1994
Specificity of protein kinase inhibitor peptides and induction of long-term potentiation.
Hvalby O, Hemmings H, Paulsen O, Czernik A, Nairn A, Godfraind J, Jensen V, Raastad M, Storm J, Andersen P. Specificity of protein kinase inhibitor peptides and induction of long-term potentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 4761-4765. PMID: 8197132, PMCID: PMC43868, DOI: 10.1073/pnas.91.11.4761.Peer-Reviewed Original ResearchConceptsProtein kinase CProtein kinase inhibitor peptideProtein kinase inhibitionInhibitor peptideDependent protein kinase IIInhibition of PKCKinase inhibitionProtein kinase IIPseudosubstrate domainAutoregulatory domainProtein kinasePhysiological assaysKinase IIKinase CLong-term potentiationSynthetic peptide analoguesInductionPeptide analoguesHippocampal neuronsPeptidesIntracellular deliveryBlockade of inductionInduction of LTPInhibitionVitro
1991
Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons
Greengard P, Jen J, Nairn A, Stevens C. Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons. Science 1991, 253: 1135-1138. PMID: 1716001, DOI: 10.1126/science.1716001.Peer-Reviewed Original ResearchConceptsProtein kinaseCAMP-dependent protein kinaseGlutamate receptor channelsMonophosphate-dependent protein kinaseReceptor channelsType glutamate receptor channelsAdenylate cyclase cascadeCultured hippocampal pyramidal neuronsSpontaneous excitatory postsynaptic currentsWhole-cell current responsesSingle-channel analysisNeuromodulatory regulationMammalian brainExcitatory postsynaptic currentsHippocampal pyramidal neuronsKinaseLong-term potentiationPyramidal neuronsPostsynaptic currentsGlutamate responseExcitatory neurotransmitterMean open timeHippocampal neuronsAdenylate cyclaseSynaptic events