Featured Publications
Motivations of women in Uganda living with rheumatic heart disease: A mixed methods study of experiences in stigma, childbearing, anticoagulation, and contraception
Chang A, Nabbaale J, Nalubwama H, Okello E, Ssinabulya I, Longenecker C, Webel A. Motivations of women in Uganda living with rheumatic heart disease: A mixed methods study of experiences in stigma, childbearing, anticoagulation, and contraception. PLOS ONE 2018, 13: e0194030. PMID: 29590159, PMCID: PMC5874006, DOI: 10.1371/journal.pone.0194030.Peer-Reviewed Original ResearchConceptsWomen of childbearing ageRheumatic heart diseaseFocus groupsLack of health system resourcesLimited health literacyQualitative descriptive methodologyHealth system resourcesHeart diseaseMixed methods studyMiddle-income countriesMale partnersChildbearing ageHealth literacyPatient empowermentWomen of reproductive ageAbandonment of patientsHealth programsPremature mortalitySide effects of contraceptivesDescriptive methodologyConsiderable stigmaIncreased risk of cardiovascular complicationsQualitative studyRisk of cardiovascular complicationsLMICs
2024
Interviewer biases in medical survey data: The example of blood pressure measurements
Geldsetzer P, Chang A, Meijer E, Sudharsanan N, Charu V, Kramlinger P, Haarburger R. Interviewer biases in medical survey data: The example of blood pressure measurements. PNAS Nexus 2024, 3: pgae109. PMID: 38525305, PMCID: PMC10959064, DOI: 10.1093/pnasnexus/pgae109.Peer-Reviewed Original ResearchBlood pressure measurementsHealth SurveyGlobal health indicatorsMiddle-income countriesInterviewer effectsHypertension prevalenceBlood pressureHealth agenciesLinear mixed modelsHealth indicatorsPhysical measurementsPrevalence estimatesSystolic blood pressurePressure measurementsGlobal SouthHealthInterviewsSubdistrict levelIndividual factorsSurvey dataMedical survey dataInterview techniquesMixed modelsRandom effectsProportion of variation
2023
Healthcare provider-targeted mobile applications to diagnose, screen, or monitor communicable diseases of public health importance in low- and middle-income countries: A systematic review
Geldsetzer P, Flores S, Flores B, Rogers A, Chang A. Healthcare provider-targeted mobile applications to diagnose, screen, or monitor communicable diseases of public health importance in low- and middle-income countries: A systematic review. PLOS Digital Health 2023, 2: e0000156. PMID: 37801442, PMCID: PMC10558072, DOI: 10.1371/journal.pdig.0000156.Peer-Reviewed Original ResearchMiddle-income countriesCommunicable diseasesMHealth technologiesRandomized clinical trialsCochrane Central for studiesTargeting health professionalsSelf-management toolsPaper-based toolsPatient self-management toolsCountry of developmentDiseases of public health importanceSystematically searched PubMedWeb of ScienceHealth professionalsPublic health importanceMethod of screeningSample sizeTablet-basedInclusion criteriaLMICsPriority diseasesExtract dataClinical calculatorsHealth importanceCommunication facilitatorEffectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial
Chang A, Rahman M, Talukder A, Shah H, Mridha M, Hasan M, Sarker M, Geldsetzer P. Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial. Trials 2023, 24: 480. PMID: 37501102, PMCID: PMC10375753, DOI: 10.1186/s13063-023-07518-3.Peer-Reviewed Original ResearchConceptsLow-sodium salt substituteCommunity health workersCluster randomized controlled trialHealth workersRural BangladeshImplementing health interventionsBackgroundHigh blood pressureMonths post-interventionBlood pressureExcessive salt consumptionMiddle-income countriesRandomized controlled trialsBlood pressure improvementPublic health problemHigh blood pressureLow-sodium saltPost-interventionCommunity healthHealth interventionsMortality reductionSalt consumptionHealth consequencesHealth problemsBlood pressure-lowering interventionsControlled trialsWhat We Lost in the Fire: Endemic Tropical Heart Diseases in the Time of COVID-19.
