2004
Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells
Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S. Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells. Blood 2004, 104: 166-169. PMID: 15026310, DOI: 10.1182/blood-2003-09-3293.Peer-Reviewed Original ResearchConceptsVascular progenitor cellsAll-trans retinoic acidChicken chorioallantoic membraneEndothelial cellsTie2 signalingProgenitor cellsBlood vessel formationMural cellsEpithelial layerExpression of angiopoietin-2Vessel formationRetinoic acidImpaired vascular remodelingImpaired branchingAngiopoietin-2Ang-1Vascular remodelingRo41-5253Cell interactionsMural cell interactions
2001
Development of the avian lymphatic system
Wilting J, Papoutsi M, Othman‐Hassan K, Rodriguez‐Niedenführ M, Pröls F, Tomarev S, Eichmann A. Development of the avian lymphatic system. Microscopy Research And Technique 2001, 55: 81-91. PMID: 11596153, DOI: 10.1002/jemt.1159.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBirdsChick EmbryoEndothelial Growth FactorsEndothelium, LymphaticHomeodomain ProteinsImmunohistochemistryIn Situ HybridizationLymphatic SystemQuailReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorTumor Suppressor ProteinsVascular Endothelial Growth Factor CHemangioblast Commitment in the Avian Allantois: Cellular and Molecular Aspects
Caprioli A, Minko K, Drevon C, Eichmann A, Dieterlen-Lièvre F, Jaffredo T. Hemangioblast Commitment in the Avian Allantois: Cellular and Molecular Aspects. Developmental Biology 2001, 238: 64-78. PMID: 11783994, DOI: 10.1006/dbio.2001.0362.Peer-Reviewed Original ResearchMeSH KeywordsAllantoisAnimalsCell LineageChick EmbryoCoturnixDNA-Binding ProteinsEndodermErythroid-Specific DNA-Binding FactorsGATA2 Transcription FactorGATA3 Transcription FactorHematopoietic Stem CellsImmunohistochemistryIn Situ HybridizationLeukocyte Common AntigensMesodermModels, BiologicalProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorRNA, MessengerTime FactorsTrans-ActivatorsTranscription FactorsConceptsGATA-2Allantoic budCommitment of mesodermTranscription factor GATA-2SCL/talHemopoietic cellsHemangioblast commitmentEndoderm specificationOrgan formationGATA-1Definitive lineageStage HH17Blood islandsBlood island-like structuresEndodermMolecular processesMesodermEngrafted hostsMolecular aspectsHemopoietic lineagesGene patternsYolk sacBudsQuail embryosEmbryosEndogenous origin of the lymphatics in the avian chorioallantoic membrane
Papoutsi M, Tomarev S, Eichmann A, Pröls F, Christ B, Wilting J. Endogenous origin of the lymphatics in the avian chorioallantoic membrane. Developmental Dynamics 2001, 222: 238-251. PMID: 11668601, DOI: 10.1002/dvdy.1187.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationChick EmbryoChickensChimeraChorionEndothelial Growth FactorsEndothelium, LymphaticGene Expression Regulation, DevelopmentalHomeodomain ProteinsMesodermQuailReceptor Protein-Tyrosine KinasesReceptors, Growth FactorTumor Suppressor ProteinsVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3ConceptsVascular endothelial growth factor receptor 3Allantoic budSplanchnic mesodermAllantoic mesodermHematopoietic cellsMesenchymal cellsQuail embryosChorioallantoic membraneEndothelial cellsGrowth factor receptor 3Intraembryonic sitesBlood islandsMesodermAllantoic epitheliumEmbryosEndothelial networksBudsAvian chorioallantoic membraneDay 4 embryosImportant functionsMRNA probesLymphangiogenic potentialLymphatic endotheliumCAM developmentChick embryosPlasticity of endothelial cells during arterial-venous differentiation in the avian embryo.
