2022
Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networks
2018
Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity
GROSKREUTZ D, SINHA R, LACADIE C, LAM W, HAMZA M, SCHMIDT C, SEO D, HWANG J, BELFORT-DEAGUIAR R, LEVENTHAL J, ROSENBERG S, PARIKH L, CONSTABLE T, SHERWIN R, JASTREBOFF A. Hyperinsulinemia Invokes Greater Brain Perfusion in Reward and Motivation Regions in Obesity. Diabetes 2018, 67 DOI: 10.2337/db18-365-or.Peer-Reviewed Original ResearchCerebral blood flowElevated insulin levelsInsulin levelsFunctional magnetic resonance imagingLean humansObese humansHour oral glucose tolerance testOral glucose tolerance testSetting of hyperinsulinemiaGlucose tolerance testEuglycemic hyperinsulinemic clampEffect of hyperinsulinemiaAnterior cingulate cortexMagnetic resonance imagingWhole-brain analysisFood-seeking behaviorMiddle temporal gyrusMannKind CorporationCBF responseCNS effectsSatiety factorTolerance testBrain perfusionOB groupLN group