2018
Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity
GROSKREUTZ D, SINHA R, LACADIE C, LAM W, HAMZA M, SCHMIDT C, SEO D, HWANG J, BELFORT-DEAGUIAR R, LEVENTHAL J, ROSENBERG S, PARIKH L, CONSTABLE T, SHERWIN R, JASTREBOFF A. Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity. Diabetes 2018, 67 DOI: 10.2337/db18-365-or.Peer-Reviewed Original ResearchCerebral blood flowElevated insulin levelsInsulin levelsFunctional magnetic resonance imagingLean humansObese humansHour oral glucose tolerance testOral glucose tolerance testSetting of hyperinsulinemiaGlucose tolerance testEuglycemic hyperinsulinemic clampEffect of hyperinsulinemiaAnterior cingulate cortexMagnetic resonance imagingWhole-brain analysisFood-seeking behaviorMiddle temporal gyrusMannKind CorporationCBF responseCNS effectsSatiety factorTolerance testBrain perfusionOB groupLN group
2016
American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines Formedical Care of Patients with Obesity
Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R, Guidelines R. American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines Formedical Care of Patients with Obesity. Endocrine Practice 2016, 22: 1-203. PMID: 27219496, DOI: 10.4158/ep161365.gl.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClinical practice guidelinesAmerican CollegeAdiposity-based chronic diseaseDetailed evidence-based recommendationsReal-world medical careCoronary Artery Risk DevelopmentOral glucose tolerance testClinical Endocrinologists ACEWeight-related complicationsGlucose tolerance testPrevention of diabetesIndividualization of careSelection of therapyBehavioral modificationEvidence-based recommendationsMedical care planAmerican AssociationQuality of lifeHigh-quality careAACE protocolAdjustable gastricSibutramine TrialRecommendation gradesNonpharmacologic interventionsClinical Endocrinologists