Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development
Li J, Geraldo LH, Dubrac A, Zarkada G, Eichmann A. Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development. Journal Of The American Society Of Nephrology 2021, 32: 2255-2272. PMID: 34341180, PMCID: PMC8729857, DOI: 10.1681/asn.2020111640.Peer-Reviewed Original ResearchConceptsGlomerular vascularizationRobo receptorsKidney functionVascular developmentGlomerular perfusionKidney diseaseGlomerular endotheliumLigand trapInhibited vascularizationSlit2-RoboEndothelial proliferationGlomerular capillariesEndothelial compartmentGlomerular angiogenesisPerfusion analysisKidney vasculatureVascularizationUreteric bud branchingNovel roleAxon guidanceNephron developmentBlood filtrationReceptorsAngiogenesisGene deletion