1999
Role of Phosphorylation of Alzheimer’s Amyloid Precursor Protein during Neuronal Differentiation
Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn A, Kirino Y, Greengard P, Suzuki T. Role of Phosphorylation of Alzheimer’s Amyloid Precursor Protein during Neuronal Differentiation. Journal Of Neuroscience 1999, 19: 4421-4427. PMID: 10341243, PMCID: PMC6782598, DOI: 10.1523/jneurosci.19-11-04421.1999.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCell DifferentiationMutationNerve Tissue ProteinsNeuronsPC12 CellsPhosphorylationRatsThreoninePhosphorylation of the Cytoplasmic Domain of Alzheimer's β-Amyloid Precursor Protein at Ser655 by a Novel Protein Kinase
Isohara T, Horiuchi A, Watanabe T, Ando K, Czernik A, Uno I, Greengard P, Nairn A, Suzuki T. Phosphorylation of the Cytoplasmic Domain of Alzheimer's β-Amyloid Precursor Protein at Ser655 by a Novel Protein Kinase. Biochemical And Biophysical Research Communications 1999, 258: 300-305. PMID: 10329382, DOI: 10.1006/bbrc.1999.0637.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsBrainChromatography, Ion ExchangeCytoplasmPhosphorylationProtein Serine-Threonine KinasesRatsSerineConceptsNovel protein kinaseAlzheimer's beta-amyloid precursor proteinProtein kinase CExtracellular signal-regulated kinaseProtein kinaseCytoplasmic domainCalmodulin-dependent protein kinase IIΒ-amyloid precursor proteinPrecursor proteinAlzheimer's β-Amyloid Precursor ProteinSignal-regulated kinaseProtein kinase IIBeta-amyloid precursor proteinKinase IUnidentified proteinsKinase IIKinase CKinaseSer655ProteinAlzheimer's diseaseThr654Rat brainPhosphorylationDomain
1998
Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade
Desdouits‐Magnen J, Desdouits F, Takeda S, Syu L, Saltiel A, Buxbaum J, Czernik A, Nairn A, Greengard P. Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade. Journal Of Neurochemistry 1998, 70: 524-530. PMID: 9453546, DOI: 10.1046/j.1471-4159.1998.70020524.x.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsCalcium-Calmodulin-Dependent Protein KinasesCarbacholCHO CellsCOS CellsCricetinaeEnzyme ActivationEnzyme InhibitorsFlavonoidsHumansIndolesMaleimidesMitogen-Activated Protein Kinase KinasesMuscarinic AgonistsNerve Growth FactorsPC12 CellsPhorbol 12,13-DibutyrateProtein Kinase InhibitorsProtein KinasesRatsReceptor, Muscarinic M1Receptors, MuscarinicConceptsProtein kinase CAlzheimer amyloid precursor proteinKinase cascadeM1 muscarinic receptor stimulationMitogen-Activated Protein Kinase CascadeProtein kinase cascadeMAP kinase cascadeMAP kinase kinaseMAP kinase-independent pathwayMitogen-activated protein kinase kinase activationDominant negative mutantPrecursor proteinDistinct secretory pathwaysPKC-independent pathwayStimulation of PKCAmyloid precursor proteinKinase-independent pathwaySAPP secretionKinase kinaseSecretory pathwayNegative mutantMAP kinaseKinase activationRegulation of secretionPD 98059
1997
Phosphorylation of Alzheimer β-Amyloid Precursor-like Proteins †
Suzuki T, Ando K, Isohara T, Oishi M, Lim G, Satoh Y, Wasco W, Tanzi R, Nairn A, Greengard P, Gandy S, Kirino Y. Phosphorylation of Alzheimer β-Amyloid Precursor-like Proteins †. Biochemistry 1997, 36: 4643-4649. PMID: 9109675, DOI: 10.1021/bi962618k.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCytoplasmGliomaHeLa CellsHumansNerve Tissue ProteinsPhosphorylationProtein Structure, TertiaryRatsTumor Cells, CulturedConceptsAlzheimer's beta-amyloid precursor proteinCytoplasmic domain peptidePrecursor-like proteinsProtein kinase CCytoplasmic domainCultured cellsCell cycle-dependent mannerKinase CDomain peptideCycle-dependent mannerAmino acid sequenceHomologous amino acid sequencesGene familyKinase siteAcid sequenceExtracellular domainIntact cellsAPLP2Proteolytic processingAPLP1PhosphorylationPrecursor proteinProteinBeta-amyloid precursor proteinCdc2The Cytoplasmic Domain of Alzheimer’s Amyloid Precursor Protein Is Phosphorylated at Thr654, Ser655, and Thr668 in Adult Rat Brain and Cultured Cells
