1994
Subcellular localization of CFTR to endosomes in a ductal epithelium
Webster P, Vanacore L, Nairn A, Marino C. Subcellular localization of CFTR to endosomes in a ductal epithelium. American Journal Of Physiology 1994, 267: c340-c348. PMID: 7521124, DOI: 10.1152/ajpcell.1994.267.2.c340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEndocytosisEpitheliumFluorescent Antibody TechniqueImmunohistochemistryMaleMembrane ProteinsMicroscopy, FluorescenceOrganellesRatsRats, Sprague-DawleyReceptors, Cell SurfaceSubcellular FractionsSubmandibular GlandTissue DistributionConceptsCystic fibrosis transmembrane conductance regulatorPlasma membraneFibrosis transmembrane conductance regulatorApical plasma membraneAnti-CFTR antibodiesNormal epithelial cell populationsTransmembrane conductance regulatorCytochemical evidenceReceptor-mediated endocytosisCFTR moleculesEpithelial cell populationsCellular processesSubcellular compartmentsSubcellular localizationEarly endosomesMembrane recyclingConductance regulatorSubcellular distributionSubapical vesiclesApical poleEndosomesCFTR functionImmunoelectron microscopyCell populationsCFTR immunoreactivity
1989
Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons
Conn P, Strong J, Azhderian E, Nairn A, Greengard P, Kaczmarek L. Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons. Journal Of Neuroscience 1989, 9: 473-479. PMID: 2537389, PMCID: PMC6569795, DOI: 10.1523/jneurosci.09-02-00473.1989.Peer-Reviewed Original ResearchConceptsProtein kinase CBag cell neuronsVoltage-dependent calcium currentsCAMP-PKPhorbol esterKinase CCell neuronsAction potentialsCalcium currentInhibitor of PKCProtein kinase inhibitorsPhorbol ester-induced enhancementKinase inhibitor 1Protein kinase inhibitor 1Adenylate cyclase activator forskolinCyclase activator forskolinProtein inhibitorGranule movementVoltage-dependent currentsCell action potentialsCAMP analogEffect of forskolinActivator forskolinPhorbol ester-induced changesNeuronal excitability