLaboratory findingsMetastatic melanomaPituitary abnormalitiesRetrospective analysisContrast CTNoncontrast CTPituitary hormonesHypophysitisHeadacheDiseaseDiagnosisCTLow levelsNivolumabHypermetabolismImmunotherapyPETMelanomaAbnormalitiesFindingsHormoneMolecular imaging of prostate cancer
Boustani AM, Pucar D, Saperstein L. Molecular imaging of prostate cancer. British Journal Of Radiology 2018, 91: 20170736. PMID: 29243485, PMCID: PMC5966010, DOI: 10.1259/bjr.20170736.Peer-Reviewed Original ResearchConceptsProstate cancerNational Comprehensive Cancer Network guidelinesMetastatic diseaseMolecular imagingCommon malignancyNetwork guidelinesEffective treatmentMolecular imaging techniquesCancerMetabolic intermediaryTreatmentImaging techniquesRelevant radiotracersImagingTimely detectionAccurate imagingChemotherapySurgeryRecurrenceMalignancyDiseaseReceptors