Moyon D, Pardanaud L, Yuan L, Bréant C, Eichmann A. Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo. Development 2001, 128: 3359-70. PMID: 11546752, DOI: 10.1242/dev.128.17.3359.Peer-Reviewed Original ResearchConceptsArterial-venous differentiationEndothelial plasticityEndothelial cellsEmbryonic day 7Jugular veinDay 7Vessel wallPrimary vascular systemNeuropilin-1Quail-chick chimerasHost arteryVenous fateEmbryonic developmentTransmembrane receptorsVenous markersEmbryonic day 2Venous endothelial cellsAortic endothelial cellsAvian embryosVascular developmentMost arteriesCarotid arteryVessel identityDay 11 embryosDorsal aortaSelective expression of angiopoietin 1 and 2 in mesenchymal cells surrounding veins and arteries of the avian embryo
Moyon D, Pardanaud L, Yuan L, Bréant C, Eichmann A. Selective expression of angiopoietin 1 and 2 in mesenchymal cells surrounding veins and arteries of the avian embryo. Cells And Development 2001, 106: 133-136. PMID: 11472842, DOI: 10.1016/s0925-4773(01)00425-7.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-1Angiopoietin-2AnimalsAortaArteriesChick EmbryoDown-RegulationEndothelium, VascularGene Expression Regulation, DevelopmentalHeartIn Situ HybridizationLymphatic SystemMembrane GlycoproteinsMesodermNeoplasm ProteinsProteinsProto-Oncogene ProteinsQuailReceptor, TIE-2RNA, MessengerVeins
2000
Hemangioblastic Precursors in the Avian Embryo
Eichmann A, Corbel C, Pardanaud L, Bréant C, Moyon D, Yuan L. Hemangioblastic Precursors in the Avian Embryo. Current Topics In Microbiology And Immunology 2000, 251: 83-90. PMID: 11036762, DOI: 10.1007/978-3-642-57276-0_11.Peer-Reviewed Original ResearchConceptsBlood islandsHemangioblastic precursorsHemopoietic cellsVascular endothelial growth factor receptor 2Embryonic yolk sacBlood island formationEndothelial cellsMesodermal cellsEndothelial growth factor receptor 2Avian embryosCell typesExtraembryonic areasYolk sacCommon precursorChick blastodermExternal cellsCellsInternal cellsRecent evidenceGrowth factor receptor 2Factor receptor 2Receptor 2HemangioblastsIslandsBlastoderm
1998
Segregation of the embryonic vascular and hemopoietic systems
Eichmann A, Corbel C, Le Douarin N. Segregation of the embryonic vascular and hemopoietic systems. Biochemistry And Cell Biology 1998, 76: 939-946. PMID: 10392707, DOI: 10.1139/o98-106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationChick EmbryoEmbryo, NonmammalianEndothelial Growth FactorsEndothelium, VascularHematopoietic Stem CellsLymphokinesMesodermMiceModels, CardiovascularQuailReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsEndothelial precursor cellsAvian embryosPrecursor cellsVEGF receptor VEGFR2Primary vascular systemEndothelial cellsGastrulation stageGrowth factorDevelopmental biologyVertebrate classesSpecific growth factorsVascular endothelial growth factorAngiogenic vascular endothelial growth factorMouse embryosMolecular mechanismsCognate receptorsSubsequent assemblyHemopoietic cellsEmbryosReceptor VEGFR2Hemopoietic systemCulture experimentsVEGFR2CellsSignificant insightsIntraaortic hemopoietic cells are derived from endothelial cells during ontogeny
Jaffredo T, Gautier R, Eichmann A, Dieterlen-Lièvre F. Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny. Development 1998, 125: 4575-4583. PMID: 9778515, DOI: 10.1242/dev.125.22.4575.Peer-Reviewed Original Research
1997
Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2
Eichmann A, Corbel C, Nataf V, Vaigot P, Bréant C, Le Douarin N. Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 5141-5146. PMID: 9144204, PMCID: PMC24645, DOI: 10.1073/pnas.94.10.5141.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCell DifferentiationChick EmbryoEndothelial Growth FactorsEndothelium, VascularGastrulaHematopoietic Stem CellsHomozygoteLigandsLymphokinesMesodermMiceMice, Inbred BALB CMice, KnockoutQuailReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factor receptor 2VEGFR2 ligandsEndothelial growth factor receptor 2Embryonic mesodermal cellsVascular endothelial lineageHemopoietic cellsDevelopmental decisionsGastrulation stageHomozygous null miceMesodermal cellsAbsence of VEGFGene productsGene targetingNull mutationEndothelial lineageHemopoietic differentiationExtracellular domainClonal culturesLineagesHemopoietic lineagesEndothelial differentiationEndothelial cell coloniesCell coloniesCell microenvironmentGrowth factor receptor 2
1996
Endothelin-B receptor is expressed by neural crest cells in the avian embryo.
