2009
Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells
Anderson SM, Khalil A, Uduman M, Hershberg U, Louzoun Y, Haberman AM, Kleinstein SH, Shlomchik MJ. Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells. The Journal Of Immunology 2009, 183: 7314-7325. PMID: 19917681, PMCID: PMC4106706, DOI: 10.4049/jimmunol.0902452.Peer-Reviewed Original ResearchConceptsLow-affinity B cellsLow-affinity cellsGerminal centersB cellsHigh-affinity B cellsHigh-affinity cellsDeath rateHigh death rateLower death ratesImmune responseHigh-affinity AbsB lymphocytesMemory responsesExtracellular pathogensSame AgPrimary responseGC reactionProliferative advantageSimilar ratesSurvivalCellsCell cycleControl of survivalHigh affinityResponse
2003
Rheumatoid Factors in Health and Disease: Structure, Function, Induction and Regulation
Haberman AM, William J, Euler C, Shlomchik MJ. Rheumatoid Factors in Health and Disease: Structure, Function, Induction and Regulation. Current Directions In Autoimmunity 2003, 6: 169-195. PMID: 12408052, DOI: 10.1159/000066861.Peer-Reviewed Original ResearchAnimalsAntibodies, Anti-IdiotypicAntigens, T-IndependentApoptosisAutoimmune DiseasesB-Lymphocyte SubsetsDisease Models, AnimalFas ReceptorHumansImmune ToleranceImmunizationImmunoglobulin Constant RegionsImmunoglobulin GLupus Erythematosus, SystemicMiceMice, Inbred MRL lprMice, TransgenicReference ValuesRheumatoid FactorT-Lymphocyte Subsets