2023
Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA
Rosenstock J, Frias J, Jastreboff A, Du Y, Lou J, Gurbuz S, Thomas M, Hartman M, Haupt A, Milicevic Z, Coskun T. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. The Lancet 2023, 402: 529-544. PMID: 37385280, DOI: 10.1016/s0140-6736(23)01053-x.Peer-Reviewed Original ResearchConceptsGlucose-dependent insulinotropic polypeptideType 2 diabetesGLP-1 receptor agonistsEscalation groupPhase 2 trialReceptor agonistDulaglutide groupPlacebo groupStudy treatmentGLP-1Interactive web response systemModerate gastrointestinal adverse eventsType 2 diabetes managementCurrent consensus guidelinesGastrointestinal adverse eventsWeb response systemPhase 1 studyStudy site personnelHealth care centersGlucagon receptor agonistPhase 3 programRange of dosesPhase 2 dataBaseline HbAGlycaemic targets
2021
COVID‐19 vaccines are effective in people with obesity: A position statement from The Obesity Society
Butsch WS, Hajduk A, Cardel MI, Donahoo WT, Kyle TK, Stanford FC, Zeltser LM, Kotz CM, Jastreboff AM. COVID‐19 vaccines are effective in people with obesity: A position statement from The Obesity Society. Obesity 2021, 29: 1575-1579. PMID: 34212511, PMCID: PMC8441899, DOI: 10.1002/oby.23251.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccineObesity SocietyCOVID-19-associated hospitalizationPosition statementEfficacy of vaccinesSARS-CoV-2Pfizer-BioNTechAvailable vaccinesUS FoodDrug AdministrationObesityVaccineEmergency useHigh efficacyPeer-reviewed literatureScientific evidenceCOVID-19EfficacyTime of publicationBriefing documentsDefinitive wayHospitalizationPatientsVaccinationAdministration
2017
Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight
Chao AM, Jastreboff AM, White MA, Grilo CM, Sinha R. Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight. Obesity 2017, 25: 713-720. PMID: 28349668, PMCID: PMC5373497, DOI: 10.1002/oby.21790.Peer-Reviewed Original ResearchConceptsFuture weight gainAppetite-related hormonesFood cravingsChronic stressWeight gainProspective community cohortFood Craving InventoryTotal ghrelinCommunity cohortBlood drawMorning cortisolClinical covariatesHormone levelsBody weightCortisol responseHigher food cravingsHigher cortisolCortisolCumulative Adversity InterviewCravingLinear mixed modelsBaselineGhrelinHormoneMonths
2016
Disordered Eating Behaviors in Emerging Adults With Type 1 Diabetes: A Common Problem for Both Men and Women
Doyle EA, Quinn SM, Ambrosino JM, Weyman K, Tamborlane WV, Jastreboff AM. Disordered Eating Behaviors in Emerging Adults With Type 1 Diabetes: A Common Problem for Both Men and Women. Journal Of Pediatric Health Care 2016, 31: 327-333. PMID: 27843015, DOI: 10.1016/j.pedhc.2016.10.004.Peer-Reviewed Original ResearchConceptsDEPS-R scoreBody mass index valuesHemoglobin A1c levelsPoor glycemic controlDiabetes Eating Problem SurveyType 1 diabetesEating Problem SurveyMass index valuesPrevalence of DEBOverweight patientsSevere complicationsA1c levelsGlycemic controlEA womenEA menType 1Further evaluationProblem SurveyEating behaviorsWomenMenT1D.T1DScoresAdultsElevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO
