2024
Compartmentalized ocular lymphatic system mediates eye–brain immunity
Yin X, Zhang S, Lee J, Dong H, Mourgkos G, Terwilliger G, Kraus A, Geraldo L, Poulet M, Fischer S, Zhou T, Mohammed F, Zhou J, Wang Y, Malloy S, Rohner N, Sharma L, Salinas I, Eichmann A, Thomas J, Saltzman W, Huttner A, Zeiss C, Ring A, Iwasaki A, Song E. Compartmentalized ocular lymphatic system mediates eye–brain immunity. Nature 2024, 628: 204-211. PMID: 38418880, PMCID: PMC10990932, DOI: 10.1038/s41586-024-07130-8.Peer-Reviewed Original ResearchResponse to herpes simplex virusCentral nervous systemImmune response to herpes simplex virusPosterior eyeImmune responseTherapeutic immune responsesOptic nerve sheathCervical lymph nodesAdeno-associated virusCNS diseaseDeep cervical lymph nodesHerpes simplex virusImmune protected miceCentral nervous system tissueLymphatic drainage systemImmunological featuresAnatomical extensionNerve sheathOptic nerveGene therapyLymph nodesMultiple dosesSimplex virusLymphatic circuitLymphatic signal
2001
A model for gene therapy of human hereditary lymphedema
Karkkainen M, Saaristo A, Jussila L, Karila K, Lawrence E, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen M, Ylä-Herttuala S, Finegold D, Ferrell R, Alitalo K. A model for gene therapy of human hereditary lymphedema. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12677-12682. PMID: 11592985, PMCID: PMC60113, DOI: 10.1073/pnas.221449198.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAmino Acid SequenceAnimalsDependovirusDisease Models, AnimalEndothelial Growth FactorsGenetic TherapyHumansLymphedemaMaleMiceMice, Inbred BALB CMice, Inbred C3HMolecular Sequence DataNerve Tissue ProteinsNeuropilin-1Receptor Protein-Tyrosine KinasesReceptors, Growth FactorVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3