2011
Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease
Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: e128-e135. PMID: 21555590, PMCID: PMC3102344, DOI: 10.1073/pnas.1101964108.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseIschemic cerebral small-vessel diseaseCerebral small vessel diseaseGranular osmiophilic materialMouse modelCerebral autosomal dominant arteriopathySmooth muscle cell degenerationBrain vessel pathologyPrevalent human conditionVascular smooth muscle cellsNotch 3 mutationPostmortem human tissueAutosomal dominant arteriopathyTransgenic mouse modelIschemic stroke susceptibilityAge-dependent phenotypeMuscle cell degenerationSmooth muscle cellsNotch-3 receptorCommon monogenic causeIschemic strokeVascular dementiaSubcortical infarctsReceptor activity assaysHuman brain vessels
2008
Linking Notch signaling to ischemic stroke
Arboleda-Velasquez JF, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz SI, Liao JK, Salomone S, Ayata C, Moskowitz MA, Artavanis-Tsakonas S. Linking Notch signaling to ischemic stroke. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 4856-4861. PMID: 18347334, PMCID: PMC2290794, DOI: 10.1073/pnas.0709867105.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsGenetic rescue experimentsUnderlying cellular pathwaysSpecific gene targetsKnockout mouse modelCellular pathwaysIschemic strokeGene targetsRescue experimentsSMC functionLong-term neurological disabilityMolecular analysisPathophysiology of strokeIschemic phenotypeMuscle cellsNotch-3Neurological disabilityCommon causeMouse modelStriking susceptibilityParaloguesStrokeNotchPhenotype