Nataf V, Lecoin L, Eichmann A, Le Douarin N. Endothelin-B receptor is expressed by neural crest cells in the avian embryo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 9645-9650. PMID: 8790384, PMCID: PMC38482, DOI: 10.1073/pnas.93.18.9645.Peer-Reviewed Original ResearchConceptsNC cellsNC derivativesAvian embryosEnteric nervous system precursorsSpatiotemporal expression patternsNeural crest cellsEnteric nervous systemEndothelin B receptorGrowth-promoting pathwaysEndothelin-3NC developmentPluripotent stageNervous systemCrest cellsQuail homologueGene inactivationExpression patternsNeural crestNeural primordiumNeural tubeDevelopmental stagesEDNRB transcriptsEDNRB geneEmbryonic areaSmall populationVEGF121Induces Proliferation of Vascular Endothelial Cells and Expression offlk-1without Affecting Lymphatic Vessels of the Chorioallantoic Membrane
Wilting J, Birkenhäger R, Eichmann A, Kurz H, Martiny-Baron G, Marmé D, McCarthy J, Christ B, Weich H. VEGF121Induces Proliferation of Vascular Endothelial Cells and Expression offlk-1without Affecting Lymphatic Vessels of the Chorioallantoic Membrane. Developmental Biology 1996, 176: 76-85. PMID: 8654896, DOI: 10.1006/dbio.1996.9993.Peer-Reviewed Original ResearchAllantoisAnimalsCell DivisionChick EmbryoChorionCoturnixEndothelial Growth FactorsEndothelium, VascularGene Expression Regulation, DevelopmentalIn Situ HybridizationLymphatic SystemLymphokinesMicroscopy, ElectronMitogensNeovascularization, PhysiologicProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factors
1995
The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels
Couly G, Coltey P, Eichmann A, Le Douarin N. The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels. Cells And Development 1995, 53: 97-112. PMID: 8555115, DOI: 10.1016/0925-4773(95)00428-9.Peer-Reviewed Original ResearchConceptsCephalic paraxial mesodermParaxial mesodermCephalic mesodermAnterior paraxial mesodermBlood vessel endothelial cellsQuail-chick chimera techniqueVessel endothelial cellsEarly avian embryoEndothelial cellsOrigin of brainGastrulation stageMesodermal territoryMesodermal cellsQuail speciesAngiogenic potentialMesodermNeural crestNeural primordiumMolecular markersAvian embryosAvian homologueHigh growth rateStage-matched embryosHemopoietic cellsFlk-1
1994
Distinct developmental expression of a new avian fibroblast growth factor receptor
Marcelle C, Eichmann A, Halevy O, Bréant C, Le Douarin N. Distinct developmental expression of a new avian fibroblast growth factor receptor. Development 1994, 120: 683-694. PMID: 8162862, DOI: 10.1242/dev.120.3.683.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernChick EmbryoCloning, MolecularCoturnixFibroblast Growth Factor 2GastrulaGene ExpressionIn Situ HybridizationMolecular Sequence DataMusclesPolymerase Chain ReactionReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 4Receptors, Fibroblast Growth FactorConceptsFibroblast growth factor receptorGrowth factor receptorMesoderm-derived structuresSkeletal muscle lineageFibroblast growth factor receptor (FGFR) familySatellite cellsStage-specific mannerDistinct developmental expressionFactor receptorNew memberIg-like domainsEarly myotomeGrowth factor receptor familyPattern of expressionSkeletal muscleEmbryonic RNAPrimitive streak stageLateral epiblastMuscle lineageDays of developmentFactor receptor familyPrimary transcriptEarly avian developmentAvian developmentFibroblast growth factor
1993
Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development
Eichmann A, Marcelle C, Bréant C, Le Douarin N. Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development. Cells And Development 1993, 42: 33-48. PMID: 8396413, DOI: 10.1016/0925-4773(93)90096-g.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceChick EmbryoCloning, MolecularEmbryo, NonmammalianEndothelium, VascularMolecular Sequence DataProtein-Tyrosine KinasesQuailReceptor Protein-Tyrosine KinasesReceptors, MitogenReceptors, NeurotransmitterReceptors, Vascular Endothelial Growth FactorSequence Homology, Nucleic AcidVascular Endothelial Growth Factor Receptor-2ConceptsExpression patternsOnset of gastrulationAvian embryonic developmentEndothelial cellsEarly endothelial cellsMonoclonal antibody QH1Human genesEmbryonic developmentEmbryonic day 9Vascular endothelial growth factorHigh homologyHematopoietic lineagesAvian embryosPartial cloningSitu hybridizationReceptor moleculesGastrulationPutative precursorEndothelial cell mitogen vascular endothelial growth factorFlk-1GenesEmbryosGrowth factorQH1VEGF receptors
1992
Molecular cloning of a family of protein kinase genes expressed in the avian embryo.
Marcelle C, Eichmann A. Molecular cloning of a family of protein kinase genes expressed in the avian embryo. Oncogene 1992, 7: 2479-87. PMID: 1281306.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBlastocystChick EmbryoChickensCloning, MolecularEmbryo, NonmammalianGene ExpressionMolecular Sequence DataMultigene FamilyNervous SystemNeural CrestOligodeoxyribonucleotidesOrgan SpecificityPhylogenyPoly APolymerase Chain ReactionProtein KinasesProtein-Tyrosine KinasesQuailReceptors, Cell SurfaceRNARNA, MessengerSequence Homology, Amino AcidSequence Homology, Nucleic AcidTranscription, GeneticConceptsReceptor tyrosine kinasesPKS genesGrowth factor receptorPutative receptor tyrosine kinaseTyrosine kinaseSerine/threonine kinaseProtein kinase sequencesEarly vertebrate developmentProtein kinase geneCytosolic tyrosine kinasesFactor receptorFibroblast growth factor receptorGrowth factor receptor tyrosine kinasePlatelet-derived growth factor receptor alphaGrowth factor receptor alphaNorthern blot analysisPattern of expressionReceptor-like moleculesVertebrate developmentInsulin-like growth factor type I receptorKinase sequencesType I receptorThreonine kinaseMore transcriptsAvian homolog