Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes
Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M. Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes. PLOS Genetics 2008, 4: e1000133. PMID: 18654640, PMCID: PMC2478640, DOI: 10.1371/journal.pgen.1000133.Peer-Reviewed Original ResearchMeSH KeywordsCCAAT-Binding FactorCell Line, TumorGene Expression RegulationGenome, HumanHepatocytesHumansModels, GeneticPromoter Regions, GeneticProtein BindingSp1 Transcription FactorSterol Regulatory Element Binding Protein 1Transcriptional ActivationConceptsTarget genesGenome-wide occupancyDNA-binding motifComplex transcriptional responseGenome tiling arraysDiverse biological pathwaysSREBP1 target genesCritical transcriptional regulatorNovel functional roleGene expression microarraysDistinct functional pathwaysCombinatorial regulationTarget promotersTranscriptional regulatorsTiling arraysRegulatory circuitryTranscriptional responseChromatin immunoprecipitationFatty acid metabolismExpression microarraysFunctional pathwaysBiological pathwaysHepatocyte cell lineHuman hepatocyte cell lineSp1