Oishi M, Nairn A, Czernik A, Lim G, Isohara T, Gandy S, Greengard P, Suzuki T. The Cytoplasmic Domain of Alzheimer’s Amyloid Precursor Protein Is Phosphorylated at Thr654, Ser655, and Thr668 in Adult Rat Brain and Cultured Cells. Molecular Medicine 1997, 3: 111-123. PMID: 9085254, PMCID: PMC2230054, DOI: 10.1007/bf03401803.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmino Acid SequenceAmyloid beta-Protein PrecursorAnimalsAntibodiesBrainCells, CulturedCytoplasmHeLa CellsHumansMolecular Sequence DataPC12 CellsPhosphorylationRatsSerineThreonineConceptsAlzheimer's disease amyloid precursor proteinCytoplasmic domainCultured cell linesCell cycle-dependent mannerAmyloid precursor proteinCultured cellsCycle-dependent mannerPhosphorylation state-specific antibodiesPhosphorylation-specific antibodiesPrecursor proteinCell linesProtein kinase C.Stoichiometric phosphorylationG2/M phaseAPP isoformsThr654Alzheimer amyloid precursor proteinOkadaic acidBiological functionsCell cycleKinase C.Intact cellsPhosphorylationHeLa cellsSpecific inhibitor
1993
Protein Phosphorylation Regulates Relative Utilization of Processing Pathways for Alzheimer β/A4 Amyloid Precursor Proteina
GANDY S, CAPORASO G, BUXBAUM J, DA CRUZ E SILVA O, IVERFELDT K, NORDSTEDT C, SUZUKI T, CZERNIK A, NAIRN A, GREENGARD P. Protein Phosphorylation Regulates Relative Utilization of Processing Pathways for Alzheimer β/A4 Amyloid Precursor Proteina. Annals Of The New York Academy Of Sciences 1993, 695: 117-121. PMID: 8239268, DOI: 10.1111/j.1749-6632.1993.tb23038.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAmyloid beta-Protein PrecursorAnimalsHumansPC12 CellsPhosphoproteinsPhosphorylationProtein Processing, Post-TranslationalSerineConceptsOkadaic acid-sensitive proteinAlzheimer amyloid precursor proteinAcid-sensitive proteinProtein kinase CProtein phosphorylationKinase CCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIProtein kinase IISignal transductionPhosphorylation stateModulation of betaKinase IISecretory cleavageSubstrate redistributionPrecursor proteinCurrent experimental evidenceAmyloid precursor proteinProteinCleavage pathwayPhosphorylationProcessing pathwaysSubstrate activationSer655APP metabolism
1992
Characterization of Alternative Routes for Processing of the Alzheimer β/A4‐Amyloid Precursor Protein
GANDY S, CAPORASO G, RAMABHADRAN T, SUZUKI T, BUXBAUM J, NORDSTEDT C, IVERFELDT K, CZERNIK A, NAIRN A, GREENGARD P. Characterization of Alternative Routes for Processing of the Alzheimer β/A4‐Amyloid Precursor Protein. Annals Of The New York Academy Of Sciences 1992, 674: 203-217. PMID: 1363189, DOI: 10.1111/j.1749-6632.1992.tb27489.x.Peer-Reviewed Original ResearchThe nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer βA4-amyloid precursor protein: Some technical notes
Gandy S, Buxbaum J, Suzuki T, Ramabhadran T, Caporaso G, Nairn A, Greengard P. The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer βA4-amyloid precursor protein: Some technical notes. Neurobiology Of Aging 1992, 13: 601-603. PMID: 1461349, DOI: 10.1016/0197-4580(92)90063-4.Peer-Reviewed Original Research