Featured Publications
Outcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda
Chang A, Nabbaale J, Okello E, Ssinabulya I, Barry M, Beaton A, Webel A, Longenecker C. Outcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda. Journal Of The American Heart Association 2020, 9: e015562. PMID: 32295465, PMCID: PMC7428530, DOI: 10.1161/jaha.119.015562.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAnticoagulantsComorbidityFemaleHealthcare DisparitiesHumansMaleMedication AdherenceOutcome and Process Assessment, Health CareQuality Indicators, Health CareRegistriesReproductive HealthRetention in CareRetrospective StudiesRheumatic Heart DiseaseRisk AssessmentRisk FactorsSex FactorsTime FactorsTreatment OutcomeUgandaWomen's HealthYoung AdultConceptsRheumatic heart diseaseWomen of reproductive ageHeart diseaseReproductive ageClinical rheumatic heart diseaseRheumatic Heart Disease RegistryAdherence to guideline-based therapyNew York Heart Association class III-IV heart failurePrescription of warfarinRisk of cardiovascular complicationsCox proportional hazards modelsProportional hazards modelRetrospective cohort studyGuideline-based therapyAdherence ratesDisease RegistryCohort studyAnticoagulant prescriptionSub-Saharan AfricaAnticoagulant useCardiovascular complicationsClinical outcomesCompare comorbiditiesHazards modelHeart failure
2021
N‐Terminal Pro‐B‐Type Natriuretic Peptide as a Biomarker for the Severity and Outcomes With COVID‐19 in a Nationwide Hospitalized Cohort
O’Donnell C, Ashland M, Vasti E, Lu Y, Chang A, Wang P, Daniels L, de Lemos J, Morrow D, Rodriguez F, O’Brien C. N‐Terminal Pro‐B‐Type Natriuretic Peptide as a Biomarker for the Severity and Outcomes With COVID‐19 in a Nationwide Hospitalized Cohort. Journal Of The American Heart Association 2021, 10: e022913. PMID: 34889112, PMCID: PMC9075235, DOI: 10.1161/jaha.121.022913.Peer-Reviewed Original ResearchConceptsElevated NT-proBNPCardiovascular risk factorsNT-proBNPHospital mortalityHeart failureRisk factorsCOVID-19N-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideElevated NT-proBNP concentrationsElevated NT-proBNP levelsIntensive care unit admissionLog-transformed NT-proBNPMajor adverse cardiac eventsMore cardiovascular risk factorsPrior heart failureAdverse cardiac eventsCare unit admissionNT-proBNP levelsNT-proBNP concentrationsObservational cohort studyShorter median timeRisk of deathUnit admissionCardiac events
2016
Regenerative Medicine: Potential Mechanisms of Cardiac Recovery in Takotsubo Cardiomyopathy
Chang A, Kittle J, Wu S. Regenerative Medicine: Potential Mechanisms of Cardiac Recovery in Takotsubo Cardiomyopathy. Current Treatment Options In Cardiovascular Medicine 2016, 18: 20. PMID: 26874708, PMCID: PMC4957545, DOI: 10.1007/s11936-016-0443-0.Peer-Reviewed Original ResearchCardiac recoveryPathophysiology of Takotsubo syndromeAcute chest painAssociated with significant hemodynamic compromiseAcute heart failureSignificant hemodynamic compromiseResponse to injurySystolic dysfunctionChest painTakotsubo syndromeHemodynamic compromiseHeart failureDisease courseInciting insultHistological studiesTakotsuboPotential mechanismsDiseaseCardiomyopathyPainPathophysiologySyndromeCytoprotective processDysfunctionSystolic