Chang A, Zühlke L, Ribeiro A, Barry M, Okello E, Longenecker C. What We Lost in the Fire: Endemic Tropical Heart Diseases in the Time of COVID-19. American Journal Of Tropical Medicine And Hygiene 2023, 108: 462-464. PMID: 36746666, PMCID: PMC9978545, DOI: 10.4269/ajtmh.22-0514.Peer-Reviewed Original ResearchConceptsHeart diseaseMiddle-income countriesGlobal health equityCOVID-19 pandemicHealth equityHealth disparitiesHealthcare providersCare systemMalaria control initiativesRheumatic heart diseaseGroup of disordersControl statusCOVID-19Time of COVID-19Control initiativesFunding increasesEndomyocardial fibrosisSubstantial mortalityDiseaseEndemic illnessOutcomesChagas diseasePeopleCareHealthcare
2022
A systematic review of healthcare provider-targeted mobile applications for non-communicable diseases in low- and middle-income countries
Geldsetzer P, Flores S, Wang G, Flores B, Rogers A, Bunker A, Chang A, Tisdale R. A systematic review of healthcare provider-targeted mobile applications for non-communicable diseases in low- and middle-income countries. Npj Digital Medicine 2022, 5: 99. PMID: 35853936, PMCID: PMC9296618, DOI: 10.1038/s41746-022-00644-3.Peer-Reviewed Original ResearchNoncommunicable diseasesMiddle-income countriesCochrane Central for studiesEpidemic of noncommunicable diseasesSystematic reviewTargeting health professionalsDisability-adjusted life yearsNon-communicable diseasesCountry of developmentLow-resource settingsHigh-income countriesApple iOS operating systemsMHealth innovationsWeb of ScienceDatabases of PubMedHealth professionalsMHealth technologiesHealthcare providersMobile healthPublic health importanceMHealth applicationsLMICsTablet-basedLife yearsInclusion criteriaRecent Advances in the Rheumatic Fever and Rheumatic Heart Disease Continuum
Rwebembera J, Nascimento B, Minja N, de Loizaga S, Aliku T, dos Santos L, Galdino B, Corte L, Silva V, Chang A, Dutra W, Nunes M, Beaton A. Recent Advances in the Rheumatic Fever and Rheumatic Heart Disease Continuum. Pathogens 2022, 11: 179. PMID: 35215123, PMCID: PMC8878614, DOI: 10.3390/pathogens11020179.Peer-Reviewed Original ResearchRheumatic heart diseaseHuman immunodeficiency virusRheumatic feverLatent rheumatic heart diseaseManagement of rheumatic heart diseaseGroup A <i>Streptococcus</i>Burden of rheumatic heart diseaseSecondary antibiotic prophylaxisAntibiotic prophylaxisGAS pharyngitisEchocardiographic screeningImmunodeficiency virusDiagnostic strategiesHeart diseaseTertiary managementVaccine developmentMiddle-income countriesNarrative reviewDisease continuumRF/RHDDiseaseFeverGlobal eradicationInfectious diseasesRheumatism
2021
Abstract 11913: Mortality Along the Rheumatic Heart Disease Cascade of Care in Uganda
Chang A, Barry M, Bendavid E, Watkins D, Beaton A, Lwabi P, Ssinabulya I, Longenecker C, Okello E. Abstract 11913: Mortality Along the Rheumatic Heart Disease Cascade of Care in Uganda. Circulation 2021, 144: a11913-a11913. DOI: 10.1161/circ.144.suppl_1.11913.Peer-Reviewed Original ResearchClinical rheumatic heart diseaseRheumatic heart diseasePublic health response to HIVMortality riskCare of HIV patientsMiddle-income countriesMortality of peopleCox proportional hazards modelsCare modelRetrospective cohort studyClinical careParticipant dataResponse to HIVCareAssess mortalityCohort studyHazard ratioAdherent subjectsEpidemiological evidenceSub-Saharan AfricaHeart failure historyKaplan-Meier curvesReference groupHazards modelMortality benefitClinical Outcomes, Echocardiographic Findings, and Care Quality Metrics for People Living With Human Immunodeficiency Virus (HIV) and Rheumatic Heart Disease in Uganda
Chang A, Rwebembera J, Bendavid E, Okello E, Barry M, Beaton A, Haeffele C, Webel A, Kityo C, Longenecker C. Clinical Outcomes, Echocardiographic Findings, and Care Quality Metrics for People Living With Human Immunodeficiency Virus (HIV) and Rheumatic Heart Disease in Uganda. Clinical Infectious Diseases 2021, 74: 1543-1548. PMID: 34382644, DOI: 10.1093/cid/ciab681.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusRheumatic heart diseaseEchocardiographic findingsImmunodeficiency virusHeart diseaseClinical outcomesDiagnosis of human immunodeficiency virusPrescription ratesAge- and sex-matched cohortMedication prescription ratesLongitudinal outcomes of patientsCare quality metricsOutcomes of patientsMiddle-income countriesEpidemiology of patientsSex-matched cohortAll-cause mortalityStroke/transient ischemic attackRate of strokeMedian ageClinical careCardiovascular complicationsClinical characteristicsMultivariable adjustmentConcurrent diagnosis