2023
Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption
Zarkada G, Chen X, Zhou X, Lange M, Zeng L, Lv W, Zhang X, Li Y, Zhou W, Liu K, Chen D, Ricard N, Liao J, Kim Y, Benedito R, Claesson-Welsh L, Alitalo K, Simons M, Ju R, Li X, Eichmann A, Zhang F. Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption. Circulation Research 2023, 133: 333-349. PMID: 37462027, PMCID: PMC10530007, DOI: 10.1161/circresaha.123.322607.Peer-Reviewed Original ResearchConceptsLymphatic endothelial cellsCell-cell junctionsCytoskeleton contractionMolecular biology approachesSmall GTPase Rac1Cytoskeletal contractilityBiology approachGTPase Rac1Stress fibersA SignalingPI3KLipid uptakePermeability regulationLymphatic permeabilityIntestinal lipid absorptionLEC junctionJunction openingEndothelial cellsLymphatic capillariesVEGFR-2Fundamental mechanismsLymphatic barrierLymphatic vesselsVascular endothelial growthLymphatic junctions
2001
A model for gene therapy of human hereditary lymphedema
Karkkainen M, Saaristo A, Jussila L, Karila K, Lawrence E, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen M, Ylä-Herttuala S, Finegold D, Ferrell R, Alitalo K. A model for gene therapy of human hereditary lymphedema. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12677-12682. PMID: 11592985, PMCID: PMC60113, DOI: 10.1073/pnas.221449198.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAmino Acid SequenceAnimalsDependovirusDisease Models, AnimalEndothelial Growth FactorsGenetic TherapyHumansLymphedemaMaleMiceMice, Inbred BALB CMice, Inbred C3HMolecular Sequence DataNerve Tissue ProteinsNeuropilin-1Receptor Protein-Tyrosine KinasesReceptors, Growth FactorVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3