2016
CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
Böhm UL, Prendergast A, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C. CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nature Communications 2016, 7: 10866. PMID: 26946992, PMCID: PMC4786674, DOI: 10.1038/ncomms10866.Peer-Reviewed Original ResearchConceptsSpinal cordSpinal circuitsCentral pattern generatorCSF-cNsCerebrospinal fluid-contacting neuronsSpinal central pattern generatorVentral spinal cordLocomotor central pattern generatorCSF-contacting neuronsCentral canalSpinal bendingCordNeuronsMechanical stimuliMechanosensory organsOrgansSensory modalitiesAnimals
2012
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development
Prendergast A, Linbo TH, Swarts T, Ungos JM, McGraw HF, Krispin S, Weinstein BM, Raible DW. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development 2012, 139: 1141-1152. PMID: 22296847, PMCID: PMC3283124, DOI: 10.1242/dev.072439.Peer-Reviewed Original ResearchConceptsRECK functionsNeural crestForward genetic screenCell fate specificationMultipotent cell lineagesCell-autonomous fashionCysteine-rich proteinNeural crest cellsSensory neuron formationReversion-inducing cysteine-rich proteinGenetic screenInhibitors of metalloproteinasesFate specificationSensory neuron precursorsCell motilityCrest cellsCell lineagesProper migrationDRG formationDRG developmentNeuron formationMyriad tissuesKazal motifsNeuron precursorsGenes