Gaiser EC, Gallezot JD, Worhunsky PD, Jastreboff AM, Pittman B, Kantrovitz L, Angarita GA, Cosgrove KP, Potenza MN, Malison RT, Carson RE, Matuskey D. Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO. Neuropsychopharmacology 2016, 41: 3042-3050. PMID: 27374277, PMCID: PMC5101552, DOI: 10.1038/npp.2016.115.Peer-Reviewed Original ResearchConceptsBody mass indexVentral striatumObese individualsD2/3R availabilityOB individualsReward regionsSubstantia nigra/ventral tegmental areaDopamine D2/3 receptor availabilityNormal-weight individualsTreatment of obesityVentral tegmental areaNovel pharmacologic targetsD2/3 receptor availabilitySN/VTAAgonist tracersOverweight cohortMass indexWeight individualsTegmental areaBrain reward regionsAntagonist tracersPharmacologic targetReceptor availabilitySecondary analysisNW individualsUtility of Psychological Screening of Young Adults with Type 1 Diabetes Transitioning to Adult Providers
Quinn SM, Ambrosino JM, Doyle EA, Weyman K, Tamborlane WV, Jastreboff AM. Utility of Psychological Screening of Young Adults with Type 1 Diabetes Transitioning to Adult Providers. Endocrine Practice 2016, 22: 1104-1110. PMID: 27295017, DOI: 10.4158/ep151190.or.Peer-Reviewed Original ResearchConceptsChart reviewEating Problem SurveyDiabetes distressAdditional patientsYoung adultsDepressive symptomsProblem SurveyPoor glycemic controlDiabetes Eating Problem SurveyBody mass indexDiabetes Distress ScalePatient Health QuestionnaireType 1 diabetesTransition clinicGlycemic controlMass indexPHQ-8Formal screeningAdult providersGlycated hemoglobinSymptomatic depressionAdult careHealth QuestionnaireMetabolic controlPatients
2014
Blunted striatal responses to favorite-food cues in smokers
Jastreboff AM, Sinha R, Lacadie CM, Balodis IM, Sherwin R, Potenza MN. Blunted striatal responses to favorite-food cues in smokers. Drug And Alcohol Dependence 2014, 146: 103-106. PMID: 25444233, PMCID: PMC4272899, DOI: 10.1016/j.drugalcdep.2014.09.006.Peer-Reviewed Original ResearchConceptsFavorite-food cuesNeural responsesNeutral-relaxing conditionsBody mass indexCue exposureBrain mechanismsRewarding stimuliBrain responsesStriatal responsesCuesDiminished activationLower body mass indexLean body massSmoking cessationMass indexSmoking statusFMRIInsulaSmokersWeight gainStimuliRatingsAudiotapesCaudateBody massSex differences in the association between dietary restraint, insulin resistance and obesity
Jastreboff AM, Gaiser EC, Gu P, Sinha R. Sex differences in the association between dietary restraint, insulin resistance and obesity. Eating Behaviors 2014, 15: 286-290. PMID: 24854820, PMCID: PMC4032476, DOI: 10.1016/j.eatbeh.2014.03.008.Peer-Reviewed Original ResearchConceptsBody mass indexInsulin resistanceMass indexRestrained eatingHomeostatic model assessmentSex differencesObese weight categoriesEating Behavior QuestionnaireEventual weight gainDutch Eating Behavior QuestionnaireHOMA-IRPlasma insulinObservational studyModel assessmentAbstractTextWeight categoriesWeight gainDietary restraintLarge community sampleFood consumptionWomenMenAIMSCommunity sampleBehavior Questionnaire
2013
Comparison of BMI and Physical Activity Between Old Order Amish Children and Non-Amish Children
Hairston KG, Ducharme JL, Treuth MS, Hsueh WC, Jastreboff AM, Ryan KA, Shi X, Mitchell BD, Shuldiner AR, Snitker S. Comparison of BMI and Physical Activity Between Old Order Amish Children and Non-Amish Children. Diabetes Care 2013, 36: 873-878. PMID: 23093661, PMCID: PMC3609522, DOI: 10.2337/dc12-0934.Peer-Reviewed Original ResearchConceptsMin/dayPhysical activityOld Order AmishNutrition Examination Survey dataBMI z-scoreVigorous physical activityComparison of BMIHip-worn accelerometersOld Order Amish childrenNon-Hispanic white populationPediatric overweightMean BMIExcess weightNational HealthLong-term protectionLow prevalenceES groupNHANES estimatesChildhood factorsZ-scorePA levelsBMIDiabetesAnthropometric dataWhite population